Limited extent and consequences of pancreatic SARS-CoV-2 infection

Heide, Verena van der; Jangra, Sonia; Cohen, Phillip; Rathnasinghe, Raveen; Aslam, Sadaf; Aydillo, Teresa; Geanon, Daniel; Handler, Diana; Kelley, Geoffrey; Lee, Brian; Rahman, Adeeb; Dawson, Travis; Qi, Jingjing; D’souza, Darwin; Kim‐Schulze, Seunghee; Panzer, Julia K.; Caicedo, Alejandro; Kusmartseva, Irina; Posgai, Amanda L.; Atkinson, Mark A.; Albrecht, Randy A.; García‐Sastre, Adolfo; Rosenberg, Brad R.; Schotsaert, Michael; Homann, Dirk

doi:10.1016/j.celrep.2022.110508

Cited by 48 publications

(58 citation statements)

References 108 publications

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“… 48 Studies in adults are generally more concordant and show evidence of increased risk of diabetes in people with COVID-19. 49 , 50 , 51 Our study sheds light on this and provides evidence of increased risk in adults among both non-hospitalised and hospitalised individuals at 1 year after COVID-19 diagnosis; and that most (>99%) of diagnoses of diabetes in our cohort relate to type 2 diabetes.…”

Section: Discussionsupporting

confidence: 54%

Risks and burdens of incident diabetes in long COVID: a cohort study

Xie

Al‐Aly

2022

The Lancet Diabetes & Endocrinology

418

363

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Section: Discussionsupporting

confidence: 54%

Risks and burdens of incident diabetes in long COVID: a cohort study

Xie

Al‐Aly

2022

The Lancet Diabetes & Endocrinology

418

363

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“… Wu C.-T. et al (2021) showed that 3–5% of α-cells from primary islets incubated with SARS-CoV-2 also expressed viral N-protein and/or S-protein. Further, in the study by van der Heide et al (2022) , 2.6% of GCG (+)/N-protein (+) cells were detected by flow cytometry in the samples from seven donors. Simultaneously, detailed proteomic mass cytometry analysis showed infection in 1% of α-cells and 1.8% of α-like cells, which show phenotypic similarity to α-cells but with lower GCG expression ( van der Heide et al, 2022 ).…”

Section: Are Pancreatic Cells Infected By Sars-cov-2?mentioning

confidence: 80%

“…In human primary islets infected ex vivo with SARS-CoV-2, Yang et al (2020) identified the expression of S-protein in β-cells. 11.6% of INS(+)/N-protein (+) cells were found within infected human primary islets as assayed by flow cytometry ( van der Heide et al, 2022 ). Of note, detailed mass cytometry analysis showed that N-protein and/or S-protein are coexpressed by 4% of β-cells and up to 48% of β-like cells, which are defined by high and lower INS expression, respectively (van der Heide).…”

Section: Are Pancreatic Cells Infected By Sars-cov-2?mentioning

confidence: 99%

Diabetes and SARS-CoV-2–Is There a Mutual Connection?

Jedrzejak

Urbaniak

Waśko

et al. 2022

Front. Cell Dev. Biol.

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SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple organs in humans, including the pancreas. Here, we present the bilateral link between the pathophysiology of diabetes and COVID-19, with diabetes being COVID-19 comorbidity, and a complication of SARS-CoV-2 infection. Analysis of clinical data indicates that patients with chronic conditions like diabetes are at increased risk of severe COVID-19, hospitalization, ICU admission, and death compared to the healthy subjects. Further, we show that SARS-CoV-2 infection might be also associated with the development of new-onset diabetes and diabetic ketoacidosis. We then discuss the options for studying SARS-CoV-2 infection in pancreatic settings, including the use of human pluripotent stem cell-derived pancreatic organoids. Further, we review the presence of SARS-CoV-2 receptors in different pancreatic cell types and the infection efficiency based on pancreatic sections from COVID-19 patients and primary human islet in vitro studies. Finally, we discuss the impact of SARS-CoV-2 infection on human pancreatic cell homeostasis, focusing on β-cells.

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“…Lack of significantly higher anti-SARS-CoV-2 antibodies in children with incident T1DM during pandemic have argued against the temporal association between COVID-19 and T1DM [19] , [20] . Moreover, recent reports indicate that infection of human pancreatic islets by COVID-19 remains largely non-cytopathic and unlikely to precipitate new-onset diabetes [21] . Nonetheless, insulin resistance and disordered insulin release consequent to up-regulated cytokines during post-acute COVID-19 phase may indeed contribute to excess risk of incident T2DM in these subjects [22] , [23] .…”

Section: Discussionmentioning

confidence: 99%