2017
DOI: 10.1093/mmy/myx074
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Limonene inhibits Candida albicans growth by inducing apoptosis

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Cited by 47 publications
(41 citation statements)
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“…Previous studies described that the use of this monoterpene in concentrations between 0.6 to 5 mM induces apoptosis in C. albicans , due to the damage caused to both the cell wall and membrane. In that study, the authors claimed that cell death was likely due to oxidative stress produced by limonene, which leads to DNA damage, alterations of the cell cycle, and, finally, yeast apoptosis [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies described that the use of this monoterpene in concentrations between 0.6 to 5 mM induces apoptosis in C. albicans , due to the damage caused to both the cell wall and membrane. In that study, the authors claimed that cell death was likely due to oxidative stress produced by limonene, which leads to DNA damage, alterations of the cell cycle, and, finally, yeast apoptosis [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Limonene damages the C. albicans cell wall/membrane, thereby modifying cellular adhesion and plasticity, pH, and ionic content [26]. In addition, such damage causes oxidative stress and consequent DNA damage, resulting in cell cycle modulation and apoptosis as demonstrated by Thakre et al [28]. The high concentration of limonene in the EO could contribute to its nematocidal effect [29].…”
Section: Discussionmentioning
confidence: 99%
“…The activity of this EO would be related to the large amount of limonene, sabinene and citronellal. These compounds strongly inhibit C. albicans [22,23,24]. However, S. cerevisiae showed a reduced sensitivity versus other EOs provided of antifungal activity, such as L. cubeba and C. citratus.…”
Section: Discussionmentioning
confidence: 99%