Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities

Abstract

Abstract:A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1)

Nimbolide Inhibits Nuclear Factor-КB Pathway in Intestinal Epithelial Cells and Macrophages and Alleviates Experimental Colitis in Mice

“…It is usually found in plant families of Meliaceae and Rutaceae (Roy and Saraf, 2006;Tundis et al, 2014). Limonoid compounds have been shown to have various medical effects such as antiviral, antibacterial, antifungal, antimalarial, antiinflammatory, and anticancer (Chen et al, 2015;Dzoyem et al, 2015;Koul et al, 2004;Miller et al, 2004;Nakagawa et al, 2001).…”

Nitric Oxide Production‐Inhibitory Activity of Limonoids from Azadirachta indica and Melia azedarach

“…Several limonoids including those of azadirone‐, gedunin‐, mexicanolide‐, obacunone‐, and phragmalin‐types, and highly rearranged limonoids from Meliaceae plants, and highly rearranged and degraded limonoids from Lutaceae plants have so far been reported by other workers to exhibit inhibitory activity of NO production in mouse macrophage RAW 264.7 cells. Among these limonoids, an azadirone‐type limonoid: epoxyazadiratione; a gedunin‐type limonoid: 7‐deacetylgedunin ( 73 ); three mexicanolide‐type limonoids: trichinenlides B and C, and heytrijunolide D; five phragmalin‐type limonoids: chuktabrins D, H, I, and J, and chuktabularin U; and a highly rearranged limonoid, harperfolide, have been demonstrated to possess potent activity ( IC 50 < 10 μ m ) without any significant cytotoxicity.…”

Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities

“…Human neutrophils from the venous blood [ 21 ] of healthy, adult volunteers (20–35 years old) were isolated using a standard method of dextran sedimentation, prior to centrifugation in a Ficoll Hypaque gradient and hypotonic lysis of erythrocytes, as previously described [ 29 ]. Purified neutrophils containing >98% viable cells, as determined by the trypan blue exclusion method, were resuspended in HBSS buffer at pH 7.4 and were maintained at 4 °C, prior to use [ 30 ].…”

“…The percentage of superoxide inhibition of the test compound was calculated as the percentage of inhibition = {(control − resting) − (compound − resting)}/(control − resting) × 100. The software SigmaPlot was used for determining the IC 50 values [ 30 ].…”