Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K+ channels

Kang, Purum; Seol, Geun Hee

doi:10.1111/jphp.12359

Cited by 21 publications

(14 citation statements)

References 28 publications

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“…Given that the vascular endothelium controls vascular contractile force through secretion of contractile or relaxant factors such as NO [12], and secreted NO reduces vascular smooth muscle tension through the sGC-cyclic guanosine monophosphate (cGMP) pathway [13], these results suggest that the effects of neroli are mediated, at least in part, through its actions on the NO/ sGC pathway. This conclusion is supported by a previous study showing that an extract of linalool-one of the main components of neroli-elicited vasodilation of the rat aorta through effects on the NO/cGMP pathway [14].…”

Section: Discussionsupporting

confidence: 71%

Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation

Kang

Ryu

Lee

et al. 2016

Biomedicine & Pharmacotherapy

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Section: Discussionsupporting

confidence: 71%

Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation

Kang

Ryu

Lee

et al. 2016

Biomedicine & Pharmacotherapy

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“…Isolated LO reduced the hypercontraction of aortic segments induced by heavy metals, such as As and Hg, and involved the enhancement of NO synthesis and the blockade of voltage-dependent calcium channels [ 60 ]. Deep investigation of the mechanism of action of LO indicated further participation of soluble guanylyl cyclase and K + channel on its vasorelaxant effects [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular Activity of the Chemical Constituents of Essential Oils

et al. 2017

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Cardiovascular diseases are a leading cause of death in developed and developing countries and decrease the quality of life, which has enormous social and economic consequences for the population. Recent studies on essential oils have attracted attention and encouraged continued research of this group of natural products because of their effects on the cardiovascular system. The pharmacological data indicate a therapeutic potential for essential oils for use in the treatment of cardiovascular diseases. Therefore, this review reports the current studies of essential oils chemical constituents with cardiovascular activity, including a description of their mechanisms of action.

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“…Hence it is likely that OBE reduces IOP by inhibiting cholinesterase activity. Additionally, linalool is known to cause direct vasorelaxation [24,25]. Since trabecular meshwork cells are known to possess smooth muscle cells like properties [26], it is likely that OBE causes relaxation of trabecular meshwork resulting in enhanced aqueous humor drainage and consequently reduced IOP.…”

Section: Discussionmentioning

confidence: 99%

IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension

Agarwal¹,

Gupta

Srivastava

et al. 2019

JCHS

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Introduction: Ocimum basilicum (OB), a herb known for its antihypertensive, anticholinesterase and antioxidant properties was investigated for possible intraocular pressure (IOP) lowering effects in rabbits with ocular hypertension (OHT). Methods: The IOP lowering effect of a single drop of OB extract (OBE) was evaluated in oculonormotensive rabbits using three concentrations (0.25, 0.5 and 1% w/v). The concentration showing maximum IOP reduction was further evaluated in rabbits with water-loading and steroid-induced OHT. Results: IOP lowering effect of OBE 0.5% in oculonormotensive rabbit eyes was significantly greater compared to OBE 0.25% (p<0.05) but was comparable (p>0.05) to OBE 1%. Therefore, 0.5% concentration was selected for further evaluation. Pretreatment with OBE (0.5%) caused significantly lower increase in IOP after water loading amounting to 23.39% above baseline as compared to 54.00% in control eye, 15 minutes post water loading. At 60 minutes, post water loading, mean IOP rise was 95.12% and 63.58% in control and test eyes, respectively. Significant difference between the mean IOP of two eyes persisted during the 2nd hr. In rabbits with steroid induced OHT, OBE 0.5% produced a mean IOP reduction of 24.73% at the end of first hr and the mean peak IOP reduction of 31.63% was observed at the end of 2 hr. A significant difference between the IOP of test and control eyes persisted from 1 to 6 hr. Conclusions: Ocimum basilicum seed extract showed significant IOP lowering effect in rabbits with water loading and steroid induced OHT, however, its utility as an effective antiglaucoma medication needs further investigations.

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Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K+ channels

Abstract: Our findings indicate that LIN may induce endothelium-dependent vasorelaxation in mouse thoracic aortae by activating soluble guanylyl cyclase and K(+) channels.

Cited by 21 publications

References 28 publications

Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation

Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca2+ modulation

Cardiovascular Activity of the Chemical Constituents of Essential Oils

IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension

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