LINC-PINT Activates the Mitogen-Activated Protein Kinase Pathway to Promote Acute Myocardial Infarction by Regulating miR-208a-3p

Abstract

failure is highly generated. 4 Massive efforts are needed to improve the therapy of AMI.MicroRNAs (miRNAs) are a class of endogenic, non-coding single-stranded RNAs, approximately 21-25 nucleotides long. 5 MiRNAs participate in many biological processes such as cell growth, proliferation, apoptosis and differentiation, and many miRNAs have been reported to be indicated in various oncological and cardiovascular diseases. 6 Recent studies have shown that miR-1 and miR-208, which are the heart-specific or heart-enriched miRNAs, can be released into circulating blood after AMI. 7 The miR-208 family includes miR-208a, miR-208b and miR-499. MiR-208a is encoded by the intron of the

A lncRNA survey finds increases in neuroprotective LINC‐PINT in Parkinson’s disease substantia nigra

“…In healthy donors, large‐scale transcriptomic data from the GTEX database (Mele et al, ) revealed age‐related decreases in LINC‐PINT expression in several key brain regions, including the SN. Combined, these findings provided preliminary evidence for the involvement of this lncRNA, previously identified as involved in cancer (Garitano‐Trojaola et al, ), myocardial infarction (Zhu et al, ), and embryonic development (Sauvageau et al, ), and in neurodevelopment and neurodegeneration as well.…”

“…We further found a 1.8-fold increase in SNCA overexpressing compared to control MPNCs (Figure 3e) 2013,2017). Changes in LINC-PINT levels have been identified in cancer (Garitano-Trojaola et al, 2018), and it has been shown to play a role in myocardial infarction (Zhu et al, 2018) and in embryonic development (Sauvageau et al, 2013). However, to the best of our knowledge, our current study is the first indication for LINC-PINT function in neurodegeneration.…”

“…At the cellular level, LINC‐PINT expression is downregulated by inhibition of the cancer‐related protein P53 (Marin‐Bejar et al, ) and it interacts with the Polycomb Repressive Complex 2 (PRC2) (Marin‐Bejar et al, , ). Changes in LINC‐PINT levels have been identified in cancer (Garitano‐Trojaola et al, ), and it has been shown to play a role in myocardial infarction (Zhu et al, ) and in embryonic development (Sauvageau et al, ). However, to the best of our knowledge, our current study is the first indication for LINC‐PINT function in neurodegeneration.…”

“…LncRNAs participate in key cellular functions such as modification of transcriptional and translational processes by various molecular mechanisms, including scaffolding of RNA–protein structures, competition with endogenous mRNAs over microRNA (miRNA) binding (Kopp & Mendell, ), and epigenetic regulation (Marin‐Bejar et al, ). LncRNAs are involved both in normal physiological functions, such as embryonic development and muscle activity, and in pathological states such as cancer and cardiovascular disease (Huarte, ; Zhu et al, ). In the healthy central nervous system, lncRNAs play a role in neuronal function and differentiation (Fatica & Bozzoni, ; Tan et al, ).…”

LINC‐PINT alleviates lung cancer progression via sponging miR‐543 and inducing PTEN

“…For instance, LINC‐PINT can inhibit pancreatic ductal adenocarcinoma by activating TGF‐β signaling . LINC‐PINT can activate the MAPK signaling to induce acute myocardial infarction via sponging miR‐208a‐3p . However, whether LINC‐PINT affects the biological behavior of NSCLC cells through regulating miRNAs remains undetermined.…”