LINC00261 elevation inhibits angiogenesis and cell cycle progression of pancreatic cancer cells by upregulating SCP2 via targeting FOXP3

Abstract

Pancreatic cancer (PC) is one of the most aggressive and malignant tumours with a dismal five-year survival rate. [1][2][3] Indeed, over 80% of PC patients already have metastasis or locally advanced tumours at time of diagnosis, and less than 15%-20% of patients are suitable for surgical resection 4,5 . The poor prognosis of PC is largely attributable to its late diagnosis, [6][7][8] which implies that identification of specific diagnostic markers might improve the outcome.Long non-coding RNAs (lncRNAs) serve as key mediators in many cellular processes. 9 For example, decreased LINC00261 expression occurs in gastric cancer, whereas its over-expression could inhibit cell growth dynamics. 10,11 Moreover, Chen et al. 12 found that LINC00261 was also associated with PC cell migration.

LncRNA FOXP4-AS1 Promotes the Progression of Esophageal Squamous Cell Carcinoma by Interacting With MLL2/H3K4me3 to Upregulate FOXP4

“…Each member has a highly conserved structural domain of approximately 100 amino acids (35). Numerous studies have shown that forkhead proteins can act as transcription factors to regulate the transcription of target genes (36)(37)(38). FOXP4, a member of the P subfamily of the forkhead box (FOX) family, is a novel transcription factor (39).…”

Research Trends in C-Terminal Domain Nuclear Envelope Phosphatase 1

“…Therefore, CTDNEP1 suppresses brain tumors by triggering MYC amplification and genomic instability. There are several articles showing the possibility of using CTD phosphatases as tumor suppressors [ 5 , 7 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. CTDSP1 has also been reported as a phosphatase of MYC Ser62 in liver cancers [ 59 ].…”