LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages

Xing, Zeyu; Zhang, Menglu; Liu, Jiaqi; Liu, Gang; Feng, Kexin; Wang, Xiang

doi:10.1016/j.molimm.2021.07.009

Cited by 22 publications

(15 citation statements)

References 26 publications

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“…Our researches demonstrated that LOX expression has a negative correlation with the sensitivity of commonly used chemotherapeutic drugs for gastric cancer. M2 macrophage polarization induces tumor chemoresistance to paclitaxel and fluorouracil, which was well supported by many researches (Xing et al, 2021;Wei et al, 2019). Hence, we speculate that the overexpression of LOX may result in tumor chemoresistance of gastric cancer by promoting M2 macrophage polarization.…”

Section: Discussionsupporting

confidence: 71%

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Nai

Zeng

et al. 2022

Front. Cell Dev. Biol.

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Gastric carcinoma is the fourth most prevalent cause of cancer-related deaths worldwide because of dismal prognosis and few therapeutic options. Accumulated studies have indicated that targeting lysyl oxidase (LOX) family members may serve as an anticancer strategy. Nevertheless, the specific mechanisms of LOX in stomach carcinoma are still unclear. In this study, we demonstrated that LOX is significantly different in 13 types of cancers and may act as a potential therapeutic target, especially in stomach carcinoma. Moreover, overexpression of LOX in gastric carcinoma was validated by multiple databases and contributed to the poor overall survival (OS), progression-free survival (PFS) and post-progression survival (PPS) of stomach adenocarcinoma (STAD) patients. Next, based on the ceRNA hypothesis, the HIF1A-AS2/RP11-366L20.2-miR-29c axis was characterized as the upstream regulatory mechanism of LOX gene overexpression in gastric cancer by combining correlation analysis, expression analysis, and survival analysis. Finally, we illustrated that LOX gene overexpression leads to dismal prognosis of gastric cancer, perhaps through promoting M2 macrophage polarization and tumor immune escape and enhancing drug resistance of tumor cells to chemotherapeutic drugs. Our research demonstrate that LOX may be potentially applied as a novel prognostic marker and targeting inhibition of LOX holds promise as a treatment strategy for gastric cancer.

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Section: Discussionsupporting

confidence: 71%

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Nai

Zeng

et al. 2022

Front. Cell Dev. Biol.

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“…The lncRNA LINC00337 is upregulated in breast cancer cells and promotes paclitaxel resistance by affecting the TAM phenotype. LINC00337 promotes CCL2, IL-13, and M-CSF secretion inducing macrophage recruitment and M2 polarization, as demonstrated by the upregulation of the M2 markers CD163 and ARGM2 macrophages, which then increase the malignant behavior of chemo-resistant cancer cells by promoting their survival and migratory abilities [80]. Tables 1 and 2 recapitulate the role of ncRNAs in TAM-induced breast cancer chemoresistance.…”

Section: The Role Of Mirnas and Lncrnas In Tam-induced Chemoresistanc...mentioning

confidence: 86%

Non-Coding RNAs in the Crosstalk between Breast Cancer Cells and Tumor-Associated Macrophages

Benedetti

Turco

Fontemaggi

et al. 2022

ncRNA

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Non-coding RNAs (ncRNAs) play a pivotal role in regulating the tumor microenvironment (TME) by controlling gene expression at multiple levels. In tumors, ncRNAs can mediate the crosstalk between cancer cells and other cells in the TME, such as immune cells, stromal cells, and endothelial cells, influencing tumor development and progression. Tumor-associated macrophages (TAMs) are among the most abundant inflammatory cells infiltrating solid cancers that promote tumorigenesis, and their infiltration correlates with a poor prognosis in many tumors. Cancer cells produce different ncRNAs that orchestrate TAM recruitment and polarization toward a tumor-promoting phenotype. Tumor-reprogrammed macrophages shape the TME by promoting angiogenesis and tissue remodeling, and suppressing the anti-tumor activity of adaptive immune cells. TAMs can also produce ncRNA molecules that boost cancer cell proliferation and direct their phenotype and metabolic changes facilitating cancer progression and metastasis. This review will focus on the crosstalk between cancer cells and TAMs mediated by microRNAs and long non-coding RNAs during breast cancer (BC) initiation and progression.

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“… 37 Moreover, M2 tumour-associated macrophages can increase the activity of tumour cells and mediate the EMT process in tumours. 38 TGFB1 is an important immune marker of Tregs, and expression of DLEU2 correlates positively with TGFB1. Bao et al showed that TGFB1 induces immune escape in LIHC by increasing the expression of PD-1 and CTLA-4 on T cells.…”

Section: Discussionmentioning

confidence: 97%

Prognostic Value of Long Noncoding RNA DLEU2 and Its Relationship with Immune Infiltration in Kidney Renal Clear Cell Carcinoma and Liver Hepatocellular Carcinoma

Fu¹,

Gong²,

Wang³

et al. 2021

IJGM

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LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages

Cited by 22 publications

References 26 publications

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

lncRNA/miR-29c-Mediated High Expression of LOX Can Influence the Immune Status and Chemosensitivity and Can Forecast the Poor Prognosis of Gastric Cancer

Non-Coding RNAs in the Crosstalk between Breast Cancer Cells and Tumor-Associated Macrophages

Prognostic Value of Long Noncoding RNA DLEU2 and Its Relationship with Immune Infiltration in Kidney Renal Clear Cell Carcinoma and Liver Hepatocellular Carcinoma

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