LINC01426 contributes to clear cell renal cell carcinoma progression by modulating CTBP1/miR‐423‐5p/FOXM1 axis via interacting with IGF2BP1

Jiang, Yufeng; Zhang, HaiMin; Li, Wei; Yang, Yan; Yao, Xudong; Gu, Wei

doi:10.1002/jcp.29871

Cited by 23 publications

(24 citation statements)

References 43 publications

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“…The expression and function of LINC01426 in human cancers have recently attracted considerable interest. LINC01426 is upregulated in glioma, 25 clear cell renal cell carcinoma, 27 and lung adenocarcinoma, 28 and elevated LINC01426 expression is associated with adverse clinicopathological characteristics. 25,27,28 In addition, LINC01426 is reportedly an independent predictor of prognosis in glioma.…”

Section: Discussionmentioning

confidence: 99%

“…LINC01426 is upregulated in glioma, 25 clear cell renal cell carcinoma, 27 and lung adenocarcinoma, 28 and elevated LINC01426 expression is associated with adverse clinicopathological characteristics. 25,27,28 In addition, LINC01426 is reportedly an independent predictor of prognosis in glioma. 25 Functionally, LINC01426 exerts pro-oncogenic activities in glioma, 25,26 clear cell renal cell carcinoma, 27 and lung adenocarcinoma, 28 and it is implicated in the regulation of multiple tumor biological phenotypes.…”

Section: Discussionmentioning

confidence: 99%

“…25,27,28 In addition, LINC01426 is reportedly an independent predictor of prognosis in glioma. 25 Functionally, LINC01426 exerts pro-oncogenic activities in glioma, 25,26 clear cell renal cell carcinoma, 27 and lung adenocarcinoma, 28 and it is implicated in the regulation of multiple tumor biological phenotypes. Therefore, the effect of LINC01426 on the malignant phenotype of NSCLC warranted investigation.…”

Section: Discussionmentioning

confidence: 99%

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<p>Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression</p>

Dai

Wang

Zhao

et al. 2020

CMAR

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Purpose Recent studies have identified important roles for long intergenic non-protein coding RNA 1426 ( LINC01426 ) in glioma and clear cell renal cell carcinoma. The present study evaluated the expression profile of LINC01426 in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, the function of LINC01426 in NSCLC and the molecular mechanisms involved were extensively studied. Methods The abundance of LINC01426 in NSCLC tissues and cell lines was determined using quantitative reverse transcription–polymerase chain reaction. The cell counting kit-8 assay, flow cytometry, transwell experiments for migration and invasion, and xenograft tumor model were used to assess the function of LINC01426 in NSCLC cells. Mechanistic studies were performed using the luciferase reporter assay and RNA immunoprecipitation. Results Significant LINC01426 upregulation was observed in NSCLC tissues and cell lines. Silencing LINC01426 inhibited proliferation, migration, and invasion of NSCLC cells and facilitated cell apoptosis in vitro. Furthermore, interference of LINC01426 restricted tumor growth of NSCLC cells in vivo. In addition, LINC01426 showed the ability to directly bind to microRNA-519d-5p (miR-519d-5p) and act as a molecular sponge for miR-519d-5p in NSCLC cells. Furthermore, the ETS proto-oncogene 1 ( ETS1 ) was identified as a direct target of miR-519d-5p and LINC01426 could indirectly upregulate ETS1 expression by sponging miR-519d-5p. Moreover, the cancer-inhibiting activities of LINC01426 knockdown in NSCLC cells were partially offset by miR-519d-5p inhibition. Conclusion LINC01426 increases ETS1 expression by sequestering miR-519d-5p, thereby aggravating the malignant progression of NSCLC. The LINC01426/miR-519d-5p/ETS1 competing endogenous RNA pathway may provide a target for designing therapeutic agents for NSCLC treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression</p>

Dai

Wang

Zhao

et al. 2020

CMAR

View full text Add to dashboard Cite

show abstract

“…CTBP1 and HDAC2 can also inhibit miR-423-5p expression, while downregulated miR-423-5p can Targeted upregulation of FOXM1 expression to promote the progress of ccRCC. 88 In the above studies, it was found that the expression of miR-423 was often inhibited and played an anti-tumor role ( Figure 5).…”

Section: Mechanism Of Mir-423 and Lncrna In Human Tumormentioning

confidence: 91%

“…87 LINC01426 is upregulated in the renal clear cell carcinoma (ccRCC) cell line, promoting the proliferation and migration of rccRCC cells. 88 Mechanistically, LINC01426 upregulates FOXM1 expression by inhibiting miR-423-5p, while LINC01426 can recruit IGF2BP1 to increase CTBP1 expression. CTBP1 and HDAC2 can also inhibit miR-423-5p expression, while downregulated miR-423-5p can Targeted upregulation of FOXM1 expression to promote the progress of ccRCC.…”

Section: Mechanism Of Mir-423 and Lncrna In Human Tumormentioning

confidence: 99%