LIND'S TREATISE ON SCURVY. A Bicentenary Volume containing a reprint of the First Edition of “A Treatise of the Scurvy” by James Lind, M.D., with Additional Notes. Edited by C. P. Stewart and Douglas Guthrie. Edinburgh: University Press. 1953. Pp. 440. With a portrait, three plates, and a genealogy

Draper, M. H.

doi:10.1113/expphysiol.1953.sp001028

Cited by 2 publications

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“…It was not until 1928 when Albert Szent-Gyorgyi first isolated ascorbic acid and until 1932 when it was shown to be the antiscorbutic factor by Szent-Gyorgyi and King. 70 , 71 …”

Section: Ascorbic Acidmentioning

confidence: 99%

Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Bharat¹,

Manhas²,

Gutcho³

et al. 2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis.

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“…It was not until 1928 when Albert Szent-Gyorgyi first isolated ascorbic acid and until 1932 when it was shown to be the antiscorbutic factor by Szent-Gyorgyi and King. 70 , 71 …”

Section: Ascorbic Acidmentioning

confidence: 99%

Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Bharat¹,

Manhas²,

Gutcho³

et al. 2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

View full text Add to dashboard Cite

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“…Unable to be synthesized by humans, it needs to be obtained from the diet [ 161 ]. The nutritional deficiency of this vitamin, scurvy, possibly the first clinical trial ever made [ 162 ], was first described in sailors.…”

Section: Antioxidantsmentioning

confidence: 99%

Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress

Torres-Arce

Vizmanos

Babió

et al. 2021

Biology

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Infertility affects about 15% of the population and male factors only are responsible for ~25–30% of cases of infertility. Currently, the etiology of suboptimal semen quality is poorly understood, and many environmental and genetic factors, including oxidative stress, have been implicated. Oxidative stress is an imbalance between the production of free radicals, or reactive oxygen species (ROS), and the capacity of the body to counteract their harmful effects through neutralization by antioxidants. The purpose of this review, by employing the joint expertise of international researchers specialized in nutrition and male fertility areas, is to update the knowledge about the reproductive consequences of excessive ROS concentrations and oxidative stress on the semen quality and Assisted Reproduction Techniques (ART) clinical outcomes, to discuss the role of antioxidants in fertility outcomes, and finally to discuss why foods and dietary patterns are more innocuous long term solution for ameliorating oxidative stress and therefore semen quality results and ART fertility outcomes. Since this is a narrative review and not a systematic/meta-analysis, the summarized information in the present study should be considered cautiously.

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Cited by 2 publications

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Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress

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