Line-field parallel swept source interferometric imaging at up to 1  MHz

Fechtig, Daniel; Schmoll, Tilman; Grajciar, Branislav; Drexler, Wolfgang; Leitgeb, Rainer A.

doi:10.1364/ol.39.005333

Cited by 41 publications

(15 citation statements)

References 11 publications

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“…[8][9][10][11]). Similarly, an off-axis reference beam in FD-OCT can also resolve this ambiguity and was successfully applied to FF-SS-OCT for full-range imaging [12] and later to line-field OCT [13].…”

Section: Introductionmentioning

confidence: 99%

Off-axis reference beam for full-field swept-source OCT and holoscopy

Hillmann¹,

Spahr²,

Sudkamp³

et al. 2017

Opt. Express

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In numerous applications, Fourier-domain optical coherence tomography (FD-OCT) suffers from a limited imaging depth due to signal roll-off, a limited focal range, and autocorrelation noise. Here, we propose a parallel full-field FD-OCT imaging method that uses a swept laser source and an area camera in combination with an off-axis reference, which is incident on the camera at a small angle. As in digital off-axis holography, this angle separates autocorrelation signals and the complex conjugated mirror image from the actual signal in Fourier space. We demonstrate that by reconstructing the signal term only, this approach enables fullrange imaging, i.e., it increases the imaging depth by a factor of two, and removes autocorrelation artifacts. The previously demonstrated techniques of inverse scattering and holoscopy can then numerically extend the focal range without loss of lateral resolution or imaging sensitivity. The resulting, significantly enhanced measurement depth is demonstrated by imaging a porcine eye over its entire depth, including cornea, lens, and retina. Finally, the feasibility of in vivo measurements is demonstrated by imaging the living human retina.

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Section: Introductionmentioning

confidence: 99%

Off-axis reference beam for full-field swept-source OCT and holoscopy

Hillmann¹,

Spahr²,

Sudkamp³

et al. 2017

Opt. Express

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show abstract

“…To our knowledge, our experimental SNR of 113 dB is higher than that of the previously fastest parallel SD-OCT system (0.5 million lines/s, SNR of 78 dB) [5], and of the fastest flying-spot SD-OCT system (1 million lines/s, sensitivity of 71 dB) [3]. We also note that a parallel SS-OCT system was recently reported at 1 MHz line rate offering 90 dB [15]. …”

mentioning

confidence: 54%

High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

et al. 2016

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The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum (SC) source, in combination with parallel SD-OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4×0.5 mm2 at 1,024,000 lines/s with 2×14 μm resolution (axial×transverse) at a sensitivity of 113 dB. Imaging using the proposed system is demonstrated on highly differentiated human bronchial epithelial (hBE) cells to capture and spatially localize ciliary dynamics.

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“…Bonin et al demonstrated multi-MHz A-scan rate for full-field SS OCT with an expensive high-speed 2D camera. Fechtig et al 110,111 showed retinal LF SS OCT with off-shelve camera technology at up to 1-MHz A-scan rate. A particular advantage of parallel OCT is the exceptional lateral phase stability, enabling digital refocusing and aberration correction.…”

Section: Adaptive-optics Octmentioning

confidence: 99%