Line temporal focusing characteristics in transparent and scattering media

Dana, Hod; Kruger, Nimrod; Ellman, Aviv; Shoham, Sharon

doi:10.1364/oe.21.005677

Cited by 36 publications

(28 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25][26][27] In addition to the advantage of an improved axial resolution, the strong intensity confinement of SSTF enabled the precise ablation of transparent materials and the generation of circular microfluidic channels in glass. 28,29 Furthermore, the suitability of SSTF for tissue ablation by laser-induced optical breakdown has recently been shown.…”

Section: Introductionmentioning

confidence: 99%

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

et al. 2014

View full text Add to dashboard Cite

In recent years, femtosecond (fs)-lasers have evolved into a versatile tool for high precision micromachining of transparent materials because nonlinear absorption in the focus can result in refractive index modifications or material disruptions. However, when high pulse energies or low numerical apertures are required, nonlinear side effects such as self-focusing, filamentation or white light generation can decrease the modification quality. In this paper, we apply simultaneous spatial and temporal focusing (SSTF) to overcome these limitations. The main advantage of SSTF is that the ultrashort pulse is only formed at the focal plane, thereby confining the intensity distribution strongly to the focal volume and suppressing detrimental nonlinear side effects. Thus, we investigate the optical breakdown within a water cell by pump-probe shadowgraphy, comparing conventional focusing and SSTF under equivalent focusing conditions. The plasma formation is well confined for low pulse energies ,2 mJ, but higher pulse energies lead to the filamentation and break-up of the disruptions for conventional focusing, thereby decreasing the modification quality. In contrast, plasma induced by SSTF stays well confined to the focal plane, even for high pulse energies up to 8 mJ, preventing extended filaments, side branches or break-up of the disruptions. Furthermore, while conventional focusing leads to broadband supercontinuum generation, only marginal spectral broadening is observed using SSTF. These experimental findings are in excellent agreement with numerical simulations of the nonlinear pulse propagation and interaction processes. Therefore, SSTF appears to be a powerful tool to control the processing of transparent materials, e.g., for precise ophthalmic fs-surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

et al. 2014

View full text Add to dashboard Cite

show abstract

“…More significant problem is that the axial extent of the excitation volume is progressively broadened in a turbid medium as the imaging depth increases, which further increases the background noise [12]. Recently, it has been shown that this effect can be partly avoided by using the line focused TFM which maintains axial resolution even at 2.5 scattering mean free path (MFP) [13]. …”

Section: Introductionmentioning

confidence: 99%

Improvement of axial resolution and contrast in temporally focused widefield two-photon microscopy with structured light illumination

Choi

Yew

Hallacoglu

et al. 2013

Biomed. Opt. Express

View full text Add to dashboard Cite

Although temporally focused wide-field two-photon microscopy (TFM) can perform depth resolved wide field imaging, it cannot avoid the image degradation due to scattering of excitation and emission photons when imaging in a turbid medium. Further, its axial resolution is inferior to standard point-scanning two-photon microscopy. We implemented a structured light illumination for TFM and have shown that it can effectively reject the out-of-focus scattered emission photons improving image contrast. Further, the depth resolution of the improved system is dictated by the spatial frequency of the structure light with the potential of attaining depth resolution better than point-scanning two-photon microscopy.

show abstract

“…Although all analytical approaches rely on Fourier optics and Fresnel diffraction with slight variations and modifications 5,[11][12][13] , each approach has produced a different analytical expression composed of different parameters. In addition, other studies have employed numerical methods and fitted the results with different sectioning expressions consisting of yet another set of parameters 14,15 .…”

Section: Tf Theorymentioning

confidence: 99%

New insights and system designs for temporally focused multiphoton optogenetics

et al. 2015

Self Cite

View full text Add to dashboard Cite

Temporal focusing (TF) multiphoton systems constitute a powerful solution for cellular resolution optogenetic stimulation and recording in three-dimensional, scattering tissue. Here, we address two fundamental aspects in the design of such systems: first, we examine the design of TF systems with specific optical sectioning by comparatively analyzing previously published results. Next, we develop a solution for obtaining TF in a flexible three-dimensional pattern of cellmatched focal spots. Our solution employs spatio-temporal focusing (SSTF) in a unique optical system design that can be integrated before essentially any multiphoton imaging or stimulation system.

show abstract

Line temporal focusing characteristics in transparent and scattering media

Cited by 36 publications

References 23 publications

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing

Improvement of axial resolution and contrast in temporally focused widefield two-photon microscopy with structured light illumination

New insights and system designs for temporally focused multiphoton optogenetics

Contact Info

Product

Resources

About