Lineage-Specific Evolution of the Complex <i>Nup160</i> Hybrid Incompatibility Between <i>Drosophila melanogaster</i> and Its Sister Species

Tang, Shanwu; Presgraves, Daven C.

doi:10.1534/genetics.114.167411

Cited by 15 publications

(14 citation statements)

References 68 publications

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“…Remarkably, genetic analysis revealed that in the majority of tested cases the differences in essentiality were influenced by at least four different loci in the genome suggesting complex multigenic interactions (Dowell et al., ). Even the classical case of DMI in Drosophila is genetically complex, where hybrid lethality of Nup160 depends on one or more unknown additional factors in the autosomal background (Tang & Presgraves, ).…”

Section: Mechanistic Reasons For An Association Between Ecological Anmentioning

confidence: 99%

Intrinsic incompatibilities evolving as a by‐product of divergent ecological selection: Considering them in empirical studies on divergence with gene flow

Kulmuni

Westram

2017

Molecular Ecology

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The possibility of intrinsic barriers to gene flow is often neglected in empirical research on local adaptation and speciation with gene flow, for example when interpreting patterns observed in genome scans. However, we draw attention to the fact that, even with gene flow, divergent ecological selection may generate intrinsic barriers involving both ecologically selected and other interacting loci. Mechanistically, the link between the two types of barriers may be generated by genes that have multiple functions (i.e., pleiotropy), and/or by gene interaction networks. Because most genes function in complex networks, and their evolution is not independent of other genes, changes evolving in response to ecological selection can generate intrinsic barriers as a by-product. A crucial question is to what extent such by-product barriers contribute to divergence and speciation-that is whether they stably reduce gene flow. We discuss under which conditions by-product barriers may increase isolation. However, we also highlight that, depending on the conditions (e.g., the amount of gene flow and the strength of selection acting on the intrinsic vs. the ecological barrier component), the intrinsic incompatibility may actually destabilize barriers to gene flow. In practice, intrinsic barriers generated as a by-product of divergent ecological selection may generate peaks in genome scans that cannot easily be interpreted. We argue that empirical studies on divergence with gene flow should consider the possibility of both ecological and intrinsic barriers. Future progress will likely come from work combining population genomic studies, experiments quantifying fitness and molecular studies on protein function and interactions.

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Section: Mechanistic Reasons For An Association Between Ecological Anmentioning

confidence: 99%

Intrinsic incompatibilities evolving as a by‐product of divergent ecological selection: Considering them in empirical studies on divergence with gene flow

Kulmuni

Westram

2017

Molecular Ecology

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“…Nup96 and Nup160 are also involved in reproductive isolation ( Presgraves et al 2003 ; Tang and Presgraves 2009 ; Sawamura et al 2010 ). Nup96 sim and Nup160 sim synergistically cause hybrid incompatibility ( Sawamura et al 2014 ), but the D. melanogaster alleles of Nup160 and Nup96 are not the dominant autosomal incompatibility partner of Nup96 sim and Nup160 sim , respectively ( Tang and Presgraves 2015 ). Then, what is (are) the incompatibility partner(s) of Nup96 sim and Nup160 sim ?…”

Section: Discussionmentioning

confidence: 99%

Genetic Analyses ofElysMutations inDrosophilaShow Maternal-Effect Lethality and Interactions withNucleoporinGenes

Hirai

Wang

Miura

et al. 2018

G3 Genes|Genomes|Genetics

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ELYS determines the subcellular localizations of Nucleoporins (Nups) during interphase and mitosis. We made loss-of-function mutations of Elys in Drosophila melanogaster and found that ELYS is dispensable for zygotic viability and male fertility but the maternal supply is necessary for embryonic development. Subsequent to fertilization, mitotic progression of the embryos produced by the mutant females is severely disrupted at the first cleavage division, accompanied by irregular behavior of mitotic centrosomes. The Nup160 introgression from D. simulans shows close resemblance to that of the Elys mutations, suggesting a common role for those proteins in the first cleavage division. Our genetic experiments indicated critical interactions between ELYS and three Nup107–160 subcomplex components; hemizygotes of either Nup37, Nup96 or Nup160 were lethal in the genetic background of the Elys mutation. Not only Nup96 and Nup160 but also Nup37 of D. simulans behave as recessive hybrid incompatibility genes with D. melanogaster. An evolutionary analysis indicated positive natural selection in the ELYS-like domain of ELYS. Here we propose that genetic incompatibility between Elys and Nups may lead to reproductive isolation between D. melanogaster and D. simulans, although direct evidence is necessary.

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“…When subsequently examined in crosses between D. melanogaster and D. mauritiana or D. sechellia, the D. melanogaster Nup96 incompatibility only occured in crosses with D. sechellia and not D. mauritiana (Barbash 2007). Similarly, sequence differences in Nup160 between D. simulans and D. mauritiana, as well as differences in the autosomal background of these species, modulate the strength of hybrid inviability in crosses with D. melanogaster (Tang and Presgraves 2015).…”

Section: Postzygotic Isolationmentioning

confidence: 99%

Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies in Drosophila

Castillo¹,

Barbash

2017

Genetics

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The question of how new species evolve has been examined at every level, from macroevolutionary patterns of diversification to molecular population genetic analyses of specific genomic regions between species pairs. has been at the center of many of these research efforts. Though our understanding of the speciation process has grown considerably over the past few decades, very few genes have been identified that contribute to barriers to reproduction. The development of advanced molecular genetic and genomic methods provides promising avenues for the rapid discovery of more genes that contribute to speciation, particularly those involving prezygotic isolation. The continued expansion of tools and resources, especially for species other than, will be most effective when coupled with comparative approaches that reveal the genetic basis of reproductive isolation across a range of divergence times. Future research programs in have high potential to answer long-standing questions in speciation. These include identifying the selective forces that contribute to divergence between populations and the genetic basis of traits that cause reproductive isolation. The latter can be expanded upon to understand how the genetic basis of reproductive isolation changes over time and whether certain pathways and genes are more commonly involved.

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Lineage-Specific Evolution of the Complex Nup160 Hybrid Incompatibility Between Drosophila melanogaster and Its Sister Species

Cited by 15 publications

References 68 publications

Intrinsic incompatibilities evolving as a by‐product of divergent ecological selection: Considering them in empirical studies on divergence with gene flow

Intrinsic incompatibilities evolving as a by‐product of divergent ecological selection: Considering them in empirical studies on divergence with gene flow

Genetic Analyses ofElysMutations inDrosophilaShow Maternal-Effect Lethality and Interactions withNucleoporinGenes

Moving Speciation Genetics Forward: Modern Techniques Build on Foundational Studies in Drosophila

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