Linear Epidermal Nevus with Acantholytic Dyskeratosis in an Infant

Yasutomi, Hiroshi; Arakawa, Kiyoshi; Akagi, Osamu; Miyashita, Masato; Arata, Jirô

doi:10.1111/j.1346-8138.1990.tb01699.x

Cited by 4 publications

(2 citation statements)

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“…The four major patterns of acantholysis are mainly defined by the level of clefting and include: (i) the acantholytic dyskeratotic pattern of Darier’s disease; (ii) acantholysis in the entire epidermis as observed in Hailey–Hailey disease; and (iii) a suprabasal (vulgaris); as well as (iv) a superficial (seborrhoeic) type of pemphigus pattern 1 . These variants may be observed not only in the classical dermatoses that coined the term but also in various other skin diseases such as Grover’s disease, acantholytic acanthoma, 2 warty dyskeratoma, 3 linear epidermal naevus, 4 naevus corniculatus, 5 oral focal dyskeratosis 6 and acantholytic dermatosis localized to the vulvocrural area 7 . All patterns of acantholysis may also occur as an incidental histopathological finding, remaining subclinical in many inflammatory and neoplastic skin diseases, for example: leucocytoclastic vasculitis, 1 pityriasis rosea, chondrodermatitis nodularis helicis, 8 dermatofibroma, 9 basal cell carcinoma 1 and also in acral lentiginous malignant melanoma 10 .…”

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A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

et al. 2001

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We report a 72-year-old male patient with a nodular malignant melanoma that was associated with focal suprabasal acantholysis (FSA). This phenomenon, which is regarded as an incidental finding by dermatopathologists, may be associated with inflammatory and also neoplastic skin diseases. Haematoxylin and eosin stained sections from an erythematous plaque surrounding the patient's tumour showed FSA, direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) on normal human skin, monkey oesophagus and rat urinary bladder were negative. On electron microscopy few desmosomes could be detected in the basal cell layer of the acantholytic areas and there was a nearly complete loss of these structures in the spinous cell layer. Only remnants of cytoplasmic plaques and keratin filaments could be observed in those areas. In contrast, adherens junctions appeared to be well preserved. An enzyme-linked immunosorbent assay (ELISA) using recombinant fusion proteins as antigens did not show circulating autoantibodies against desmoglein 1 (Dsg1) or desmoglein 3 (Dsg3). In contrast, immunoblotting revealed autoantibodies directed against keratinocyte antigens with a molecular weight of 85 kDa and 250 kDa, the first band corresponding to the molecular weight of comigrating plakoglobin. Immunoprecipitation with patient serum also revealed a 85-kDa band. We conclude that these autoantibodies, probably in conjunction with cofactors produced by the tumour, could play a part in the pathogenesis of this variant of FSA, for which we propose the term 'localized paraneoplastic pemphigus.'

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A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma

et al. 2001

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“…Various names have been given to this disease; nevus unius lateris, verrucous nevus, or linear nevus [4,9]. This lesion is usually noted at birth or shortly after, and consists of skin-colored to brownish, slightly elevated, wart-like patches on the face, scalp, neck, thorax, and extremities.…”

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confidence: 99%