Linear focal elastosis in a young black man: A new presentation

Acquired disorders of elastic tissue: part I. increased elastic tissue and solar elastotic syndromes

“…Lesions may occur on the axillae, abdomen, thighs, arms, or breasts, and histopathologic examination shows a flattened epidermis, abnormal collagen fibers, and variable changes in elastic tissue. 7,19 By contrast, linear focal elastosis is characterized by palpable yellow plaques that show characteristic changes in elastic tissue; the epidermis and collagen fibers are not affected. Notably, coexistence of these two lesions has been reported.…”

“…6 By 30 years of age, the concentration of microfibrils has dropped significantly; by age 60, elastic fibers are predominantly elastin. 7 Cutaneous elastin and microfibrillar glycoproteins are synthesized primarily by fibroblasts. Elastin is initially secreted as tropoelastin, which is crosslinked with and stabilized by desmosine to form elastin.…”

Linear Focal Elastosis in a Family

“…2 The occurrence of LFE in families has led to a suggestion of genetic basis in the development of LFE as is evident by the clustering of cases of LFE in a single family. Till date only three case reports of LFE with familial occurrence has been reported; one in a father and son and other in twins, 3,4 the third one in a brother and sister. 5 To the best of our knowledge there are no case reports of presence of LFE in three successive generations.…”

A Case of Linear Focal Elastosis with a Family History

“…Histopathologically it can be seen as having deposition of abnormal elastic fibers in the dermis [1][2][3] . Until now, only 2 cases of linear focal elastosis with a family history have been reported 4,5 . Here, we present one such case, of linear focal elastosis with a family history.…”