Linear growth and anthropometric and nutritional measurements in children with mild to moderate renal insufficiency: A report of the growth failure in children with renal diseases study

Abitbol, Carolyn; Warady, Bradley A.; Massie, Martha D.; Baluarte, H. Jorge; Fleischman, Larry E.; Geary, Denis F.; Kaiser, Bruce A.; McEnery, Paul T.; Chan, James C.M.

doi:10.1016/s0022-3476(05)82925-7

Cited by 47 publications

(22 citation statements)

References 24 publications

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“…The body weight is less affected than height in the present study. This agrees with other studies reported that no significant deficit in body weight has been found in studies of children with CKD [20]. Also, the mean z-score of mid upper arm circumference triceps and subscapular skinfold thicknesses were slightly reduced.…”

Section: Discussionsupporting

confidence: 92%

Nutritional Status in Children with Chronic Renal Failure on Hemodialysis

2012

Maced J Med Sci

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Section: Discussionsupporting

confidence: 92%

Nutritional Status in Children with Chronic Renal Failure on Hemodialysis

2012

Maced J Med Sci

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“…Multiple factors have been identified contributing to growth retardation: young age at the start of CKD, congenital CKD, insufficient caloric intake, acidosis, and renal osteodystrophy with hyperparathyroidism [1]. …”

Section: Introductionmentioning

confidence: 99%

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Mericq

Salas²,

Pinto³

et al. 2013

Horm Res Paediatr

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Background: Glucocorticoid immunosuppressant therapy in pediatric kidney transplant (Tx) recipients does not allow the improvement of growth after Tx. Objective: To determine the effect of early steroid withdrawal (SW) on longitudinal growth, insulin sensitivity (IS), and body composition (BC). Methods: This was a prospective, randomized, multicenter study in Tx. Insulin-like growth factor (IGF)-I, IGF-binding protein 3 (IGFBP3), IS, and BC (DEXA/pQCT) were determined at baseline and up to 12 months after Tx. Results: A total of 30 patients were examined; 14 patients were assigned to the SW group (7 male, 7 female; 12 in Tanner stage I) and 16 patients were assigned to the steroid control (SC) group (10 male, 6 female;12 in Tanner stage I). Their chronological age was 7.8 ± 4.3 years, height was -2.3 ± 0.99 SD scores (SDS), and body mass index -0.3 ± 1.2 SDS. After 1 year, the SW group showed an increase in height SDS (+1.2 ± 0.22 vs. +0.60 ± 0.13 SDS in the SC group, p < 0.02), lower IGFBP3 (p < 0.05), cholesterol (p < 0.05), and higher high-density lipoprotein cholesterol (p < 0.05). SW patients had lower trunk fat with no differences in IS. Only in prepubertal patients, the SW group had lower glycemia (p < 0.05), very low-density lipoprotein cholesterol (p < 0.01), triglycerides (p < 0.05), triglycerides/glycemia index (TyG; p < 0.02), and better lean mass. Both groups showed an improvement in lean mass after kidney Tx. Conclusions: SW improved longitudinal growth, lipid profile, and trunk and lean fat in Tx patients. In prepubertal recipients, the decrease in TyG suggests better IS.

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“…The disturbance in the growth pattern observed in pediatric patients with CKD is due to a variety of factors, such as malnutrition, anemia, metabolic acidosis and hormonal disorders [1]. The age at onset of kidney disease plays a major role, and the loss of relative height is greatest in the first year of life [2,3]. Puberty is frequently delayed in adolescents with CKD, and the total pubertal height gain is reduced.…”

Section: Introductionmentioning

confidence: 99%

Growth impairment shows an age-dependent pattern in boys with chronic kidney disease

et al. 2007

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The impact of chronological age on longitudinal body growth from early childhood through adolescence using detailed anthropometric methods has not yet been studied in children with chronic kidney disease (CKD). We have evaluated growth failure by measuring four components of linear growth: body height (HT), sitting height (SHT), arm length (AL) and leg length (LL). Data were prospectively collected for up to 7 years on 190 boys (3-21 years old) with congenital or hereditary CKD (all had developed at least stage 2 CKD by the age of 10 years). Patients showed the most severe growth failure in early childhood, followed by an acceleration in growth in pre-puberty, a slowing-down of growth at puberty, as expected, and thereafter a late speeding-up of growth until early adulthood. This pattern was observed irrespective of the degree of CKD and different treatment modalities, such as conservative treatment, recombinant human growth hormone (rhGH) therapy or transplantation. LL showed the most dynamic growth changes of all the parameters evaluated and emerged as the best indicator of statural growth in children with CKD. A specific age-dependent pattern of physical growth was identified in pediatric male CKD patients. This growth pattern should be considered in the evaluation of individual growth and the assessment of treatment efficacy such as rhGH therapy.

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Linear growth and anthropometric and nutritional measurements in children with mild to moderate renal insufficiency: A report of the growth failure in children with renal diseases study

Cited by 47 publications

References 24 publications

Nutritional Status in Children with Chronic Renal Failure on Hemodialysis

Nutritional Status in Children with Chronic Renal Failure on Hemodialysis

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial

Growth impairment shows an age-dependent pattern in boys with chronic kidney disease

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