Linear Growth of Low-Dose Cyclosporin A Therapy in Children with Steroid-Dependent Nephrotic Syndrome

Kano, Kenichi; Nishikura, Kiyoshi; Hoshi, Megumi; Yamada, Yumi; Arisaka, Osamu

doi:10.1159/000045933

Cited by 3 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although steroid regimens used in children with SSNS do not usually have a significant impact on growth [6,[11][12][13][14][15], severe growth retardation has been reported in children with steroiddependent or frequently relapsing nephrotic syndrome, especially in boys [13,14,16]. Studies specifically investigating the linear growth of children with severe SDNS treated with long-term CsA and steroid combination therapy are scarce [17,18]. Therefore, we analyzed statural growth in male patients with SDNS undergoing long-term CsA and steroid therapy.…”

Section: Introductionmentioning

confidence: 99%

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

et al. 2009

View full text Add to dashboard Cite

Although steroid-free remission can usually be achieved with cyclosporin A (CsA) in patients with steroid-dependent nephrotic syndrome (SDNS), some CsA-treated patients require long-term steroid therapy. Data on growth in these patients are scarce. Sixty-four boys with SDNS receiving long-term CsA and steroid therapy were retrospectively analyzed. During the 10-year follow-up period, height standard deviation score (HSDS) remained in the normal range in 47 patients but was below -2 SD in 17 patients. The occurrence of growth retardation was influenced by height at diagnosis and the number of relapses. Thirty patients were followed for at least 3 years before and after age 12. The decrease in HSDS per year of disease in patients older than 12 years was twice that observed in children younger than 12. However, adult height was < or = -2 SD in only two of the 14 patients reaching adult height, reflecting potential catch-up growth during late puberty. Careful monitoring of growth is recommended, given than up to 25% of patients experienced severe growth retardation during the course of their disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In the present study, the effect of GC combined with CsA treatment on the linear growth of nephrotic patients did not differ from that of treatment with GC alone. Results of two previous studies suggested that CsA therapy had no harmful effect, and indeed had a positive effect, on linear growth 4,9) . Kano et al reported that the height Z scores of 8 boys with SDNS had increased by 0.4 SD at 1 year after the start of CsA therapy and by 0.7 SD at 2 years after the start of CsA therapy 9) .…”

Section: Discussionmentioning

confidence: 97%

“…Results of two previous studies suggested that CsA therapy had no harmful effect, and indeed had a positive effect, on linear growth 4,9) . Kano et al reported that the height Z scores of 8 boys with SDNS had increased by 0.4 SD at 1 year after the start of CsA therapy and by 0.7 SD at 2 years after the start of CsA therapy 9) . Moreover, the degree of increase in height Z score since the start of CsA therapy was greater than that since the cessation of prednisolone, which was supported by increases in serum alkaline phosphatase and urinary GH concentrations after the start of CsA therapy 9) .…”

Section: Discussionmentioning

confidence: 97%

“…Kano et al reported that the height Z scores of 8 boys with SDNS had increased by 0.4 SD at 1 year after the start of CsA therapy and by 0.7 SD at 2 years after the start of CsA therapy 9) . Moreover, the degree of increase in height Z score since the start of CsA therapy was greater than that since the cessation of prednisolone, which was supported by increases in serum alkaline phosphatase and urinary GH concentrations after the start of CsA therapy 9) . Ishikura et al reported that the linear growth of patients with relapsing nephrotic syndrome was maintained or slightly improved during 2 years of follow up after 2 years of CsA ad- Δheight Z score/year -0.06 (-0.42-0.11) -0.01 (-0.08-0.06) 0.262…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

Lee

Kim

et al. 2016

Child Kidney Dis

View full text Add to dashboard Cite

This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS). Methods: Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorticoid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen patients were treated with GC alone and 18 were treated with GC and CsA. The cumulative doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (Δ height Z score/year). The associations between linear growth and clinical parameters were analyzed. Results: The linear growth of patients in the two groups was not significantly different (P=0.262). The Δ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumulative dose of GC and positively correlated with the Z score for height at the time of diagnosis. Conclusion: In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.

show abstract

Long-term effects of cyclophosphamide therapy in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome

Cammas

Harambat

Bertholet‐Thomas

et al. 2010

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

show abstract

Linear Growth of Low-Dose Cyclosporin A Therapy in Children with Steroid-Dependent Nephrotic Syndrome

Cited by 3 publications

References 5 publications

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment

The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

Long-term effects of cyclophosphamide therapy in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome

Contact Info

Product

Resources

About