Linear IgA bullous dermatosis in a patient with renal cell carcinoma

Abstract

Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal bullous disease with heterogeneous clinical manifestations, characterized by linear deposition of IgA along the epidermal basement membrane zone. We report a patient with a metastasized renal cell carcinoma who developed an extensive blistering eruption. The lesions showed immunopathological findings characteristic of LABD. The patient showed a fair response to prednisolone and dapsone. Treatment to control the LABD was no longer required when interferon-alfa was started as palliative therapy for the metastasized renal cell carcinoma. The association of LABD and malignancies has been documented before and is not due to mere chance alone.

Diagnosis of epidermoid lung carcinoma in a patient presenting with skin lesions

“…Tense vesicles and bullae, sometimes in an arcuate or linear pattern are seen on trunk and limbs but generalized blistering is a rare finding as the clinical feature. Mucosal involvement of oral cavity is frequent in adults ( Van der Waal et al, 2001). In our case, tense bullae annular in shape were present with a tendency to increase in number despite the medical treatment.…”

Otoimmün büllü hastalıklar ve paraneoplazi

“…Mesane veya renal kanser gibi solid neoplaziler ile birliktelik gösteren olgular da yayınlanmıştır 34,35 . Bununla birlikte malinite açısından yüksek riskli bir büllöz hastalık olarak kabul edilmemektedir.…”

IgA Nephropathy Coexisting with Linear IgA Bullous Disease

“…1 An increased incidence of glomerulonephritis has been reported in patients with autoimmune bullous disease. Here, we report a patient with LABD developing IgA nephropathy (IgAN).…”