Linear Path Integration Deficits in Patients with Abnormal Vestibular Afference

Arthur, Joeanna C.; Kortte, Kathleen B.; Shelhamer, Mark; Schubert, Michael C.

doi:10.1163/187847612x629928

Cited by 14 publications

(6 citation statements)

References 55 publications

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“…34,35 Previous studies have demonstrated the important role of vestibular cues in path integration. 36,37 Our previous study included conditions in which normally sighted subjects were pushed in a wheelchair along the three-segment paths to determine if reduced proprioceptive input would result in poorer spatial updating. 13 The wheelchair subjects did not exhibit poorer updating performance than the walking subjects, nor did they show greater dependence on visual condition.…”

Section: Discussionmentioning

confidence: 99%

Indoor Spatial Updating With Impaired Vision

Legge

Granquist

Baek

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeSpatial updating is the ability to keep track of position and orientation while moving through an environment. We asked how normally sighted and visually impaired subjects compare in spatial updating and in estimating room dimensions.MethodsGroups of 32 normally sighted, 16 low-vision, and 16 blind subjects estimated the dimensions of six rectangular rooms. Updating was assessed by guiding the subjects along three-segment paths in the rooms. At the end of each path, they estimated the distance and direction to the starting location, and to a designated target. Spatial updating was tested in five conditions ranging from free viewing to full auditory and visual deprivation.ResultsThe normally sighted and low-vision groups did not differ in their accuracy for judging room dimensions. Correlations between estimated size and physical size were high. Accuracy of low-vision performance was not correlated with acuity, contrast sensitivity, or field status. Accuracy was lower for the blind subjects. The three groups were very similar in spatial-updating performance, and exhibited only weak dependence on the nature of the viewing conditions.ConclusionsPeople with a wide range of low-vision conditions are able to judge room dimensions as accurately as people with normal vision. Blind subjects have difficulty in judging the dimensions of quiet rooms, but some information is available from echolocation. Vision status has little impact on performance in simple spatial updating; proprioceptive and vestibular cues are sufficient.

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Section: Discussionmentioning

confidence: 99%

Indoor Spatial Updating With Impaired Vision

Legge

Granquist

Baek

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…Compared with the healthy subjects, the patients with VHF showed a larger rotation angle (MRT), suggesting enhanced sudden movement of the chest and pelvis during the current task. The unexpectedly exaggerated trunk rotation and body deviation (indicated by the MLW and XCoB) in the VHF patients during the test could be induced by overestimation and overreaction related to abnormal vestibular function (46)(47)(48) and may consume more energy. However, there were no apparent differences in head motion between the healthy subjects and BVH patients.…”

Section: Trunk Rotation and Body Trajectory (Indicated By The Mrt MLmentioning

confidence: 99%

Development of a Computerized Device for Evaluating Vestibular Function in Locomotion: A New Evaluation Tool of Vestibular Hypofunction

Chen

Chou²,

Jheng

et al. 2020

Front. Neurol.

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To evaluate vestibular function in the clinic, current assessments are applied under static conditions, such as with the subject in a sitting or supine position. Considering the complexities of daily activities, the combination of dynamic activities, dynamic visual acuity (DVA) and postural control could produce an evaluation that better reflects vestibular function in daily activities. Objective: To develop a novel sensor-based system to investigate DVA, walking trajectory, head and trunk movements and the chest-pelvis rotation ratio during forward and backward overground walking in both healthy individuals and patients with vestibular hypofunction. Methods: Fifteen healthy subjects and 7 patients with bilateral vestibular hypofunction (BVH) were recruited for this study. Inertial measurement units were placed on each subject's head and torso. Each subject walked forward and backward for 5 m twice with 2 Hz head yaw. Our experiment comprised 2 stages. In stage 1, we measured forward (FW), backward (BW), and medial-lateral (MLW) walking trajectories; head and trunk movements; and the chest-pelvis rotation ratio. In stage 2, we measured standing and locomotion DVA (loDVA). Using Mann-Whitney U-test, we compared the abovementioned parameters between the 2 groups. Results: Patients exhibited an in-phase chest/pelvis reciprocal rotation ratio only in FW. The walking trajectory deviation, calculated by normalizing the summation of medial-lateral swaying with 1/2 body height (%), was significantly larger (FW mean ± standard deviation: 20.4 ± 7.1% (median (M)/interquartile range (IQR): 19.3/14.4-25.2)in healthy vs. 43.9 ± 27. 3% (M/IQR: 36.9/21.3-56.9) in patients, p = 0.020)/(BW mean ± standard deviation: 19.2 ± 11.5% (M/IQR: 13.6/10.4-25.3) in healthy vs. 29.3 ± 6.4% (M/IQR: 27.7/26.5-34.4) in patients, p = 0.026), and the walking DVA was also significantly higher (LogMAR score in the patient group [FW LogMAR: rightDVA: mean ± standard deviation

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“…Second, unlike time-varying actions that characterize navigation under natural conditions, participants’ responses were often reduced to single, binary end-of-trial decisions ( ter Horst et al, 2015 ; Chrastil et al, 2016 ; Koppen et al, 2019 ). Third, even studies that explored contributions of different sensory modalities in naturalistic settings failed to properly disentangle vestibular from motor cues generated during active locomotion ( Kearns et al, 2002 ; Campos et al, 2010 ; Bergmann et al, 2011 ; Chen et al, 2017 ; Schubert et al, 2012 ; Péruch et al, 1999 ; Péruch et al, 2005 ). Furthermore, varying constraints have presumably resulted in inconsistent findings on the contribution of vestibular cues to path integration ( Jürgens and Becker, 2006 ; Campos et al, 2010 ; ter Horst et al, 2015 ; Tramper and Medendorp, 2015 ; Koppen et al, 2019 ; Chrastil et al, 2019 ; Glasauer et al, 1994 ; Seidman, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of sensory modality and control dynamics on human path integration

Stavropoulos

Lakshminarasimhan

Laurens

et al. 2022

eLife

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Path integration is a sensorimotor computation that can be used to infer latent dynamical states by integrating self-motion cues. We studied the influence of sensory observation (visual/vestibular) and latent control dynamics (velocity/acceleration) on human path integration using a novel motion-cueing algorithm. Sensory modality and control dynamics were both varied randomly across trials, as participants controlled a joystick to steer to a memorized target location in virtual reality. Visual and vestibular steering cues allowed comparable accuracies only when participants controlled their acceleration, suggesting that vestibular signals, on their own, fail to support accurate path integration in the absence of sustained acceleration. Nevertheless, performance in all conditions reflected a failure to fully adapt to changes in the underlying control dynamics, a result that was well explained by a bias in the dynamics estimation. This work demonstrates how an incorrect internal model of control dynamics affects navigation in volatile environments in spite of continuous sensory feedback.

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Linear Path Integration Deficits in Patients with Abnormal Vestibular Afference

Cited by 14 publications

References 55 publications

Indoor Spatial Updating With Impaired Vision

Indoor Spatial Updating With Impaired Vision

Development of a Computerized Device for Evaluating Vestibular Function in Locomotion: A New Evaluation Tool of Vestibular Hypofunction

Influence of sensory modality and control dynamics on human path integration

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