Linear self-assembly formation between gold nanoparticles and aminoglycoside antibiotics

Zheng, Tianyu; Sip, Yuen Yee Li; Leong, Michael; Huo, Qun

doi:10.1016/j.colsurfb.2018.01.027

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…Gold nanoparticles are widely acknowledged as attractive drug delivery possibilities because of their unique dimensions, varying surface functionalities, and regulated drug release. 22 The mixture of gold nanoparticles (AuNPs) and negative citrate ligands capped with polycationic ribostamycin aminoglycoside antibiotics showed unique properties. 22 The interaction between ribostamycin and AuNPs was examined at various doses using a combination of AuNPs of various sizes, and ribostamycin was determined using a dark-field optical microscopic study.…”

Section: Aminoglycoside-coated Silver Nanoparticlesmentioning

confidence: 99%

“…22 The mixture of gold nanoparticles (AuNPs) and negative citrate ligands capped with polycationic ribostamycin aminoglycoside antibiotics showed unique properties. 22 The interaction between ribostamycin and AuNPs was examined at various doses using a combination of AuNPs of various sizes, and ribostamycin was determined using a dark-field optical microscopic study. Ribostamycin formed linear oligomers at higher concentrations, resulting in the formation of rod-like negative AuNPs.…”

Section: Aminoglycoside-coated Silver Nanoparticlesmentioning

confidence: 99%

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Antibacterial Efficacies of Nanostructured Aminoglycosides

Bera

Mondal

2022

ACS Omega

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The widespread use of broad-spectrum aminoglycoside antibiotics is restricted from various clinical applications due to the emergence of bacterial resistance and the adverse effects such as ototoxicity and nephrotoxicity. The intensive applicability of nanoparticles in modern medicinal chemistry has gained the interest of researchers for modification of aminoglycosides as nanoconjugates either via covalent conjugation or physical interactions to alleviate their undesirable effects and bacterial resistance. In this context, various carbohydrates, polymers, lipids, silver, gold, and silica-attached aminoglycoside nanoparticles have been reported with improvements in physicochemical properties, bioavailability, and biocompatibility in physiological medium. Overall, this review encompassed the synthesis of nanostructured aminoglycosides and their applications in the development of new antibacterial therapeutics.

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Section: Aminoglycoside-coated Silver Nanoparticlesmentioning

confidence: 99%

Section: Aminoglycoside-coated Silver Nanoparticlesmentioning

confidence: 99%

Antibacterial Efficacies of Nanostructured Aminoglycosides

Bera

Mondal

2022

ACS Omega

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“…Upon the addition of kanamycin (kana) at 10 μM and 20 μM, the color of AgNPs@β-CD changed to orange and dark red, respectively. This result proves that the formation of nanocomposites could be possibly due to the easy binding of the positively charged -NH 2 group of AMGs to AgNPs@β-CD via hydrogen bond/columbic interaction/ polar interactions [38]. AgNPs@β-CD and nanocomposites were characterized by UV-Vis spectra and transmission electron microscope (TEM) imaging.…”

Section: Resultsmentioning

confidence: 64%

Array-based microbial identification upon extracellular aminoglycoside residue sensing

Liu

et al. 2021

Anal Bioanal Chem

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Sensitive and rapid identification of pathogenic microorganisms is of great importance for clinical diagnosis and treatment. In this study, we developed an ultrasensitive colorimetric sensor array (CSA) based on the interactions between aminoglycoside antibiotics (AMGs) and Ag nanoparticles decorated with β-cyclodextrin (AgNPs@β-CD) to discriminate microorganisms quickly and accurately. Microorganisms can absorb different amounts of AMGs after incubation. Upon the addition of AgNPs@β-CD, the corresponding extracellular AMG residues will bind to AgNPs@β-CD, leading to color changes due to the modifications in localized surface plasmon resonance. The array was developed using 4 AMGs as sensing elements and AgNPs@β-CD as the colorimetric probe to generate a unique colorimetric response pattern for each microorganism. Standard chemometric methods indicated excellent discrimination among 20 microorganisms at low concentrations of 2 × 10 6 CFU/mL. Therefore, this ultrasensitive CSA can be used for microbial discrimination portably and efficiently. Importantly, the concentration of microbial discrimination by our array is much lower than that of prior CSAs. This method of extracellular residue sensing also provided a new strategy to improve the sensitivity of conventional CSA in the discrimination of microorganisms, to measure the amount of intercellular uptake of AMGs by microorganisms, and to screen drugs that can easily be accumulated by the pathogenic microorganisms. Keywords UV/VIS . Optical sensors . Nanoparticles . Bioanalytical methods . Biomedical analysis Published in the topical collection Analytical Chemistry for Infectious Disease Detection and Prevention with guest editors Chaoyong Yang and XiuJun (James) Li.

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“…aminoglycoside antibiotics) can trigger nanoparticle aggregation. [21] Critical patients often show higher lactic acid levels that could lead to small differences in pH, [22] which is known to modulate nanoparticle aggregation. [7] , [23] To demonstrate that proteins, and not other solutes in plasma, are the key to the observed changes in aggregation behavior, we repeated the same experiments with deproteinized plasma samples from 3 ICU and 3 ward patients.…”

Section: Resultsmentioning

confidence: 99%