Linezolid—A Review of Analytical Methods in Pharmaceuticals and Biological Matrices

Kokilambigai, K S; Lakshmi, K. S.; Susmitha, A Sai; Seetharaman, R; Kavitha, J.

doi:10.1080/10408347.2019.1599709

Cited by 12 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although linezolid concentrations in CSF have been widely reported in literature, in patients treated for gram-positive bacterial infections, the methods used for quantification have been less widely reported [ 24 , 25 ]. Many of the methods used ultraviolet–visible (UV–vis) spectrophotometry for detection, which is less sensitive than the method described in this article.…”

Section: Resultsmentioning

confidence: 99%

Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis

Mazanhanga,

Joubert,

Castel

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis

Mazanhanga,

Joubert,

Castel

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Several methods have been conducted to determine AMD alone and with other drugs in its pure form and commercial samples: the redox titrimetric method [15], spectrophotometric methods [16][17][18], spectrofluorimetric methods [17,[19][20][21][22][23][24][25][26][27][28], high-performance liquid chromatography [29][30][31][32], thin layer chromatography [30], electroanalytical methods [31,33], and capillary electrophoretic methods [34,35]. Kokilambigai et al have provided a good review of the different analytical methods for determining AMD [36].…”

Section: Introduction and Prefacementioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

View full text Add to dashboard Cite

The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

show abstract

“…The first oxazolidinone clinically available was Linezolid (LNZ), discovered in 1996 and approved in 2000 for clinical use by the FDA (U.S. Food and Drug Administration) [ 11 ]. LNZ is widely employed for GPB infections and it is considered an efficient drug for surgical infections [ 11 , 12 ] and in the treatment of drug-resistant pulmonary infections and MDR-TB infections. Among oxazolidinones, only LNZ and Tedizolid are clinically approved for MDR-TB infections.…”

Section: Introductionmentioning

confidence: 99%

Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

et al. 2021

View full text Add to dashboard Cite

This review covers the main aspects concerning the chemistry, the biological activity and the analytical determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clinical use over the past 50 years. They are characterized by a chemical structure including the oxazolidone ring with the S configuration of substituent at C5, the acylaminomethyl group linked to C5 and the N-aryl substituent. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Here, the main features of oxazolidinone antibiotics licensed or under development, such as Linezolid, Sutezolid, Eperezolid, Radezolid, Contezolid, Posizolid, Tedizolid, Delpazolid and TBI-223, are discussed. As they are protein synthesis inhibitors active against a wide spectrum of multidrug-resistant Gram-positive bacteria, their biological activity is carefully analyzed, together with the drug delivery systems recently developed to overcome the poor oxazolidinone water solubility. Finally, the most employed analytical techniques for oxazolidinone determination in different matrices, such as biological fluids, tissues, drugs and natural waters, are reviewed. Most are based on HPLC (High Performance Liquid Chromatography) coupled with UV-Vis or mass spectrometer detectors, but, to a lesser extent are also based on spectrofluorimetry or voltammetry.

show abstract

Linezolid—A Review of Analytical Methods in Pharmaceuticals and Biological Matrices

Cited by 12 publications

References 51 publications

Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis

Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

Contact Info

Product

Resources

About