Linezolid-Resistant<i>Staphylococcus cohnii,</i>Greece

Petinaki, Efi; Kanellopoulou, Maria; Damani, A.; Foka, Antigoni; Spiliopoulou, Iris; Skalmoutsou, Nikoletta; Raitsiou, Bogdan; Valakis, Konstantinos; Papafragas, E.

doi:10.3201/eid1501.080769

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…Further study of the S. epidermidis population structure is clearly needed. The case for a polyphyletic origin of Lin r S. epidermidis can be based simply on the observations that six of eight STs have the G2576T resistance mutation (Table 1) and that this mutation also occurs in different species of staphylococci and enterococci and is even reported to arise in vitro (23,26); it is therefore biologically plausible that this mutation could arise on multiple occasions within S. epidermidis. Alternatively, recombinations involving either MLST loci or resistance loci could have occurred.…”

Section: Discussionmentioning

confidence: 99%

Polyphyletic Emergence of Linezolid-Resistant Staphylococci in the United States

Wong

Reddy

Smyth

et al. 2010

Antimicrob Agents Chemother

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Section: Discussionmentioning

confidence: 99%

Polyphyletic Emergence of Linezolid-Resistant Staphylococci in the United States

Wong

Reddy

Smyth

et al. 2010

Antimicrob Agents Chemother

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“…As mentioned in other studies regarding multidrug-resistant pathogens, being hospitalized near an already colonized patient usually increases the chances of acquiring the microorganism. Prolonged ICU stay predisposes to infection, especially when patients receive linezolid as an anti-Gram-positive coverage [20,21]. …”

Section: Discussionmentioning

confidence: 99%

Factors Influencing Linezolid-Nonsusceptible Coagulase-Negative Staphylococci Dissemination Among Patients in the Intensive Care Unit: A Retrospective Cohort Study

Papadimitriou-Olivgeris

Giormezis

Fligou³

et al. 2013

Chemotherapy

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Background: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase-negative staphylococci (CNS) dissemination in the intensive care unit. Methods: Among the 246 patients included, 33 revealed a linezolid-nonsusceptible CNS-positive culture specimen, 68 were positive for linezolid-susceptible CNS and 145 served as controls. Isolates were characterized by phenotypic and genotypic methods to species level, susceptibility to antistaphylococcal agents and clones. Results: Among the 33 linezolid-nonsusceptible CNS patients, 29 revealed Staphylococcus epidermidis and 4 Staphylococcus capitis. All S. epidermidis strains belonged to the ST22 clone (by multilocus sequence typing), 26 carried both C2534T and T2504A and 3 strains were C2543T mutations. S. capitis strains were stratified as a common pulsed-field gel electrophoresis type and carried the G2576T mutation. Risk factors for linezolid-nonsusceptible CNS isolation were linezolid administration and mean number of linezolid-nonsusceptible CNS-positive patients in nearby beds per day. Conclusions: These results reinforce the aspect of rational antibiotic usage, but also highlight the need for strict infection control measures to prevent the dissemination of linezolid-nonsusceptible CNS.

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“…urealyticus in a Greek intensive care unit was reported, with septicemia in four patients; this was due to selection pressure through linezolid use in case of vancomycin-resistant Enterococcus faecium . 10 …”

Section: Discussionmentioning

confidence: 99%

Bacteremia due to Staphylococcus cohnii ssp. urealyticus caused by infected pressure ulcer: case report and review of the literature

Soldera¹,

Nedel

Cardoso

et al. 2013

Sao Paulo Med. J.

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CONTEXT: Coagulase-negative staphylococci are common colonizers of the human skin and have become increasingly recognized as agents of clinically significant nosocomial infections. CASE REPORT: The case of a 79-year-old male patient with multi-infarct dementia who presented systemic inflammatory response syndrome is reported. This was attributed to bacteremia due to Staphylococcus cohnii ssp. urealyticus, which was grown on blood cultures originating from an infected pressure ulcer. The few cases of Staphylococcus cohnii infection reported in the literature consist of bacteremia relating to catheters, surgical prostheses, acute cholecystitis, brain abscess, endocarditis, pneumonia, urinary tract infection and septic arthritis, generally presenting a multiresistant profile, with nearly 90% resistance to methicillin. CONCLUSIONS: The reported case is, to our knowledge, the first case of true bacteremia due to Staphylococcus cohnii subsp. urealyticus caused by an infected pressure ulcer. It shows that this species may be underdiagnosed and should be considered in the differential diagnosis for communityacquired skin infections. RESUMO CONTEXTO:Staphylococcus coagulase-negativos, colonizadores frequentes da pele humana, têm sido reconhecidos como agentes de infecções nosocomiais. RELATO DE CASO: Relata-se o caso de um paciente de 79 anos com demência vascular que apresentou síndrome da resposta inflamatória sistêmica atribuída a bacteremia por Staphylococcus cohnni ssp. urealyticus, que cresceu em hemoculturas, secundária a uma úlcera de pressão infectada. Os poucos casos de infecção por Staphylococcus cohnii relatados na literatura descrevem bacteremia associada a cateter, próteses cirúrgicas, colecistite aguda, abscesso cerebral, endocardite, pneumonia, infecção do trato urinário e artrite séptica, geralmente apresentando um perfil de multirresistência, com aproximadamente 90% de resistência à meticilina. CONCLUSÕES: O caso relatado é, ao nosso conhecimento, o primeiro de bacteremia verdadeira por Staphylococcus cohnii subsp. urealyticus causada por uma úlcera por pressão, mostrando que esta espécie pode estar subdiagnosticada e deveria ser considerada no diagnóstico diferencial das infecções cutâneas adquiridas na comunidade.

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Linezolid-ResistantStaphylococcus cohnii,Greece

Cited by 9 publications

References 9 publications

Polyphyletic Emergence of Linezolid-Resistant Staphylococci in the United States

Polyphyletic Emergence of Linezolid-Resistant Staphylococci in the United States

Factors Influencing Linezolid-Nonsusceptible Coagulase-Negative Staphylococci Dissemination Among Patients in the Intensive Care Unit: A Retrospective Cohort Study

Bacteremia due to Staphylococcus cohnii ssp. urealyticus caused by infected pressure ulcer: case report and review of the literature

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