Linfoma Intranasal Em Cão: Aspectos Clínicopatológicos E Imunoistoquímicos

Rodrigues, Ramon Tadeu Galvão Alves; Medeiros, Vítor Brasil; Borges, Igo Marinho Serafim; Oliveira, Zara Caroline Raquel de; Batista, Jael Soares; Filgueira, Kilder Dantas

doi:10.21708/avb.2016.10.1.5488

Cited by 2 publications

(7 citation statements)

References 17 publications

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“…Although the result of the immunohistochemical examination of the bitch of the present case defined the lymphoma as T-cell, in the literature the vast majority of canine lymphomas are described as being B-cells, representing 60-80% of the cases (PONCE et al, 2010;VEZZALI et al, 2010;RODRIGUES et al, 2016). Such reports may explain the good rates of clinical remission of lymphoma in most canine patients undergoing chemotherapy protocols, unlike the animal in the present report, in which the advanced stage of the disease resulted in an unfavorable outcome, without therapeutic perspectives, and the impossibility of determining the primary site of neoplasm.…”

Section: Case Reportmentioning

confidence: 71%

“…(RODRIGUES et al, 2016). Older animals, above seven years of age, constitute the most affected age group (NEUWALD et al, 2014;VILLAMIL et al, 2009).…”

Section: Case Reportmentioning

confidence: 99%

“…Both the fast evolution of clinical signs, which hindered the relationship between clinical pattern and neoplastic disease, and the simultaneous affection of several organ systems as shown in the necropsy, the lymphoma could not be classified anatomically as seen in the literature (RIBEIRO; ALEIXO; ANDRADE, 2015;RODRIGUES et al, 2016). Thus, determining the primary origin of the neoplasm was impossible, which justified considering the case in question as a CUP.…”

Section: Case Reportmentioning

confidence: 99%

“…Canine lymphoma is a hematopoietic neoplasm, characterized by the clonal proliferation of malignant lymphocytes, originating mainly in lymphoid organs, although different tissues of the organism may be affected (RODRIGUES et al, 2016;ZANDVLIET, 2016). Several classification methods are proposed for lymphoma according to neoplastic cell morphology, primary anatomical location, clinical stage, and immunophenotyping (MARCONATO; GELAIN;COMAZZI, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Several classification methods are proposed for lymphoma according to neoplastic cell morphology, primary anatomical location, clinical stage, and immunophenotyping (MARCONATO; GELAIN;COMAZZI, 2012). Considering the anatomical classification, the following lymphomas can be observed: multicentric lymphoma with generalized lymphadenopathy; mediastinal lymphoma, in which the thymus and/or mediastinal lymph nodes are affected; alimentary or gastrointestinal lymphoma; cutaneous lymphoma; and extranodal lymphoma, where non-lymphoid organs such as the brain, kidney, and eyeball are primarily affected (RODRIGUES et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Metastatic T-cell lymphoma of unknown primary origin in a dog (Canis lupus familiaris)

Rodrigues

Borges

Lima

et al. 2017

AVB

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Section: Case Reportmentioning

confidence: 71%

“…(RODRIGUES et al, 2016). Older animals, above seven years of age, constitute the most affected age group (NEUWALD et al, 2014;VILLAMIL et al, 2009).…”

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Metastatic T-cell lymphoma of unknown primary origin in a dog (Canis lupus familiaris)

Rodrigues

Borges

Lima

et al. 2017

AVB

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T-cell Lymphoma in the Nasal Cavity in Goat

Firmino

Borges

Silveira³

et al. 2023

Acta Scientiae Vet.

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Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat.Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20.Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species. Keywords: hematopoietic neoplasia, immunophenotyping, lymphocytes, dyspnea.Descritores: neoplasia hematopoietica, imunofenotipagem, linfócitos, dispneia.Título: Linfoma de células T na cavidade nasal de caprino.

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Linfoma Intranasal Em Cão: Aspectos Clínicopatológicos E Imunoistoquímicos

Cited by 2 publications

References 17 publications

Metastatic T-cell lymphoma of unknown primary origin in a dog (Canis lupus familiaris)

Metastatic T-cell lymphoma of unknown primary origin in a dog (Canis lupus familiaris)

T-cell Lymphoma in the Nasal Cavity in Goat

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