Picture fuzzy numbers (PFNs), as the generalization of fuzzy sets, are good at fully expressing decision makers’ opinions with four membership degrees. Since aggregation operators are simple but powerful tools, this study aims to explore some aggregation operators with PFNs to solve practical decision-making problems. First, new operational rules, the interaction operations of PFNs, are defined to overcome the drawbacks of existing operations. Considering that interrelationships may exist only in part of criteria, rather than all of the criteria in reality, the partitioned Heronian aggregation operator is modified with PFNs to deal with this condition. Then, desirable properties are proved and several special cases are discussed. New decision-making methods with these presented aggregation operators are suggested to process hotel selection issues. Last, their practicability and merits are certified by sensitivity analyses and comparison analyses with other existing approaches. The results indicate that our methods are feasible to address such situations where criteria interact in the same part, but are independent from each other at different parts.