Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

Kahl, Kai G.; Stapel, Britta; Frieling, Helge

doi:10.1016/j.pnpbp.2018.09.004

Cited by 36 publications

(28 citation statements)

References 216 publications

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“…Recent studies indicate a relationship between major depression and CVDs, implying that both diseases may share common physiological pathways which also include lifestyle factors such as physical activity and smoking behaviour [47]. It has been reported that most depressed patients have high rates of adverse health behaviours, including smoking [48].…”

Section: Smokingmentioning

confidence: 99%

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Sharifi‐Rad

Rodrigues

Sharopov

et al. 2020

IJERPH

189

119

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Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

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Section: Smokingmentioning

confidence: 99%

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Sharifi‐Rad

Rodrigues

Sharopov

et al. 2020

IJERPH

189

119

View full text Add to dashboard Cite

show abstract

“…Depression is the leading cause of disability worldwide and is a major contributor to the overall global burden of disease (Global Health Estimates, 2016). Its substantial socioeconomic burden is also contributed by a significantly reduced life expectancy of affected people, mainly due to suicide (Chesney, Goodwin, & Fazel, ) and comorbid medical conditions, in particular cardiovascular disorders (Kahl, Stapel, & Frieling, ; Musselman, Evans, & Nemeroff, ). The neurobiology of MDD is still not well understood, but decades of research have suggested that several neurotransmitter systems, in particular the serotonergic, dopaminergic, and adrenergic systems, are altered at different levels (aan het Rot, Mathew, & Charney, ).…”

Section: Introductionmentioning

confidence: 99%

Leukocyte telomere length is reduced in patients with major depressive disorder

Pisanu

Tsermpini

Σκώκου

et al. 2019

Drug Development Research

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Major depressive disorder (MDD) is a chronic, severe psychiatric illness with an incidence of 3% worldwide. MDD patients have a significantly impaired quality of life and reduced life expectancy compared to unaffected individuals, the latter being largely accounted for by an increased incidence of suicide and cardiovascular disorders. The premature mortality observed in MDD has been considered a signature of accelerated aging, a hypothesis supported by data showing altered functioning and morphology of several brain regions that are typically present in the aging population.

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“…Studies have found that mitochondrial dysfunction or changes in brain energy metabolism may be involved in the pathogenesis of depression [43,44]. Citrate, α-Oxoglutarate and malate are key intermediates in mitochondrial TCA cycle and all a part of the energy metabolic pathway.…”

Section: Energy Metabolismmentioning

confidence: 99%

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

et al. 2020

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Background It is known that bioenergetics of aerobic and resistance exercise are not the same but both can effectively improve depression. However, it is not clear whether and how different types of exercise can influence depression through the same metabolic regulatory system. Metabolomics provides a way to study the correlation between metabolites and changes in exercise and/or diseases through the quantitative analysis of all metabolites in the organism. The objective of this study was to investigate the effects of aerobic and resistance training on urinary metabolites by metabolomics analysis in a rodent model of depression. Methods Male Sprague-Dawley rats were given chronic unpredictable mild stress (CUMS) for eight weeks. The validity of the modeling was assessed by behavioral indices. After four weeks of CUMS, the rats that developed depression were randomly divided into a depression control group, an aerobic training group and a resistance training group. There was also a normal control group. From week 5, the rats in the exercise groups were trained for 30 min per day, five days per week, for four weeks. The urine samples were collected pre and post the training program, and analyzed by proton nuclear magnetic resonance (1 H-NMR) spectroscopy. Results Both types of training improved depression-like behavior in CUMS rats. Compared with normal control, 21 potential biomarkers were identified in the urine of CUMS rats, mainly involved in energy, amino acids and intestinal microbial metabolic pathways. Common responses to the training were found in the two exercise groups that the levels of glutamine, acetone and creatine were significantly recalled (all P<0.05) Aerobic training also resulted in changes in pyruvate and trigonelline, while resistance training modified α-Oxoglutarate, citric acid, and trimethylamine oxide (all P<0.05).

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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

Cited by 36 publications

References 216 publications

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Leukocyte telomere length is reduced in patients with major depressive disorder

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

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