Link Between Some Virulnce Factors Genes and Antibacterial Resistance of Pseudomonas Aeruginosa

Abstract

The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa. The results were revealed that only twenty one (32%) out of 65 clinical ear swabs were Pseudomonas aeruginosa. According to PCR amplification, 18 (85.7%) bacterial isolates were expressed both toxins ( exoenzyme S and exotoxin A). The data get by real time experiments were revealed that the isolates were give higher percentage of resistance were seen against Ceftazidime (90.5%) and Gentamicin (88.5%).Only thirteen isolates (61,90%) of Multidrug resistance (MDR) –Pseudomonas aeruginosa isolates were detected, and two (9.5%) isolates were resist to all 8 classes of antibiotics and considered as PDR, and three (14.2%) bacterial isolates resist seven classes of antibiotics which considered as XDR.

Studying the effect of plant extracts on gram-positive and gram-negative pathogens: Review

“…In one study, it was found that approximately (63%) of the isolates In otitis media containing multidrug-resistant Pseudomonas aeruginosa (MDR-Pseudomonas aeruginosa), two isolates (9.5%) were resistant to all eight classes of antibiotics used in the study and were considered PDR, and three bacterial isolates (14.2%) could be resistant to seven classes. of antibiotics, which were considered XDR [32] (Table 2).…”

Emergence of Multidrug Resistant Bacteria Among Patients With Respiratory Tract Infections

“…aeruginosa has been recognized as a primary opportunistic human pathogen for several decades (10) and has the potential to induce respiratory tract infections. Virulence factors and antimicrobial degrading enzymes are needed to overcome the immune system defenses resist antimicrobial treatment to initiate infection and invasion, which aids in their pathogenesis, survival, and immune system evasion (20,24). P. aeruginosa is a gram-negative bacilli that is non-spore forming, encapsulated, and usually motile due to the presence of one or two polar flagella (1,19).…”