Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11

Bale, Sherri J.; Bale, Allen E.; Stewart, Karen; Dachowski, Laura; McBride, O W; Gläser, Thomas; Green, Joseph E.; Mulvihill, John J.; Brandi, Maria Luisa; Sakaguchi, Kazushige; Aurbach, G. D.; Marx, Stephen J.

doi:10.1016/0888-7543(89)90336-4

Cited by 61 publications

(27 citation statements)

References 8 publications

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“…Over the past decade, the region 11q13 has been the focus of interest of mapping studies and linkage analysis, [29][30][31][32][33][34][35] in the search for the gene responsible for the multiple endocrine neoplasia type 1 (MEN1) syndrome. The MEN1 syndrome is an autosomal, dominantly inherited disorder characterized by the development of multiple endocrine tumors in target organs such as parathyroid, endocrine pancreas and anterior pituitary gland.…”

Section: Introductionmentioning

confidence: 99%

Allelic loss of 11q13 as detected by MEN1-FISH is not associated with mutation of the MEN1 gene in lymphoid neoplasms

et al. 1999

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Deletions and rearrangements involving the long arm of chromosome 11 are not infrequent occurrences in the non-Hodgkin's lymphomas. Recently, a tumor suppressor gene, the multiple endocrine neoplasia type 1 gene (MEN1) was cloned and mapped to chromosome 11q13. To assess the potential involvement of this gene in lymphomagenesis, we examined 94 primary cases of lymphoma and 12 cell lines by a combination of fluorescent in situ hybridization and PCR-SSCP analysis. In our initial analysis of 41 primary B or T lymphomas, MEN1 FISH analysis revealed allelic deletions in 15 cases (three of four B cell chronic lymphocytic leukemias, six of 15 follicular lymphomas, three of nine diffuse large B cell lymphomas, two of five mantle cell lymphomas, one of four Burkitt's lymphoma). To discern whether the MEN1 gene was in fact the target of the deletions, we assessed 20 of these 41 cases and an additional 74 primary lymphomas and 12 cell lines for MEN1 gene mutations using PCR-SSCP analysis. Abnormal SSCP patterns were found in exon 2 in two of the primary lymphoma cases and in one of the cell lines, but not in any of the original cases that showed MEN1 deletions by FISH. Furthermore, sequencing analysis revealed that the abnormal SSCP patterns in exon 2 were the result of a previously described genetic polymorphism (S145S: AGC → ACT), and in one sample, the result of this S145S polymorphism associated with a second nucleotide substitution at position 498 which left the encoded amino acid unchanged. Our study indicates that the 11q13 locus is a frequent target of deletion in lymphoid neoplasms, but that there are no associated mutations of the MEN1 gene. This suggests that the 11q deletions either target another gene in lymphomas, or that the MEN1 gene is inactivated through means other than mutation.

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Section: Introductionmentioning

confidence: 99%

Allelic loss of 11q13 as detected by MEN1-FISH is not associated with mutation of the MEN1 gene in lymphoid neoplasms

et al. 1999

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“…It usually entails the INT2 and HSTJ genes and also the BCLI locus, recognised as a chromosomal breakpoint in B-cell leukaemia (Tsujimoto et al, 1984), but not other genes located at the same or neighbouring bands (Ali et al, 1989). Multiple endocrine neoplasia type I (MEN-I), the pathogenesis of which seems to involve a putative FGF-member, have also been linked to a locus proximal to the INT2 gene at I Iql2-q13 (Nakamura et al, 1989;Bale et al, 1989). Consequently, although no evidence yet exists, the plain fact that both selective amplifications and non-random translocation encompass the same chromosomal region, points to its importance in the development of human cancer.…”

mentioning

confidence: 99%

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Borg

Sigurðsson²,

Clark³

et al. 1991

Br J Cancer

116

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“…This region, MEN1CR, corresponds precisely to the MEN1 region thus suggesting that a gene in llq l2 .1 2 behaves as a recessive antioncogene similar to the Rb gene. (Bale et al, 1989;Bale et al, HGM10 A2158;Thakker et al, HGM10;Larsson et al, HGM10).…”

mentioning

confidence: 99%

Report of the committee on the genetic constitution of chromosome 11

Junien¹,

McBride²

1989

Cytogenet Genome Res

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Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11

Cited by 61 publications

References 8 publications

Allelic loss of 11q13 as detected by MEN1-FISH is not associated with mutation of the MEN1 gene in lymphoid neoplasms

Allelic loss of 11q13 as detected by MEN1-FISH is not associated with mutation of the MEN1 gene in lymphoid neoplasms

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Report of the committee on the genetic constitution of chromosome 11

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