Linkage analysis of three genetic loci for disease susceptibility in Tunisian Psoriatic families

Ammar, M.; Bouchlaka-Souissi, C.; Rebaï, Ahmed; Doss, N.; Sioud, Asma; Zarâa, I.; Dhaoui, Raouf; Laamouri, R.; Osman, A. Ben; Gaaïed, Amel Ben Ammar-El; Mokni, M.

doi:10.1016/j.jdermsci.2008.12.007

Journal of Dermatological Science

2009

DOI: 10.1016/j.jdermsci.2008.12.007

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Linkage analysis of three genetic loci for disease susceptibility in Tunisian Psoriatic families

M. Ammar¹,

C. Bouchlaka-Souissi²,

Ahmed Rebaï³

et al.

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Cited by 3 publications

(3 citation statements)

References 15 publications

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confidence: 99%

“…Our group previously performed a linkage analysis of six multiplex Tunisian psoriatic families with 11 polymorphic microsatellites from the three most replicated psoriasis loci: PSORS1 (6p21), PSORS2 (17q25) 8 and PSORS4 (1q21) 9 . In that study, suggestive evidence for PSORS1 and PSORS2 was obtained 9 . In order to investigate more thoroughly the genetic susceptibility to psoriasis in the Tunisian population, we performed a genome‐wide linkage scan in four of the largest psoriatic Tunisian multiplex families described previously, 9 and three additional families.…”

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confidence: 99%

“…In that study, suggestive evidence for PSORS1 and PSORS2 was obtained 9 . In order to investigate more thoroughly the genetic susceptibility to psoriasis in the Tunisian population, we performed a genome‐wide linkage scan in four of the largest psoriatic Tunisian multiplex families described previously, 9 and three additional families. Nonparametric linkage (NPL) analyses failed to identify a single psoriasis‐linked locus that was shared among all the Tunisian families tested.…”

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confidence: 99%

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Genome-wide linkage scan for psoriasis susceptibility loci in multiplex Tunisian families

Ammar

Bouchlaka-Souissi

Helms

et al. 2013

British Journal of Dermatology

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confidence: 99%

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Genome-wide linkage scan for psoriasis susceptibility loci in multiplex Tunisian families

Ammar

Bouchlaka-Souissi

Helms

et al. 2013

British Journal of Dermatology

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Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients

et al. 2014

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A deletion of two genes from the late cornified envelope (LCE), LCE3B and LCE3C within epidermal differentiation complex on chromosome 1 was shown to be associated with both psoriasis and psoriatic arthritis (PsA) in several populations. To assess whether this deletion may contribute to the genetic predisposition to PsA in Tunisia, a total of 73 patients with PsA and 120 healthy matched controls were screened for the deletion, LCE3C_LCE3B-del, and its tag SNP, rs4112788. We also evaluated a possible relationship between PSORS1 and LCE3C_LCE3B-del through genotyping two proxy markers to HLA-C (rs12191877 and rs2073048). Our results did not provide evidence for association between the LCE3C_LCE3B-del nor the rs4112788 and the PsA. Similarly, no significant epistatic effect was observed. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. However, these results need to be confirmed by additional large-scale studies of Tunisian PsA patients and controls.

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Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families

Ammar

Bouchlaka-Souissi

Soumaya

et al. 2014

Pathologie Biologie

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Linkage analysis of three genetic loci for disease susceptibility in Tunisian Psoriatic families

Cited by 3 publications

References 15 publications

Genome-wide linkage scan for psoriasis susceptibility loci in multiplex Tunisian families

Genome-wide linkage scan for psoriasis susceptibility loci in multiplex Tunisian families

Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients

Failure to find evidence for deletion of LCE3C and LCE3B genes at PSORS4 contributing to psoriasis susceptibility in Tunisian families

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