Linkage Between Rheumatoid Arthritis Susceptibility and the Presence of HLA—DR4 and DRβ Allelic ThIrd Hypervariable Region Sequences in Southern Chinese Persons

J, Seglias; Li, Edmund K.; Cohen, M. G.; Wong, Raymond Woon Sing; Potter, Paul K.; So, Alex

doi:10.1002/art.1780350207

Cited by 29 publications

(14 citation statements)

References 11 publications

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“…In this study, we found that the most significant HLA-DRB1 allele contributing to RA susceptibility in the Chinese Shantou population was DRB1*0405, a finding that is consistent with that in previous studies of northern Chinese (Zhao et al 1996) and Singaporean Chinese with RA (Koh et al 1997), but conflicts with that in Seglias' study of southern Chinese (Seglias et al 1992). In Seglias' study, DRB1*0404 and DRB*0405 were the main DRB1*04 subtypes in the population studied, but there was no difference in the frequency of these 2 subtypes in RA patients and controls.…”

Section: Discussionsupporting

confidence: 89%

“…In all such studies, the human leukocyte antigen (HLA) region has consistently shown the strongest genetic association with RA. In particular, the association between HLA-DRB1 alleles and RA has been extensively reported in studies involving diverse ethnic groups (Sanchez et al 1990;Gao et al 1991;Boki et al 1992;Seglias et al 1992;Benazet et al1995;Zhao et al 1996;Koh et al 1997;Wakitani et al 1997;Milicic et al 2002;Kinikli et al 2003;Lee et al 2004;Ruiz-Morales et al 2004;Kapitany et al 2005).…”

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confidence: 97%

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The association of HLA-DRB1 alleles with rheumatoid arthritis in the Chinese Shantou population: a follow-up studyThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process.

Lin

Chen

Xiao

et al. 2007

Biochem. Cell Biol.

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We investigated the distribution of HLA-DRB1 alleles in a sample of the Chinese Shantou population, and explored the relationship between HLA-DRB1 alleles and the susceptibility and clinical features of rheumatoid arthritis (RA). We studied 117 consecutive patients with RA and control groups, including 38 cases of systemic lupus erythematosus and 100 healthy individuals. HLA-DRB1 genotyping was performed using PCR with sequence-specific primers. HLA-DRB1*04 subtypes were detected using spot hybridization of PCR products with sequence-specific oligonucleotide probes. We compared the frequency of HLA-DRB1 alleles in healthy control patients with that in patients with RA. Patients with RA were evaluated for sex, age at disease onset, disease duration, extra-articular involvement, presence of autoantibodies, global functional status, and radiographic damage. The frequency of HLA-DRB1*04 was found to be significantly higher in RA patients than in healthy individuals (49.6% vs 18.0%, odds ratio = 4.478, P< 0.001). HLA-DRB1*0405 was the most prominently associated subtype in RA patients (62.1% vs 27.8%, odds ratio = 4.255, P = 0.011). Compared with the HLA-DRB1*04-negative RA group, the mean duration of RA in the HLA-DRB1*04-positive RA group was longer, and the mean age at disease onset was lower. A 2-9 year follow-up study was performed, and the risk factors associated with the radiographic progression of RA were determined. Logistic regression analysis revealed that only HLA-DRB1*04 alleles were significantly associated with the radiographic progression of RA (B = 2.652, P = 0.018, Exp(B) = 14.182). Our observations indicated that the HLA-DRB1*04 alleles, especially the subtype HLA-DRB1*0405, were significantly associated with RA susceptibility in the Chinese Shantou population. The HLA-DRB1*04 alleles may be associated with the severity of RA.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 97%

The association of HLA-DRB1 alleles with rheumatoid arthritis in the Chinese Shantou population: a follow-up studyThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process.

Lin

Chen

Xiao

et al. 2007

Biochem. Cell Biol.

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“…Ever since the first description of an association between HLA-DR4 and RA in 1976 [1], several alleles of HLA-DRB1 have been associated with the predisposition to develop RA; however, the associated allele varies among different ethnic groups. For example, HLA-DRB1*0401 and 0404 are the most common found in Caucasians from North America and from Northern Europe [2,3]; while HLA-DRB1*0405 is more frequently present in Japanese [4], Chinese [5], Koreans [6], Asian Indians [7], and Caucasians from Israel [8], and Spain [9]. In addition, HLA-DRB1*1001 is observed in Spanish [9] and Asian Indians [7], while DRB1*0102 is found in Israelis [10].…”

Section: Introductionmentioning

confidence: 99%

HLA-DRB1 alleles encoding the “shared epitope” are associated with susceptibility to developing rheumatoid arthritis whereas HLA-DRB1 alleles encoding an aspartic acid at position 70 of the β-chain are protective in Mexican mestizos

et al. 2004

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“…Serological HLA-DR4 has been reported to be associated with rheumatoid arthritis (RA) in many ethnic groups [1, 2, 3, 4, 5, 6, 7, 8]. Serological HLA-DR1 [7, 9, 10, 11], DR10 [7, 12]and DR14 [13]also have been reported to be associated with RA.…”

Section: Introductionmentioning

confidence: 99%

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

Tokunaga¹,

Noda²,

Kaneoka³

et al. 1999

Nephron

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We performed serological phenotyping of HLA antigens in 175 patients with rheumatoid arthritis (RA) with (n = 41) and without (n = 134) renal involvement (RI), and DNA typing of HLA class II alleles in 75 patients. Among the patients with RA, the frequency of serologically determined HLA-DR4 was found to be significantly increased (odds ratio: 1.8, confidence interval: 1.3–2.5, p = 2.4×10^–4). In the patients without RI, the frequency of serological DR4 significantly increased (odds ratio: 2.2, confidence interval: 1.6–3.3, p = 2.6×10^–5). On the other hand, among the patients with RI, a serological determinant, DR15, did significantly increase (odds ratio: 2.7, confidence interval: 0.9–8.4, p = 1.2×10^–3) in comparison to the controls. At the DNA level, we found that the association of Japanese RA patients with serological HLA-DR4 was based on that with a genotype of HLA-DRB1*0405 (odds ratio: 2.4, confidence interval: 1.5–4.0, p = 4.4×10^–4) and also found an association of HLA-DRB1*1501 (odds ratio: 2.8, confidence interval: 1.2–6.6, p = 0.017) with RA patients having RI. Our results confirmed the association of HLA-DRB1*04 with RA over the ethnic barrier at the DNA level. Our results also suggested a distinct genetic effect of HLA-DRB1*1501 in the aspect of the susceptibility of RI in RA.

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Linkage Between Rheumatoid Arthritis Susceptibility and the Presence of HLA—DR4 and DRβ Allelic ThIrd Hypervariable Region Sequences in Southern Chinese Persons

Cited by 29 publications

References 11 publications

HLA-DRB1 alleles encoding the “shared epitope” are associated with susceptibility to developing rheumatoid arthritis whereas HLA-DRB1 alleles encoding an aspartic acid at position 70 of the β-chain are protective in Mexican mestizos

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

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