Linkage disequilibria between HLA‐B, C1_4_1, MICA and MICB

Glas, J.; Werner, A.; Brünnler, Günter; Witter, K.; Scholz, Siegfried; Weiss, E.H.; Albert, E. D.

doi:10.1034/j.1399-0039.2001.580611.x

Cited by 14 publications

(20 citation statements)

References 32 publications

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“…The present data indicate that some structurally related alleles (B*45, B*5001, B5002) had the same association with MICA*00902 (Table 2), whereas MICA-B associations were in some cases different among alleles belonging to serologically related (cross-reactive) groups, such as B*49 and B*50 (B21 group, MICA*004-B*4901 and MICA*00902-B*50 associations), and B*45 and B*44 (B12 group, MICA*00902-B*4501, MICA*004-B*440301, MICA*00801-B*4402); this confirms the observation that sometimes a common evolutionary origin could be more related to the primary structure of alleles than to serologic similarities [29,30].…”

Section: Discussionsupporting

confidence: 85%

MICA Polymorphism in a Population From North Morocco, Metalsa Berbers, Using Sequence-Based Typing

et al. 2005

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Section: Discussionsupporting

confidence: 85%

MICA Polymorphism in a Population From North Morocco, Metalsa Berbers, Using Sequence-Based Typing

et al. 2005

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“…Common strong linkage disequilibrium haplotypes about MICB–HLA‐B and MICA–MICB are obviously different among the German population (10) and the Guangzhou Han population. However, this is true for HLA‐B*38 associated with MICA A9, B*51 and B*44 associated with A6, HLA‐B*13 associated with A5.1 and HLA‐B*15(62) associated with A5 in the two populations.…”

Section: Frequency Distribution Of Alleles At Mica and Micb Microsamentioning

confidence: 98%

“…MICB CA14 is a very common allele in the Guangzhou Han population, as well as in the Japanese (6) and German (10) populations, and its frequency in the Guangzhou Han population reaches as high as 0.3255. MICB CA24, which occurs at low frequencies in the Guangzhou Han and Japanese populations, occurs at a high frequency in the German population (10.95%).…”

Section: Frequency Distribution Of Alleles At Mica and Micb Microsamentioning

confidence: 99%

Study on the haplotypes of MICA and MICB microsatellite and HLA‐B locus in the Guangzhou Han population

et al. 2004

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The purpose of this study was to investigate the genetic polymorphisms and haplotypes of microsatellite locus in exon 5 of the MICA gene and intron 1 of the MICB gene and human leukocyte antigen-B (HLA-B) gene based on 106 samples of the Guangzhou Han population through means of polymerase chain reaction and the fluorescent technique (6-FAM). The corresponding haplotype frequencies, linkage disequilibrium values and relative linkage disequilibrium values were estimated based on population data. The results show that the genotype distributions of MICA and MICB microsatellite and HLA-B satisfy the Hardy-Weinberg equilibrium. In total, five alleles of MICA microsatellite locus and 14 alleles of MICB microsatellite locus were observed. MICA A5 was the most common allele (0.2877), whereas A4 was the least common (0.1321). MICB CA14 was the most common allele (0.3255), and CA19 and CA28 were the two least common (0.0047). CA27 was not observed at all. Five kinds of MICA-MICB haplotypes, 18 kinds of MICA-HLA-B haplotypes and 12 kinds of MICB-HLA-B haplotypes occurred at frequencies of more than 1%. The common haplotypes of MICA-MICB, MICA-HLA-B and MICB-HLA-B were A5-CA14, A5.1-CA18, A4-CA26, A9-CA15, A5-B*15(62), A5.1-B*1301/1302, A4-B*1301/1302, A6-B*51, A6-B*4403, A9-B*3802, CA14-B*4601, CA18-B*1301/1302 and CA26-B*1301/1302, and these haplotypes showed strong linkage disequilibrium. The polymorphisms and haplotype distributions of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population have their own distinct genetic characteristics. The microsatellite locus of exon 5 of the MICA gene and intron 1 of the MICB gene could therefore be used as genetic markers in the studies of anthropology, gene linkage analysis in genetic diseases, individual identification and paternity testing in forensic medicine.

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“…This haplotype is also present among Basque DM1 patients and represents the highly conserved B8‐DRB1*03‐DQ2 Caucasian haplotype, associated with a number of other autoimmune disorders (22, 28). There are only 46 kb between HLA‐B and MICA and the effect of linkage disequilibrium is particularly strong, with allele A4 being very strongly associated with HLA‐B18 and allele A5.1 with B7 (as part of the protective extended haplotype B7‐DRB1*1501‐DQB1*0602) and B8 (in the risk haplotype mentioned earlier) (24, 31). Nevertheless, no association of allele A5.1 was observed after stratification for HLA‐DR3 and, in fact, the OR obtained (Table 5) would suggest a ‘protective’ effect of the allele.…”

Section: Allelic Distribution Of the Mica Alleles Among The Basquesmentioning

confidence: 99%

HLA‐DRB1 and MHC class 1 chain‐related A haplotypes in Basque families with celiac disease

et al. 2002

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The contribution of HLA genes to the genetic risk for celiac disease (CD) has been known for a long time. Recent publications have pointed to the possibility that a second, independent susceptibility locus could be located in the same genomic region, and a triplet repeat polymorphism in exon 5 of the gene MHC class I chain-related protein A (MICA; located between TNFA and HLA-B) has been associated with several autoimmune disorders, including type 1 diabetes mellitus (DM1) and Addison's disease. On the other hand, a single amino acid change in exon 3 of MICA (M129V) has been shown to strongly reduce MICA binding to NKG2D, an activating natural killer receptor expressed also on T cells, and this could have significant effects on autoimmune reactions. In this study, we have analyzed the contribution of these polymorphisms to CD in 37 Basque families, and have constructed MICA-HLA-DRB1 haplotypes to determine whether MICA has an effect independent from the HLA class II conferred risk. In our population, HLA-DRB1*0301 was associated with an increased risk for CD, while HLA-DRB1*1501 conferred protection from the disease (OR: 7.38 and 0.06, respectively). On the other hand, MICA allele A4 was positively associated with the disease (OR: 4.69) whereas allele A9 showed a trend towards protection (OR: 0.18), although significance did not hold after correction. No association of the exon 3 biallelic polymorphism was observed. A positive allelic association was found for haplotypes A5.1-DRB1*0301 (associated with risk for disease), A4-DRB1*0301 and A6-DRB1*07. In view of our results, both HLA-DRB1 and MICA are associated with CD, but stratification analysis did not show any independent contribution of the MICA polymorphisms analyzed to CD risk. Besides, MICA allele A4 (also A5.1 was associated with risk for CD and other diseases) is in strong linkage disequilibrium with HLA-DRB1*0301. Finally, the major histocompatibility complex region's conferred susceptibility to CD, at least in Basque, is very similar to that observed for DM1, with shared risk and protective haplotypes.

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Linkage disequilibria between HLA‐B, C1_4_1, MICA and MICB

Cited by 14 publications

References 32 publications

MICA Polymorphism in a Population From North Morocco, Metalsa Berbers, Using Sequence-Based Typing

MICA Polymorphism in a Population From North Morocco, Metalsa Berbers, Using Sequence-Based Typing

Study on the haplotypes of MICA and MICB microsatellite and HLA‐B locus in the Guangzhou Han population

HLA‐DRB1 and MHC class 1 chain‐related A haplotypes in Basque families with celiac disease

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