Linkage of AIDS and cancer registries in Italy

Franceschi, Silvia; Maso, Luigino Dal; Arniani, Stefania; Re, A. Lo; Barchielli, Alessandro; Milandri, Carlo; Simonato, Lorenzo; Vercelli, Marina; Zanetti, Roberto; Rezza, Giovanni

doi:10.1002/(sici)1097-0215(19980316)75:6<831::aid-ijc3>3.0.co;2-w

Cited by 13 publications

(16 citation statements)

References 15 publications

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“…However, the completeness of RAIDS and Italian CRs had been shown to be satisfactory and the linkage procedures we used had been validated (Conti et al, 1997;AjdacicGross et al, 2001;Dal Maso et al, 2001a). The problem of migration of PWHA out of CR areas should be less severe in Italy than elsewhere, as population mobility is comparatively low and HIV and cancer treatments are available free of charge in all Italian regions (Franceschi et al, 1998b). As already reported (Biggar et al, 1996), SIRs for all cancer sites or types are exaggerated in the …”

Section: Risk Of Cancer In Persons With Aids In Italymentioning

confidence: 78%

“…Since a large number of NADCs occurs before AIDS, the major strength of such methodology is represented by the access to a large number of person-years of observation both before and after AIDS (Franceschi et al, 1998b;Goedert et al, 1998). The number of PWHA and of cancer diagnoses may be underestimated on account of incompleteness of reporting to either AIDS or CRs or of missed linkages.…”

Section: Risk Of Cancer In Persons With Aids In Italymentioning

confidence: 99%

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Risk of cancer in persons with AIDS in Italy, 1985–1998

et al. 2003

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A record linkage was carried out between the Italian Registry of AIDS and 19 Cancer Registries (CRs), which covered 23% of the Italian population, to estimate the overall cancer burden among persons with HIV or AIDS (PWHA) in Italy, according to various characteristics. Observed and expected numbers of cancer and standardised incidence ratios (SIRs) were assessed until 1998 in 12 104 PWHA aged 15 -69 years, for a total of 60 421 person-years. Significantly increased SIRs were observed for Kaposi's sarcoma (KS, 1749-fold higher than the general population), non-Hodgkin's lymphomas (NHL, 352), and invasive cervical cancer (22). SIR was significantly elevated also for cancer of the anus (34), lung cancer (2.4), brain tumours (4.4), Hodgkin's disease (16), and leukaemias (5.3). The majority of lung and brain cancers were not histologically confirmed, and the possibility of misclassification with KS or NHL cannot be ruled out. The SIR for all non-AIDS-defining cancers was 2.2 in men and 2.5 in women. Intravenous drug users showed significantly more elevated SIRs for lung cancer (9.4), and brain tumours (6.7) than other transmission categories (SIR ¼ 1.4 and 2.3, respectively). This study confirmed increased SIRs for haemolymphopoietic neoplasms other than NHL in PWHA, although manyfold smaller than for NHL. An association with human papillomavirus-related cancers was also confirmed.

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Section: Risk Of Cancer In Persons With Aids In Italymentioning

confidence: 78%

Section: Risk Of Cancer In Persons With Aids In Italymentioning

confidence: 99%

Risk of cancer in persons with AIDS in Italy, 1985–1998

et al. 2003

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“…HIV infection has also been associated with cervical cancer risk [2], which seems to vary according to co-infection with different HPV types [3,4]. The association between HIV and cervical cancer appears to be less evident in low-income countries, notably sub-Saharan Africa, than in high-income countries [5,6]. Two studies conducted at the beginning of the AIDS epidemic in Uganda [7] and Tanzania [8], which assessed HIV infection and cervical cancer, showed no association.…”

Section: Introductionmentioning

confidence: 99%

“…Two studies conducted at the beginning of the AIDS epidemic in Uganda [7] and Tanzania [8], which assessed HIV infection and cervical cancer, showed no association. However, a positive association has been observed in Western countries such as Italy, France and Spain [5,9,10], as well as in some recent studies from Uganda [11] and Tanzania [12]. Whether these differences in cervical cancer risk between studies can be explained by differences in co-infection with specific HPV types remains unclear.…”

Section: Introductionmentioning

confidence: 99%

HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

Odida

Sandin

Mirembe

et al. 2011

Infect Agents Cancer

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BackgroundWhile the association of human papillomavirus (HPV) with cervical cancer is well established, the influence of HIV on the risk of this disease in sub-Saharan Africa remains unclear. To assess the risk of invasive cervical carcinoma (ICC) associated with HIV and HPV types, a hospital-based case-control study was performed between September 2004 and December 2006 in Kampala, Uganda. Incident cases of histologically-confirmed ICC (N=316) and control women (N=314), who were visitors or care-takers of ICC cases in the hospital, were recruited. Blood samples were obtained for HIV serology and CD4 count, as well as cervical samples for HPV testing. HPV DNA detection and genotyping was performed using the SPF10/DEIA/LiPA25 technique which detects all mucosal HPV types by DEIA and identifies 25 HPV genotypes by LiPA version 1. Samples that tested positive but could not be genotyped were designated HPVX. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression, adjusting for possible confounding factors. ResultsFor both squamous cell carcinoma (SCC) and adenocarcinoma of the cervix, statistically significantly increased ORs were found among women infected with HPV, in particular single HPV infections, infections with HPV16-related types and high-risk HPV types, in particular HPV16, 18 and 45. For other HPV types the ORs for both SCC and adenocarcinoma were not statistically significantly elevated. HIV infection and CD4 count were not associated with SCC or adenocarcinoma risk in our study population. Among women infected with high-risk HPV types, no association between HIV and SCC emerged. However, an inverse association with adenocarcinoma was observed, while decrease in CD4 count was not associated with ICC risk.ConclusionsThe ORs for SCC and adenocarcinoma were increased in women infected with HPV, in particular single HPV infections, infections with HPV16- and 18-related types, and high-risk HPV types, specifically HPV16, 18 and 45. HIV infection and CD4 count were not associated with SCC or adenocarcinoma risk, but among women infected with high-risk HPV types there was an inverse association between HIV infection and adenocarcinoma risk. These results suggest that HIV and CD4 count may have no role in the progression of cervical cancer.

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“…Clinical series and cohort studies have provided data on the frequency and characteristics of NHL in HIV‐positive individuals 5, 7, 8. Since the mid‐1990s, a few epidemiological linkage studies on AIDS and cancer registries9–12 have also contributed to a better quantification of the burden of NHL in HIV‐infected populations.…”

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confidence: 99%

Non-Hodgkin lymphoma among young adults with and without AIDS in Italy

et al. 2001

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To compare the presentation and prognosis of non‐Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records from 13 cancer registries (CR), covering about 15% of the Italian population. During the period 1985–94, among PWA ages 15–49, 136 NHLs were identified (8% of all NHLs) and were compared with 1,481 concurrent incident NHL cases of the same age group among non‐PWA. Percentages above 13% of all NHLs were registered in the northern areas of Genoa and Varese, i.e., the most heavily affected by the AIDS epidemic. Between 1 year prior to and 3.5 years after AIDS diagnosis, PWA showed an overall standardised incidence ratio (SIR) for NHL of 302. SIR was particularly high (394) within 3 months after AIDS diagnosis and subsequently declined to 170. SIR was somewhat higher in females (428) than in males (280) but similar among intravenous‐drug users (299) and other HIV‐transmission groups (309). High‐grade NHL, particularly immunoblastic and Burkitt's lymphoma, were twice as frequent among PWA than non‐PWA. Conversely, low‐grade NHL were less frequent. Except for the high proportion of brain localisation, no clear difference emerged in the pattern of NHL presentation site in PWA compared with non‐PWA. At variance with NHL in the general population, among PWA histological grade had little impact on survival, which overall appeared to be very poor (2‐year survival: 10%; 95% confidence interval: 3%–17%). Our present linkage of RAIDS and CRs represents an efficient tool for the surveillance of trends in incidence and survival of NHL among PWA in Italy. © 2001 Wiley‐Liss, Inc.

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Linkage of AIDS and cancer registries in Italy

Cited by 13 publications

References 15 publications

Risk of cancer in persons with AIDS in Italy, 1985–1998

Risk of cancer in persons with AIDS in Italy, 1985–1998

HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda: a case-control study

Non-Hodgkin lymphoma among young adults with and without AIDS in Italy

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