Linkage of the canine-derived microsatellites in the red fox (Vulpes vulpes) and arctic fox (Alopex lagopus) genomes

Klukowska, J.; Szydłowski, M.; Świtoński, M.

doi:10.1034/j.1601-5223.2002.01679.x

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…These observations were recently confirmed by Kukekova et al [2009]. The first step towards developing linkage maps of foxes was made by Klukowska et al [2002]. Using 19 caninederived microsatellites, 2 linkage groups in the red fox and 4 linkage groups in the arctic fox have been identified.…”

Section: Cytogenetic Genome Marker Mapsmentioning

confidence: 57%

Comparative Genomics of 3 Farm Canids in Relation to the Dog

Świtoński¹,

Szczerbal²,

Nowacka‐Woszuk³

2009

Cytogenet Genome Res

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There are 3 canids besides the dog (Canis familiaris): the red fox (Vulpes vulpes), arctic fox (Alopex lagopus) and Chinese raccoon dog (Nyctereutes procyonoides procyonoides), which have been extensively studied with the use of cytogenetic and molecular genetics techniques. These 3 species are considered as farm fur-bearing animals. In addition, they are also useful models in comparative genomic studies of the canids. In this review genome organization, karyotype evolution, comparative marker maps, DNA polymorphism and similarity of selected gene sequences of the 3 farm species are discussed in relation to the dog. Also the nature and variability of the B chromosomes, present in the red fox and the Chinese raccoon dog, were considered. These comparative analyses showed that among the studied canids the Chinese raccoon dog is phylogenetically the closest species to the dog. On the other hand, the most advanced linkage and cytogenetic marker maps of the red fox genome facilitate genome scanning studies with the aim to search for chromosome locations of QTL regions for behavior and production traits.

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Section: Cytogenetic Genome Marker Mapsmentioning

confidence: 57%

Comparative Genomics of 3 Farm Canids in Relation to the Dog

Świtoński¹,

Szczerbal²,

Nowacka‐Woszuk³

2009

Cytogenet Genome Res

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“…The most important fur coat traits are: animal size, pelt size, fur coat quality, and colour type (Filistowicz et al 1999). An analysis of the genetic background underlying these traits is hampered by poor information on the arctic fox genome, including the polymorphism and localisation of molecular markers and functional genes (Klukowska et al 2002;Rogalska-Ni¿nik et al 2003;Szczerbal et al 2003aSzczerbal et al , 2003bSwitonski et al 2003). Only very recently Keski-Nisula et al (2005) identified the first linkage groups in this species.…”

Section: Introductionmentioning

confidence: 99%

Statistical aspects of genetic association testing in small samples, based on selective DNA pooling data in the arctic fox

Szyda

Liu²,

Zatoń-Dobrowolska

et al. 2008

J Appl Genet

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We analysed data from a selective DNA pooling experiment with 130 individuals of the arctic fox (Alopex lagopus), which originated from 2 different types regarding body size. The association between alleles of 6 selected unlinked molecular markers and body size was tested by using univariate and multinomial logistic regression models, applying odds ratio and test statistics from the power divergence family. Due to the small sample size and the resulting sparseness of the data table, in hypothesis testing we could not rely on the asymptotic distributions of the tests. Instead, we tried to account for data sparseness by (i) modifying confidence intervals of odds ratio; (ii) using a normal approximation of the asymptotic distribution of the power divergence tests with different approaches for calculating moments of the statistics; and (iii) assessing P values empirically, based on bootstrap samples. As a result, a significant association was observed for 3 markers. Furthermore, we used simulations to assess the validity of the normal approximation of the asymptotic distribution of the test statistics under the conditions of small and sparse samples.

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“…Comparative chromosome painting of the arctic fox and the red fox chromosomes with the use of the dog whole chromosome painting probes revealed homologous chromosome segments in the karyotypes of these species ( Graphodatsky et al 2000). Recently, an attempt to construct linkage map of both genomes was also undertaken ( Klukowska et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite polymorphism and genetic distances between the dog, red fox and arctic fox

Klukowska¹,

Strabel²,

Mackowski³

et al. 2003

J Animal Breeding Genetics

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Summary This study compared polymorphism of nine canine‐derived microsatellites (MS) (CPH1, CPH3, CPH6, CPH11, 2004, 2010, 2140, 2168 and 2319) in three species of the family Canidae. The DNA samples of 151 dogs, 53 arctic foxes and 91 red foxes were examined. The canine‐derived primers did not amplify two MS (CPH1 and CPH11) in genome samples of the arctic fox. The most polymorphic MS in the studied species was the one named 2319. For majority of the loci mean allele size was higher in the dog than in two fox species. The genetic distances between the species were estimated using three formulas: DS, Da and (σμ)2. The estimated distances between both fox species were the smallest, while those between the dog and the arctic fox were the largest.

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Linkage of the canine-derived microsatellites in the red fox (Vulpes vulpes) and arctic fox (Alopex lagopus) genomes

Cited by 8 publications

References 9 publications

Comparative Genomics of 3 Farm Canids in Relation to the Dog

Comparative Genomics of 3 Farm Canids in Relation to the Dog

Statistical aspects of genetic association testing in small samples, based on selective DNA pooling data in the arctic fox

Microsatellite polymorphism and genetic distances between the dog, red fox and arctic fox

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