Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

McCabe, Ciara

doi:10.1016/j.cobeha.2018.07.001

Cited by 21 publications

(31 citation statements)

References 97 publications

(109 reference statements)

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“…However, most studies assess anhedonia using only a few questions within other questionnaires such as the Beck Depression Inventory and do not provide a comprehensive understanding of the experience of anhedonia on a dimensional scale. 9 Therefore we suggest using assessments such as the Temporal Experience of Pleasure Scales (TEPS) that allow for the separate components of anhedonia (anticipation and consummation) to be measured. 9,10 Neurobiological studies have found blunted neural reward responses that relate to positive affect 11 and depression symptoms in adolescents 12,13 and even young children.…”

Section: Anhedonia Assessmentmentioning

confidence: 99%

“…9 Therefore we suggest using assessments such as the Temporal Experience of Pleasure Scales (TEPS) that allow for the separate components of anhedonia (anticipation and consummation) to be measured. 9,10 Neurobiological studies have found blunted neural reward responses that relate to positive affect 11 and depression symptoms in adolescents 12,13 and even young children. 14 However, most neurobiological tasks of reward do not examine the different phases of processing such as the anticipatory, motivational and consummatory aspects.…”

Section: Anhedonia Assessmentmentioning

confidence: 99%

Section: Anhedonia Assessmentmentioning

confidence: 99%

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Dimensional anhedonia and the adolescent brain: reward and aversion anticipation, effort and consummation

Rzepa

McCabe

2019

BJPsych open

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Background Given the heterogeneity of depression the Research Domain Criteria Framework suggests a dimensional approach to understanding the nature of mental illness. Neural reward function has been suggested as underpinning the symptom of anhedonia in depression but how anhedonia is related to aversion processing is unclear. Aims To assess how the dimensional experience of anhedonia and depression severity relate to reward and aversion processing in the human brain. Method We examined adolescents and emerging adults (n = 84) in the age range 13–21 years. Using a dimensional approach we examined how anhedonia and depression related to physical effort to gain reward or avoid aversion and neural activity during the anticipation, motivation/effort and consummation of reward and aversion. Results As anhedonia increased physical effort to gain reward decreased. As anhedonia increased neural activity decreased during effort to avoid in the precuneus and insula (trend) and increased in the caudate during aversive consummation. We found participants with depression symptoms invested less physical effort than controls and had blunted neural anticipation of reward and aversion in the precuneus, insula and prefrontal cortex and blunted neural activity during effort for reward in the putamen. Conclusions We show for the first time that both physical effort and neural activity during effort correlate with anhedonia in adolescents and that amotivation might be a specific deficit of anhedonia irrespective of valence. Future work will assess if these neural mechanisms can be used to predict blunted approach and avoidance in adolescents at risk of depression.

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Section: Anhedonia Assessmentmentioning

confidence: 99%

Section: Anhedonia Assessmentmentioning

confidence: 99%

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Dimensional anhedonia and the adolescent brain: reward and aversion anticipation, effort and consummation

Rzepa

McCabe

2019

BJPsych open

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“…However, as with adult depression described above, there is a heterogeneity in symptoms of adolescent depression and it is not entirely clear how they map to neurobiology [6]. One reason for this has been inconsistent use of questionnaires and assessments in research, which lack any specific detail about mood change in depression [7]. Understanding adolescent depression could benefit from more detailed measures of specific symptoms, e.g., anhedonia (the reduced experience of interest and pleasure), which is currently usually only assessed via its presence or absence and not in any detail from the adolescent experience [7].…”

Section: Adolescent Depressionmentioning

confidence: 99%

What Role Does the Prefrontal Cortex Play in the Processing of Negative and Positive Stimuli in Adolescent Depression?

Kaya

McCabe

2019

Brain Sciences

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This perspective describes the contribution of the prefrontal cortex to the symptoms of depression in adolescents and specifically the processing of positive and negative information. We also discuss how the prefrontal cortex (PFC) activity and connectivity during tasks and at rest might be a biomarker for risk for depression onset in adolescents. We include some of our recent work examining not only the anticipation and consummation of positive and negative stimuli, but also effort to gain positive and avoid negative stimuli in adolescents with depression. We find, using region of interest analyses, that the PFC is blunted in those with depression compared to controls across the different phases but in a larger sample the PFC is blunted in the anticipatory phase of the study only. Taken together, in adolescents with depression there is evidence for dysfunctional PFC activity across different studies and tasks. However, the data are limited with small sample sizes and inconsistent findings. Larger longitudinal studies with more detailed assessments of symptoms across the spectrum are needed to further evaluate the role of the PFC in adolescent depression.

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“…Of particular interest, structural alteration (e.g., volumetric changes) in subcortical regions including the amygdala, hippocampus, and NAcc has been known to be associated with both social stress and psychopathology 9,10 . This may be because these regions have been implicated in social and emotion processing and reward-punishment processing 11,12 . These regions are also known to be sensitive to social stress 13 , and continue to develop throughout the adolescence 14 .…”

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confidence: 99%

The indirect effect of peer problems on adolescent depression through nucleus accumbens volume alteration

Lee

Yoo

Lee

et al. 2020

Sci Rep

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Literature suggests that neurobiological factors such as brain structure play an important role in linking social stress with depression in adolescence. We aimed to examine the role of subcortical volumetric alteration in the association between peer problems as one type of social stress and adolescent depression. We hypothesized that there would be indirect effects of peer problems on adolescent depression through subcortical volumetric alteration. Seventy eight adolescents with major depressive disorder (MDD) (age mean [SD] = 14.9 ± 1.5, 56 girls) and 47 healthy controls [14.3 ± 1.4, 26 girls]) participated in this study. High-resolution structural T1 images were collected using the Siemens 3T MR scanner. Subcortical volumes were segmented using the Freesurfer 6.0 package. Peer problems were assessed using the Peer-Victimization Scale and the Bullying-Behavior Scale. There was a significant indirect effect of peer problems on adolescent depression through nucleus accumbens (NAcc) volume alteration, but not through the amygdala and hippocampal volumes. This result supported our model, which stated that peer problems have indirect effects through subcortical volumetric alteration (i.e., increased NAcc volume) on adolescent depression. Our finding suggests that altered NAcc volume may serve as a pathway, through which peer problems as one type of social stressor contribute to adolescent depression. Adolescents experience peer problems (e.g., involvement in bully-victim problems) as they devote more time and effort to peer relationships 1. The mean prevalence rates of traditional bullying and cyberbullying involvement were approximately 35% and 15% across 80 studies 2. These peer problems such as being a bully and a victim are considered to be major social stressors, which are known to be related to important adolescent public health issues 3. For example, youth who were bullies and victims showed higher rates of concurrent depression 3 and reported to having long-term adverse effects with greater rates of adulthood depression and suicidality 4. A recent study showed that the prevalence rates of both peer problems and depression remained high in 2015, or even increased compared to those in 2005 5 , indicating that the associations between peer problems and adolescent depression may continue to affect significant public health problems. To ameliorate such public health problems associated with peer relational problems and adolescent depression, other factors should be considered. It has been suggested that neurobiological factors (e.g., brain structure and function) 6 may play an important role in linking social stress with adolescent depression. Furthermore, adolescence is a developmental period for remodeling brain structures and increasing neural plasticity in response to social stress 7. Brain structure may dramatically change in order to adapt to different social and emotional stresses (e.g., problematic peer relations such as bullying involvement) that frequently occur during adolescence. Brain structure alter...

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Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

Cited by 21 publications

References 97 publications

Dimensional anhedonia and the adolescent brain: reward and aversion anticipation, effort and consummation

Dimensional anhedonia and the adolescent brain: reward and aversion anticipation, effort and consummation

What Role Does the Prefrontal Cortex Play in the Processing of Negative and Positive Stimuli in Adolescent Depression?

The indirect effect of peer problems on adolescent depression through nucleus accumbens volume alteration

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