Linking COVID-19, monocyte activation and sepsis: MDW, a novel biomarker from cytometry

Riva, Giovanni; Nasillo, Vincenzo; Luppi, Mario; Tagliafico, Enrico; Trenti, Tommaso

doi:10.1016/j.ebiom.2021.103754

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…Beside hemorheological assessment, other cell-based prognostic markers are under examination or already established in COVID-19 inflammation monitoring. Both increased monocyte distribution width (MDW) [ 72 , 73 ] and higher neutrophil-to-lymphocyte ratios (NLR) [ 74 , 75 ] predicted severity and mortality in COVID-19 patients and can easily be obtained during hematological measurements. Thus, for the evaluation of the severity of the disease, it would be useful to use both cell-based systems markers as a combined approach, as there are many indications that both systems are influenced by SARS-CoV2 and that different results regarding the markers can be expected in different phases of the disease.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients

Bizjak

John

Matits

et al. 2022

IJMS

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Hematological and hemorheological parameters are known to be altered in COVID-19; however, the value of combined monitoring in order to deduce disease severity is only scarcely examined. A total of 44 acute SARS-CoV-2-infected patients (aCOV) and 44 age-matched healthy controls (Con) were included. Blood of aCOV was sampled at admission (T0), and at day 2 (T2), day 5 (T5), day 10 (T10), and day 30 (T30) while blood of Con was only sampled once. Inter- and intra-group differences were calculated for hematological and hemorheological parameters. Except for mean cellular volume and mean cellular hemoglobin, all blood cell parameters were significantly different between aCOV and Con. During the acute disease state (T0–T5), hematological and hemorheological parameters were highly altered in aCOV; in particular, anemic conditions and increased immune cell response/inflammation, oxidative/nitrosative stress, decreased deformability, as well as increased aggregation, were observed. During treatment and convalescence until T30, almost all abnormal values of aCOV improved towards Con values. During the acute state of the COVID-19 disease, the hematological, as well as the hemorheological system, show fast and potentially pathological changes that might contribute to the progression of the disease, but changes appear to be largely reversible after four weeks. Measuring RBC deformability and aggregation, as well as oxidative stress induction, may be helpful in monitoring critically ill COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients

Bizjak

John

Matits

et al. 2022

IJMS

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“…Combined multi‐omics analysis could better analyze the systemic responses as well as local tissue‐specific responses to sepsis 15 . In addition, some other biomarkers, such as cell‐free DNA and monocyte activation are emerging as sepsis biomarkers 16,17 . The application of machine learning in studying sepsis biomarkers and the establishment of a model in assessing the risk of death from septic shock could also help to promote the finding of novel biomarkers for sepsis diagnosis and prognosis.…”

Section: Introductionmentioning

confidence: 99%

“… 15 In addition, some other biomarkers, such as cell‐free DNA and monocyte activation are emerging as sepsis biomarkers. 16 , 17 The application of machine learning in studying sepsis biomarkers and the establishment of a model in assessing the risk of death from septic shock could also help to promote the finding of novel biomarkers for sepsis diagnosis and prognosis. Several studies have previously summarized the progress of research on sepsis markers in children.…”

Section: Introductionmentioning

confidence: 99%

Multilevel omics for the discovery of biomarkers in pediatric sepsis

Wang,

Li,

Qian

et al. 2023

Pediatric Investigation

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Severe sepsis causes organ dysfunction and continues to be the leading reason for pediatric death worldwide. Early recognition of sepsis could substantially promote precision treatment and reduce the risk of pediatric death. The host cellular response to infection during sepsis between adults and pediatrics could be significantly different. A growing body of studies focused on finding markers in pediatric sepsis in recent years using multi‐omics approaches. This narrative review summarized the progress in studying pediatric sepsis biomarkers from genome, transcript, protein, and metabolite levels according to the omics technique that has been applied for biomarker screening. It is most likely not a single biomarker could work for precision diagnosis of sepsis, but a panel of markers and probably a combination of markers detected at multi‐levels. Importantly, we emphasize the importance of group distinction of infectious agents in sepsis patients for biomarker identification, because the host response to infection of bacteria, virus, or fungus could be substantially different and thus the results of biomarker screening. Further studies on the investigation of sepsis biomarkers that were caused by a specific group of infectious agents should be encouraged in the future, which will better improve the clinical execution of personalized medicine for pediatric sepsis.

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“…Previous studies pointed to many clinical [ 10 ] and paraclinical [ 11 ] findings as possible risk factors for deterioration of patient or death. For example, in an Italian study of 87 patients with COVID-19, a high Monocyte Distribution Width (MDW) value emerged as the prognostic factor of fatal outcome with sensitivity 0.75 and specificity 0.70 [ 12 ] that reflected hyperinflammation mediated by monocyte/macrophage subsets [ 13 , 14 , 15 , 16 ]. In another study, the presence of neurological symptoms that were associated with a poorer prognosis was predicted by low lymphocyte count and increased lactate dehydrogenase and interleukin-6 [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

et al. 2022

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We aimed to search whether neurological symptoms or signs (NSS) and the MEWS (Modified Early Warning Score) score were associated with in-hospital mortality or oxygen requirement during the first 14 days of hospitalization in COVID-19 patients recruited at the University Hospital in Krakow, Poland. The detailed clinical questionnaires on twenty NSS were either filled out by patients prospectively or retrospectively assessed by neurologists based on daily medical records. NSS were considered high or low-risk if they were associated with increased or decreased mortality in the univariable analysis. This cohort study included 349 patients with COVID-19 (median age 64, interquartile range (51–77), women 54.72%). The presence of high-risk NSS (decreased level of consciousness, delirium, seizures, and symptoms of stroke or transient ischemic attack) or its combination with the absence of low-risk NSS (headache, dizziness, decreased mood, and fatigue) increased the risk of in-hospital mortality in SARS-CoV-2 infection 3.13 and 7.67-fold, respectively. The presence of low-risk NSS decreased the risk of in-hospital mortality in COVID-19 patients more than 6-fold. Death in patients with SARS-CoV-2 infection, apart from NSS, was predicted by older age, neoplasm, and higher MEWS scores on admission. High-risk NSS or their combination with the absence of low-risk NSS increased the risk of oxygen requirement during hospitalization in COVID-19 patients 4.48 and 1.86-fold, respectively. Independent predictors of oxygen therapy during hospitalization in patients with SARS-CoV-2 infection were also older age, male sex, neoplasm, and higher MEWS score on admission.

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Linking COVID-19, monocyte activation and sepsis: MDW, a novel biomarker from cytometry

Cited by 12 publications

References 5 publications

SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients

SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients

Multilevel omics for the discovery of biomarkers in pediatric sepsis

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

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