As weather and climate extremes continue to set new records (WMO, 2017), it is becoming increasingly important to study the effects of these extremes on hydrologic cycles (Bates et al., 2008) as well as our ability to simulate these changes within hydrologic models (Nijssen et al., 2001; Xu, 1999). In the United States, Cal-Abstract Climate change impacts on hydroclimatology are becoming increasingly apparent around the world. It is unknown how annual variations in precipitation and air temperature alter the modelinferred importance of hydrological processes and how this varies across watersheds. To examine this, we used parsimonious rainfall-runoff model and applied time-varying sensitivity analysis across 30 Californian watersheds for a 33-year period (1981-2014). We calculated annual total order sensitivity indices for five performance metrics: Kling-Gupta Efficiency (KGE) and model error in simulating hydrologic signatures (runoff ratio, slope of flow duration curve, baseflow index, and timing of streamflow centroid). Sensitivity of hydrological signatures to the parameters differed by signature, while parameter importance with respect to KGE was much more spatially and temporally variable. Variations in parameter sensitivity with respect to KGE were either correlated with air temperature (snow-dominated sites in the Sierra Nevada) or precipitation (lower elevation sites < 1,300 m). Across error metrics and signatures, parameter sensitivity strongly differed between wet and dry years for a subset of our study sites. While parameter importance varied through time, parameter sensitivity variations across watersheds were much more pronounced. This suggests that parameter controls on model performance are much more a reflection of watershed properties as opposed to being dominantly shaped by shifts in precipitation and air temperature. These findings emphasize the importance of understanding simulated watershed responses to fluctuating annual conditions, as this conceptual knowledge is necessary to anticipate similarities and differences in response across even relatively proximal watersheds in the face of growing extreme conditions. Plain Language Summary Computer models are useful tools that can be used to analyze what inputs matter most to ensuring that model output is similar to observed conditions. In order to understand how very wet years versus very dry years impact which model inputs (called parameters) are most important to matching good predictions, we simulated streamflow using a simple mathematical model many thousands of times. We used these outputs to determine how variations in predictions of streamflow (output from the model) are related to variations in model parameters, to identify which parameters are most important for ensuring reasonable model predictions. We focused on watersheds that are close together, but that may experience different average conditions and interannual variability. We found that which parameters are important varied across different watersheds and also varied with total a...