Linking immunity and hematopoiesis by bone marrow T cell activity

Monteiro, João P.; Bonomo, Adriana

doi:10.1590/s0100-879x2005001000004

Cited by 13 publications

(7 citation statements)

References 53 publications

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“…Activated T cells can produce a range of cytokines such as IL-3, IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ and GM-CSF that regulate hematopoiesis [22,25]. In a T-cell-deficient murine model, terminal differentiation of myeloid progenitor cells is defective if T cells are missing [26]. These lines of evidence suggest that T cells in the BM are crucial for myelopoiesis.…”

Section: Discussionmentioning

confidence: 99%

CD137 ligand signaling enhances myelopoiesis during infections

et al. 2013

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earlier conflicting data by demonstrating that while CD137-CD137L interactions inhibit myelopoiesis during steady-state conditions they increase myelopoiesis during infection.Keywords: BM r CD137 r Infection r Myelopoiesis r T cellsAdditional supporting information may be found in the online version of this article at the publisher's web-site Introduction CD137 (TNFRSF9, 4-1BB, induced by lymphocyte activation, ILA) is a member of the tumor necrosis factor (TNF) receptor familyCorrespondence: Dr. Herbert Schwarz e-mail: phssh@nus.edu.sg [1,2]. CD137 is highly expressed by T cells following activation, and crosslinking of CD137 delivers potent costimulatory signals to T cells [3]. CD137 agonists enhance T-cell activity and enable the rejection of even established tumors in mice [4,5]. Stimulation of CD137 also enhances protective immune responses against pathogen infections. Agonistic anti-CD137 Abs have been shown to enhance the efficacy of vaccines against Influenza and poxvirus [6,7]. Inclusion of a CD137 ligand-expressing vector in a vaccine, or engineered expression Eur. J. Immunol. 2013Immunol. . 43: 1555Immunol. -1567 of CD137 ligand on monocytes enhanced their ability to induce anti-HIV responses [8,9]. The importance of the CD137 receptorligand system in limiting and clearing viral infections is further testified by the fact that CD137L −/− mice have impaired immunity against lymphocytic choriomeningitis virus [10] and several Influenza virus strains [11,12]. Therefore, the induction of CD137 expression on immune cells in the course of infections can be regarded as part of the anti-pathogen immune response. CD137 ligand (CD137L) is expressed by antigen-presenting cells (APCs), where it serves to costimulate CD137-expressing, activated T cells. The CD137 receptor-ligand system has bidirectional signaling, which is also found at other members of the TNF receptor-ligand families [13]. Bidirectional signaling is possible because CD137L, just like CD137, is expressed as a transmembrane protein on the cell surface and transmits a signal into the cell it is expressed on, a process referred to as reverse signaling [14]. For APCs the CD137L signal is activating. CD137L signaling enhances the activities of all APCs, and thereby contributes to the elimination of the pathogen [15].However, CD137L signaling may enhance the anti-pathogen response by an additional mechanism, i.e. by the induction of myelopoiesis resulting in the generation of more myeloid cells that can enhance the strength and efficiency of the anti-pathogen immune response. This hypothesis is based on our recent findings that the CD137 receptor-ligand system not only regulates the activities of mature immune cells but also induces proliferation of hematopoietic progenitor cells, and their differentiation to myeloid cells, in particular to macrophages [16,17]. However, it has also been reported that CD137−/− and CD137L −/− mice have higher numbers of myeloid cells in the BM than WT mice suggesting an inhibitory effect of CD137 on myelopoiesis [18]. ...

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Section: Discussionmentioning

confidence: 99%

CD137 ligand signaling enhances myelopoiesis during infections

et al. 2013

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“…In this sense, the bone marrow, which is the main hematopoietic organ of an adult organism, maintains a close relationship with the immune system. The bone marrow is able to respond to acute infections by using an emergency hematopoiesis in order to release immune cells (Monteiro & Bonomo, 2005). Therefore, we next studied the cellular changes in bone marrow during the pneumococcal infection and the influence of the CRL1505 strain, with special attention to myelopoiesis.…”

Section: Bone Marrow Myeloid Cellsmentioning

confidence: 99%

Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

Herrera

Salva

Villena

et al. 2013

Journal of Functional Foods

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“…This increase is accompanied by a decrease in CD4 + T cells in the spleen and lung. It is possible that the bone marrow tries to restore normal hematopoiesis in the face of hypoplasia-induced stress present in protein malnutrition ( 63 , 74 , 75 ). In the protection against S. pneumoniae , the induction and maintenance of antigen specific T cell responses is essential.…”

Section: Protein-malnutrition Impairs the Respiratory Specific Immune Response Against Pneumococcal Infectionmentioning

confidence: 99%

The Role of Immunobiotics and Postbiotics in the Recovery of Immune Cell Populations From Respiratory Mucosa of Malnourished Hosts: Effect on the Resistance Against Respiratory Infections

et al. 2021

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Malnutrition is associated with a state of secondary immunodeficiency, which is characterized by a worsening of the immune response against infectious agents. Despite important advances in vaccines and antibiotic therapies, the respiratory infections are among the leading causes of increased morbidity and mortality, especially in immunosuppressed hosts. In this review, we examine the interactions between immunobiotics-postbiotics and the immune cell populations of the respiratory mucosa. In addition, we discuss how this cross talk affects the maintenance of a normal generation of immune cells, that is crucial for the establishment of protective innate and adaptive immune responses. Particular attention will be given to the alterations in the development of phagocytic cells, T and B lymphocytes in bone marrow, spleen and thymus in immunosuppression state by protein deprivation. Furthermore, we describe our research that demonstrated that the effectiveness of immunobiotics nasal administration in accelerating the recovery of the respiratory immune response in malnourished hosts. Finally, we propose the peptidoglycan from the immunobiotic Lactobacillus rhamnosus CRL1505 as the key cellular component for the effects on mucosal immunity, which are unique and cannot be extrapolated to other L. rhamnosus or probiotic strains. In this way, we provide the scientific bases for its application as a mucosal adjuvant in health plans, mainly aimed to improve the immune response of immunocompromised hosts. The search for safe vaccine adjuvants that increase their effectiveness at the mucosal level is a problem of great scientific relevance today.

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Linking immunity and hematopoiesis by bone marrow T cell activity

Cited by 13 publications

References 53 publications

CD137 ligand signaling enhances myelopoiesis during infections

CD137 ligand signaling enhances myelopoiesis during infections

Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

The Role of Immunobiotics and Postbiotics in the Recovery of Immune Cell Populations From Respiratory Mucosa of Malnourished Hosts: Effect on the Resistance Against Respiratory Infections

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