Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

Zhou, Rui-Xin; Zhang, Yuan‐Wei; Cao, Mu-Min; Liu, Cun-Hao; Menemenlis, Dimitris; Li, Yingjuan

doi:10.1007/s00774-023-01415-0

Cited by 13 publications

(10 citation statements)

References 148 publications

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“…In recent years, several human and animal researches have reported that the supplementation of probiotics can promote osteoblast-related bone formation and osteoclastrelated bone absorption to obtain balance via a variety of different expression of immunoglobulin A to enhance the immune system of body (Li, Zhang, et al, 2022;Liu et al, 2022). More importantly, the supplementation of probiotics can also directly repair damaged intestinal mucosal barrier, inhibit intestinal inflammation, and thus preventing the pro-inflammatory cytokines from acting on the bones of body with the blood circulation (Zhang, Cao, Li, Lu, Dai, Zhang, Wang, & Rui, 2022;Zhang, Cao, Li, Zhang, Wu, Yu, & Rui, 2022;Zhou et al, 2023). Liu et al (2019) showed via a study that the administration of Lactobacillus rhamnosus GG gut microbiota, and the reduction in release of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding this, several previous studies have also reported that the supplementation of different types of probiotics is able to promote the expression of anti‐inflammatory cytokines and reduce expression of pro‐inflammatory cytokines, thus alleviating the intestinal and systemic inflammation and promoting the expression of immunoglobulin A to enhance the immune system of body (Li, Zhang, et al, 2022 ; Liu et al, 2022 ). More importantly, the supplementation of probiotics can also directly repair damaged intestinal mucosal barrier, inhibit intestinal inflammation, and thus preventing the pro‐inflammatory cytokines from acting on the bones of body with the blood circulation (Zhang, Cao, Li, Lu, Dai, Zhang, Wang, & Rui, 2022 ; Zhang, Cao, Li, Zhang, Wu, Yu, & Rui, 2022 ; Zhou et al, 2023 ). Liu et al ( 2019 ) showed via a study that the administration of Lactobacillus rhamnosus GG for 8 consecutive weeks can reverse the bone loss induced by tenofovir fumarate diester in mice by repairing the integrity of intestinal mucosal barrier, increasing Treg cells and reducing Th17 cells, and downregulating the osteoclast‐related factors in bone marrow, spleen, and intestine.…”

Section: Discussionmentioning

confidence: 99%

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The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy‐induced osteoporosis

Li,

Zhang,

Cao

et al. 2023

Food Science & Nutrition

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There is an inseparable link between bone metabolism and gut microbiota, and the supplementation of probiotics exhibits a significant role in maintaining the homeostasis of gut microbiota and inhibiting bone loss. This study aims to explore the preventive and therapeutic potentials and the specific mechanisms of Rothia on osteoporosis. The mice models of osteoporosis induced by ovariectomy (OVX) were built, and the regular (once a day) and quantitative (200 μL/d) gavage of Rothia was performed for 8 weeks starting from 1 week after OVX. Microcomputed tomography was used to analyze the bone mass and bone microstructure of mice in each group after sacrifice. Histological staining and immunohistochemistry were then applied to identify the expression of pro‐inflammatory cytokines, intestinal permeability, and osteogenic and osteoclastic activities of mice. The collected feces of mice in each group were used for 16S rRNA high‐throughput sequencing to detect the alterations in composition, abundance, and diversity of gut microbiota. This study demonstrated that the gavage of Rothia alleviated bone loss in mice with OVX‐induced osteoporosis, improved OVX‐induced intestinal mucosal barrier injury, optimized intestinal permeability (zonula occludens protein 1 and occludin), reduced intestinal inflammation (tumor necrosis factor‐α and interleukin‐1β), and regulated imbalance of gut microbiota. Based on “gut‐bone” axis, this study revealed that regular and quantitative gavage of Rothia can relieve bone loss in mice with OVX‐induced osteoporosis by repairing the intestinal mucosal barrier injury, optimizing the intestinal permeability, inhibiting the release of pro‐inflammatory cytokines, and improving the disorder of gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy‐induced osteoporosis

Li,

Zhang,

Cao

et al. 2023

Food Science & Nutrition

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“…The gut microbiota has been established as a critical target in the treatment of several diseases, including several etiologies of osteoporosis and importantly GIO ( Sjögren et al, 2012 ; Villa et al, 2015 ; Chen et al, 2017 ; Quach and Britton, 2017 ; Rios-Arce et al, 2017 ; Pacifici, 2018 ; Hao et al, 2019 ; Schepper et al, 2020 ; Knudsen et al, 2021 ; Tu et al, 2021 ; Cronin et al, 2022 ; Chargo et al, 2023 ; Zhou et al, 2023 ). We have shown that chronic GC treatment alters the composition of the gut microbiota, leading to an imbalance, or dysbiosis, within the microbial community present ( Schepper et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice

Chargo,

Neugebauer,

Guzior

et al. 2024

Front. Cell Dev. Biol.

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Glucocorticoid-induced osteoporosis (GIO) is a significant side effect of prolonged glucocorticoid (GC) treatment. Chronic GC treatment also leads to trabecular bone loss and gut microbiota dysbiosis in mice. The gut dysbiosis is mechanistically linked to GIO, which indicates that the microbiota can be targeted to prevent GIO. Prunes, a dried fruit and prebiotic, have emerged in the literature as an effective treatment for sex-steroid deficiency induced osteoporosis (primary osteoporosis). Prunes also significantly alter the composition of the gut microbiota in both rodent models and human studies. Therefore, we tested if dietary prune (DP) supplementation could prevent GC-induced bone loss and affect microbiota composition in an established model of GIO. Sixteen-week-old, skeletally mature, female C57BL/6J mice were treated with a subcutaneous 5 mg placebo or prednisolone pellet for 8 weeks and fed an AIN-93M control diet or a diet modified to include 5, 15, or 25% (w/w) dried California prune powder. As expected, GC treated mice developed significant trabecular bone loss in the distal femur. More importantly, as little as 5% DP supplementation effectively prevented trabecular bone loss. Further, dose dependent increases in trabecular bone volume fraction were observed in GC + 15% and GC + 25% DP mice. Amazingly, in the placebo (non-GC treated) groups, 25% DP supplementation caused a ∼3-fold increase in distal femur trabecular bone volume fraction; this sizable bone response has not been previously observed in healthy mice with gut targeted natural treatments. Along with the striking effect on bone health, GC treatment and 25% DP supplementation led to drastic shifts in gut microbiota composition and several specific changes are strongly associated with bone health. Taken together, these results are the first to demonstrate that DP supplementation effectively prevents the negative effects of prolonged GC therapy on trabecular bone health and strongly associates with shifts in the composition of the gut microbiota.

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“…According to a previous report by Ling et al, 5 the risk of osteoporotic fractures in the patients with osteoporosis was as high as 40%, while the occurrence of osteoporosis was not easy to be noticed. Of note, most patients are diagnosed after the occurrence of brittle fractures, which delays the most proper time for the prevention and treatment 6,7 . Therefore, the early screening and diagnosis of osteoporosis is particularly significant 8 …”

Section: Introductionmentioning

confidence: 99%

“…Of note, most patients are diagnosed after the occurrence of brittle fractures, which delays the most proper time for the prevention and treatment. 6,7 Therefore, the early screening and diagnosis of osteoporosis is particularly significant. 8 Currently, the World Health Organization recommends using dual energy X-ray absorptiometry (DXA) to determine the bone mineral density (BMD) of the test population, and further defines different degrees of BMD as three levels, including the osteoporosis, osteopenia, and normal bone mass.…”

Section: Introductionmentioning

confidence: 99%

High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study

Zhang,

2023

Immunity Inflam & Disease

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BackgroundAs one of novel inflammatory indexes proposed in recent years, systemic immune‐inflammation index (SII) can comprehensively reflect the inflammatory and immune state of the body. This study aims to explore the relationship between SII and osteoporosis among middle‐aged and older people.Materials and MethodsOur study includes 20,497 individuals from National Health and Nutrition Examination Survey (NHANES) 2005–2008, and target study population are confined to people aged 45 years and above. SII is calculated as platelet count × neutrophil count/lymphocyte count. Multivariate logistic regression analysis is used to explore the link between SII and osteoporosis, and receiver operating characteristics curve is used to screen optimal cut‐off value of SII for indicating the occurrence of osteoporosis.ResultsA total of 435 people with osteoporosis are screened among 4625 middle‐aged and older people, and individuals in osteoporosis group have higher SII than those in nonosteoporosis group (p = .024). Logistic regression analysis indicates that with the enhancement of SII, prevalence of osteoporosis in each tertile category also increases (p < .001). This tendency is also not changed in univariate model (p < .001), as well as the adjustments for different parameters. Moreover, we also identify that SII of 530.09 is the optimal cut‐off value for indicating the occurrence of osteoporosis among middle‐aged and older people.ConclusionsThis present NHANES‐based study noticed that higher SII is positively linked to osteoporosis among middle‐aged and older people, and SII should not exceed 530.09 for them to obtain a potentially lower risk of osteoporosis.

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Linking the relation between gut microbiota and glucocorticoid-induced osteoporosis

Cited by 13 publications

References 148 publications

The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy‐induced osteoporosis

The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy‐induced osteoporosis

Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice

High systemic immune‐inflammation index is relevant to osteoporosis among middle‐aged and older people: A cross‐sectional study

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