Links Between Paraquat and Parkinson’s Disease

Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism

“…Paraquat (PQ) has been mainly demonstrated to induce cell death in a variety of cell types and tissues associated with PD. The study of PQ-induced neurotoxicity has provided valuable insight into the mechanisms regulating neuronal cell death by environmental toxicants (González-Polo et al, 2014). Our findings from 'oxidative stress assay' viz., low incidence of mortality and improved locomotor phenotype observed among flies provided with SME/CR prophylaxis clearly suggests their propensity to alleviate oxidative stress.…”

Neuromodulatory Potential of Aqueous Extracts of Cumin, Cinnamon: Evidence from Rotenone Model in Drosophila: Implications to Parkinson’s Disease

“…Studies on PQ neurotoxicity have offered valuable insights into the mechanisms of neuronal cell death induced by environmental toxicants [61] . In the prophylactic study with bioactives, our principal findings viz., low incidence of mortality and the associated improved locomotor behavior among PQ exposed flies suggests their potential to decrease oxidative stress and increase survival pathways.…”