Linoleic and arachidonic acid in perinatal asphyxia and prematurity

Labadaridis, I; Μωραιτου, Μαρινα; Theodoraki, Martha; Dimitriou, Evangelia; Sarafidou, Jasmin; Michelakakis, Helen

doi:10.1080/14767050701449745

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Indeed, the plasma trienoic acid/tetraenoic acid ratio was less than 0.4 (data not shown), and the EFA status index in RBC (averages from 1.6 to 1.8 all through the study period; data not shown) was relatively close to the values (i.e., 2.1) reported in 26-36 weeks healthy preterm newborns [33]. In addition, the LA concentration of total plasma lipids was in the upper range of values previously published in healthy premature neonates of 26-36 weeks of GA, themselves very similar to values found in healthy full-term newborns (i.e., 90 to 500 mg/L) [34]. The same remark can be made for the ARA concentration of plasma total lipids, which was within the range previously reported (120-270 mg/L) [34].…”

Section: Discussionsupporting

confidence: 87%

“…In addition, the LA concentration of total plasma lipids was in the upper range of values previously published in healthy premature neonates of 26-36 weeks of GA, themselves very similar to values found in healthy full-term newborns (i.e., 90 to 500 mg/L) [34]. The same remark can be made for the ARA concentration of plasma total lipids, which was within the range previously reported (120-270 mg/L) [34]. In the study by Soriano et al [30] that showed no change in plasma LA and ARA levels in premature neonates after massage with soybean, neonates were also not EFA deficient (16-18% LA and 9.4-10% ARA of total FA in total plasma lipids).…”

Section: Discussionsupporting

confidence: 87%

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Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study

et al. 2022

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Background: Oil massage versus only massage can increase preterm newborn development, especially weight gain, via a supposed percutaneous absorption of oil lipids, but data are contradictory. Aims: Investigating whether massage with a vegetable oil balanced in essential fatty acids improves neonatal weight gain, and digestive autonomy as proxy for neuro-development outcomes. Methods: A prospective monocentric randomized study was conducted in very premature newborns who received massage with oil (isio4 10 mL/kg/day, n = 18) versus with no oil (n = 18) for five consecutive days (10-min session twice daily) at a corrected gestational age of 34–35 weeks. Anthropometrics and clinical characteristics were recorded. Plasma triglyceride and total cholesterol concentrations were analyzed with an enzymatic kit. The fatty acid composition (weight%, mg/mL) of total plasma lipids and of red blood cell (RBC) membrane was analyzed by gas chromatography. Results: Weight gain velocity at the end of massage period was 12.3 ± 1.4 g/kg/day with oil vs. 9.8 ± 1.4 g/kg/day with no oil (p = 0.1). Digestive autonomy, plasma lipid parameters, polyunsaturated fatty acids in plasma total lipids or in RBC were comparable. The no oil group displayed a higher RBC level in nervonic acid at discharge (4.3 ± 0.2 vs. 3.4 ± 0.2%; p = 0.025) and in C18:1n-9 plasmalogen species at the end of the massage period and at discharge (0.73 ± 0.06 vs. 0.48 ± 0.06; 0.92 ± 0.06 vs. 0.69 ± 0.06%; p < 0.01), two molecules that are involved in neurodevelopment. Conclusions: The use of isio4 oil did not provide additional benefits for the development of very premature newborns, neither changed lipid metabolism nor polyunsaturated fatty acid biological status, which did not corroborate the existence of a percutaneous route for oil lipid absorption. The reason for different levels of nervonic acid and plasmalogen in RBC remains to be explored.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Effect of Massage with Oil Balanced in Essential Fatty Acids on Development and Lipid Parameters in Very Premature Neonates: A Randomized, Controlled Study

et al. 2022

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“…The main causes of oxidative stress in the newborn period are associated with oxygen administration [8], mechanical ventilation [9], intermittent hypoxia and apnea episodes [10], and asphyxia [11]. In general, the fetal-to-neonatal transition is characterized by intermittent hypoxia periods, involving over-production of oxidative substances and a disequilibrium in important cellular pathways, such as oxidation or inflammation biomolecules [12].…”

Section: Oxidative Stress In Preterm Infantsmentioning

confidence: 99%

Non-invasive assessment of oxidative stress in preterm infants

Peña-Bautista

Durand

Vigor

et al. 2019

Free Radical Biology and Medicine

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Preterm newborns have an immature antioxidant defense system and are especially susceptible to oxidative stress. Resuscitation, mechanical ventilation, intermittent hypoxia and apneic episodes require frequently oxygen supplementation which leads to oxidative stress in preterm newborns. The consequences of oxidative damage are increased short and long-term morbidities, neurodevelopmental impairment and increased mortality.Oxidative stress biomarkers are determined in blood samples from preterm children during their stay in neonatal intensive care units especially for research purposes. However, there is a tendency towards reducing invasive and painful techniques in the NICU (Neonatal Intensive Care Unit) and avoiding excessive blood extractions procedures.In this paper, it has been described some studies that employed non-invasive samples to determine oxidative stress biomarkers form preterm infants in order to perform a close monitoring biomarker with a significant greater predictive value. Among these methods we describe a previously developed and validated high-performance liquid chromatography tandem mass spectrometry method that allow to accurately determine the most reliable biomarkers in biofluids, which are non-invasively and painlessly obtained.

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“…Unfortunately, relatively few of these interventions have been found to be effective. Although low plasma concentrations of long‐chain polyunsaturated fatty acids have been documented in asphyxiated and infants born preterm, a systematic review of long‐chain polyunsaturated fatty acids supplementation in infants born preterm did not find any evidence of benefit …”

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confidence: 98%