Lip leishmaniasis

El-Hoshy, Khaled

doi:10.1016/s0190-9622(08)81793-8

Cited by 11 publications

(8 citation statements)

References 4 publications

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“…The finding of Leishmania amastigotes after biopsy examination was unexpected. The atypical presentation of the infection, with marked involvement of the whole mucocutaneous surface of the inferior labrum, most likely reflects the uncommon site of inoculation of the protozoa, 4–6,12 which was transmitted from the bites of flying vectors. Nevertheless, in a large epidemiological and clinical report on the cutaneous features of leishmaniasis in Sanliurfa (Turkey), lip involvement was present in only 4.4% of cases 13 .…”

Section: Discussionmentioning

confidence: 99%

Leishmaniasis of the lip in a patient with Down's syndrome

Ferreli

Atzori

Zucca

et al. 2004

Acad Dermatol Venereol

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Cutaneous leishmaniasis is an endemic protozoan infection in Sardinia, one of the major islands of the Mediterranean Basin. The main causative strain in this country is Leishmania infantum, which rarely involves mucocutaneous areas, but has the potential to cause visceral leishmaniasis. An atypical leishmaniasis involving the inferior lip of a 57-year-old female with Down's syndrome was observed at the Dermatology Department of Cagliari (italy). The diagnosis was mainly based upon histopathological examination, revealing intra- and extra-cellular leishmania amastigotes. The leishmania infantum zymodeme MON-111 was identified by isoenzymatic characterization. Laboratory investigations revealed a normal complete blood count and biochemistry profile, except for an inverted CD4/CD8 ratio. Treatment with meglumine antimoniate 60 mg/kg/day (Glucantime) intramuscularly for 15 days, followed by intralesional administration 1 ml weekly for 4 weeks led to complete recovery. No relapses were observed at 6-month follow-up. The unusual localization is likely to be a reflection of the uncommon site of inoculation of the protozoa, transmitted by bites from flying vectors. Nevertheless, the presence of Down's syndrome in our patient may have contributed to the atypical presentation by traumatic exacerbation of the lesion, due to repeated auto-induced microtraumas of the inferior lip accompanied by subclinical immunodeficiency. In fact, the specific immune response to Leishmania infection depends on a host-cell-mediated immune response, reported as defective in Down's syndrome patients. Differential diagnosis and early detection of the infection are necessary in order to start effective treatment and prevent more serious complications.

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Section: Discussionmentioning

confidence: 99%

Leishmaniasis of the lip in a patient with Down's syndrome

Ferreli

Atzori

Zucca

et al. 2004

Acad Dermatol Venereol

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“…Herein, the reported cases showed an unusual clinical presentation of OWCL with mucosal involvement. El‐Hoshy 2 reported 12 cases of CL on the lips from Saudi Arabia and stated that this localization is common, although rarely reported in the published work. In 2002, Gurel et al 3 .…”

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confidence: 99%

Effectiveness of intralesional meglumine antimoniate in the treatment of mucosal leishmaniasis of the Old World

Zarâa

Karoui

Osman

2011

The Journal of Dermatology

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“…Leishmania granuloma may also be observed in atypical locations of the human body that are not usually exposed to sandfly bites, such as the fingers (paronychial CL 54 ), palms and feet (palmoplantar 54 ), lips (macrochelia 56 ), eyelids, and genitals (chancriform and trichophytoid CL 54 on the shaft of the penis). Different anatomic structures of the skin in these unusual locations are predisposed to the development of lesions with different morphology than typically observed on the skin with a prominent dermal layer.…”

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confidence: 99%