Lipase/amylase ratio

Gumaste, Vivek; Dave, Pradyuman B.; Weissman, Douglas; Messer, Julio

doi:10.1016/0016-5085(91)90089-4

Cited by 81 publications

(4 citation statements)

References 23 publications

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“…(i) This is a retrospective study, which may have selection bias. Because of the retrospective design, we did not investigate other risk factors of severe acute pancreatitis such as lipase [56], prealbumin/fibrinogen [57], and red cell distribution width [58]. (ii) Data were collected in a single tertiary care hospital, which may not be generalized to a local clinic or a community hospital.…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Hong

Lin

Zippi

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Background and Aims To investigate the association between serum albumin levels within 24 hrs of patient admission and the development of persistent organ failure in acute pancreatitis. Methods A total of 700 patients with acute pancreatitis were enrolled. Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. The diagnostic performance of serum albumin was evaluated by the area under Receiver Operating Characteristic (ROC) curves. Results As levels of serum albumin decrease, the risk of persistent organ failure significantly increases (Ptrend < 0.001). The incidence of organ failure was 3.5%, 10.6%, and 41.6% in patients with normal albumin and mild and severe hypoalbuminaemia, respectively. Decreased albumin levels were also proportionally associated with prolonged hospital stay (Ptrend < 0.001) and the risk of death (Ptrend < 0.001). Multivariate analysis suggested that biliary etiology, chronic concomitant diseases, hematocrit, blood urea nitrogen, and the serum albumin level were independently associated with persistent organ failure. Blood urea nitrogen and the serum albumin level were also independently associated with mortality. The area under ROC curves of albumin for predicting organ failure and mortality were 0.78 and 0.87, respectively. Conclusion A low serum albumin is independently associated with an increased risk of developing of persistent organ failure and death in acute pancreatitis. It may also be useful for the prediction of the severity of acute pancreatitis.

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Section: Discussionmentioning

confidence: 99%

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Hong

Lin

Zippi

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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“…The L/A ratio is an acceptable indicator of alcohol-induced pancreatitis [41]. In fact, L/A ratio can be used to distinguish between pancreatitis caused by alcohol use and pancreatitis not caused by alcohol [42]. Patients diagnosed with alcohol-induced pancreatitis have a twofold increased likelihood of having an L/A ratio of three or higher with a sensitivity of 75% and a specificity of 56% [43].…”

Section: Biochemical Evaluationmentioning

confidence: 99%

β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview

Sandoval,

Vera,

Birditt

et al. 2024

IJMS

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Alcohol is believed to harm acinar cells, pancreatic ductal epithelium, and pancreatic stellate cells. After giving ethanol and/or β-carotene to C57BL/6 mice, our goal was to evaluate their biochemistry, histology, and morpho-quantitative features. There were six groups of C57BL/6 mice: 1. Group C (control), 2. Group LA (low-dose alcohol), 3. Group MA (moderate-dose alcohol), 4. Group B (β-carotene), 5. Group LA + B (low-dose alcohol combined with β-carotene), and 6. Group MA + B (moderate-dose alcohol combined with β-carotene). After the animals were euthanized on day 28, each specimen’s pancreatic tissue was taken. Lipase, uric acid, and amylase were assessed using biochemical assessment. Furthermore, the examination of the pancreatic structure was conducted using Ammann’s fibrosis scoring system. Finally, the morpho-quantitative characteristics of the pancreatic islets and acinar cells were determined. In the serum of the MA + B group, there were higher amounts of total amylase (825.953 ± 193.412 U/L) and lower amounts of lipase (47.139 ± 6.099 U/L) (p < 0.05). Furthermore, Ammann’s fibrosis punctuation in the pancreas revealed significant variations between the groups (p < 0.001). Finally, the stereological analysis of pancreatic islets showed that the groups were different (p < 0.001). These findings suggest that antioxidant treatments might help decrease the negative effects of ethanol exposure in animal models.

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“…There is conflicting data with respect to the utility of lipase-to-amylase ratio in determining the cause of acute pancreatitis. A prospective study found an increased lipase-to-amylase ratio of greater than two to be indicative of alcoholic pancreatitis, however, many retrospective studies found a ratio greater than five to be predictive of the same [43][44][45]. Another study found the ratio to be suggestive of biliary etiology [46].…”

Section: Amylase Vs Lipase For the Diagnosis Of Acute Pancreatitismentioning

confidence: 99%

Interpretation of serum pancreatic enzymes in pancreatic and nonpancreatic conditions

Bush

Akshintala

2023

Current Opinion in Gastroenterology

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Purpose of review Serum levels of amylase and lipase can be elevated in nonpancreatic conditions that may or may not be associated with abdominal pain. This leads to a large proportion of patients being falsely labeled as having acute pancreatitis. In this review, we aim to summarize the existing evidence on pancreatic enzyme elevation in various pancreatic and nonpancreatic conditions and its practical implications in clinical practice and healthcare. Recent findings Serum amylase and lipase levels are not specific for pancreatitis. Attempts have been made to validate newer biomarkers including pancreatic elastase, serum trypsin, urinary trypsinogen-activated peptide, phospholipase A2, carboxypeptidase B, activated peptide of carboxypeptidase B, the trypsin 2 alpha 1 activation complex, and circulating cell-free DNA for the diagnosis of acute pancreatitis. Summary Serum lipase levels can be elevated in many intra-abdominal inflammatory conditions. Although more sensitive and specific than amylase, serum lipase levels are not sufficient to diagnose acute pancreatitis in patients with abdominal pain. There is a need to increase stress on radiological evidence as well increase cut-off levels of enzyme elevation for a more accurate diagnosis of acute pancreatitis.

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Lipase/amylase ratio

Cited by 81 publications

References 23 publications

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis

β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview

Interpretation of serum pancreatic enzymes in pancreatic and nonpancreatic conditions

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