Lipase inhibitory activity of  Lagenaria siceraria  fruit as a strategy to treat obesity

Maqsood, Maria; Ahmed, Dildar; Atique, Iqra; Malik, Wajeeha

doi:10.1016/j.apjtm.2017.03.010

Cited by 54 publications

(34 citation statements)

References 14 publications

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“…In addition, CME contains anti-hyperglycemic compounds, furanoeudesma-1,3-diene and 2-O-acetyl-8,12-epoxygermacra-1 [37] and has stimulatory effect on β cells division and insulin secretion [18,65]. Benzofuranebisindole hybrids have been shown to have in vitro antioxidant effect and in vivo anti-dyslipidemic activity as it decreases total cholesterol, triglycerides and phospholipids through increasing the plasma lecithin cholesterol acyltransferase activity, which plays a key role in lipoprotein metabolism increasing HDL-C in serum level [66].…”

Section: Discussionmentioning

confidence: 99%

Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats

et al. 2020

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This study was performed to evaluate anti-obesity potential of Commiphora myrrha resin ethanolic extract (CME) with the respect to expression of leptin, adiponectin and uncoupling protein 1 (UCP1) in rats. Control rats fed basal diet. Second group fed basal diet and administered CME (500 mg/kg bw) orally for 14 weeks. Third group fed high fat diet (HFD) for 14 weeks. Fourth group fed HFD and administered CME as second group. Fifth group fed HFD for 8 weeks then fed basal diet and administered CME as third group for another 6 weeks. Phytochemical analysis of CME identified the presence of germacrene B, 1,4-benzoquinone, benzofuran, hexadecanoic acid, 9,12-octadecnoic acid methyl ester, reynosin, 11, 14-eicosadienoic acid, isochiapin B, bisabolene epixod, elemene and 1-heptatriacotanol. High fat diet significantly increased food intake, body weight, hyperglycemia, serum levels of total cholesterol, triacylglycerol, low density lipoprotein and ketone bodies, AST and AST activities, concentration of malondialdehyde and histopathological changes in hepatic tissues. However, it significantly reduced serum levels of high density lipoprotein, leptin and adiponectin, activity of hepatic glutathione reductase (GR) and brown adipose tissue UCP1 protein expression. In contrast, CME ameliorated HFD increased body weight, hyperglycemia, dyslipidemia, ketonemia, hepatic tissues lipid peroxidation, restored hepatic tissue architecture and enhanced protein expression of leptin, adiponectin and UCP1 and activity of hepatic GR. This study indicated that CME ameliorated HFD induced hyperglycemia and dyslipidemia through normalization of HFD reduced leptin, adiponectin and UCP1 proteins production and antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats

et al. 2020

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“…Figure 2b these two extracts both present lipase inhibitory activities in a concentration-dependent manner, indicating a possible likeness in their action mechanism. There are studies indicated that the lipase inhibitory constituents could be better extracted from plants when water be the solvent, compared to methanol (Maqsood, Ahmed, Atique, & Malik, 2017). A great deal of edible Allium from Liliaceae family had been shown to exhibit favorable effects on antiobesity and oxidative stress, such as Allium sativum L. (Kim, Kim, Kim, & Om, 2013), Allium fistulosum L. (Sung, Yoon, Kim, Yang, & Kim, 2011), and Allium cepa L. (Kumari & Augusti, 2007).…”

Section: α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

Phenolic compounds and bioactivity evaluation of aqueous and methanol extracts ofAllium mongolicumRegel

Wang

Zhang

et al. 2019

Food Science & Nutrition

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Allium mongolicum Regel (AM), widely distributed in western China, is a traditional Mongolian medicine herb. Two different solvents as water and methanol were used to extract AM, and their antioxidant capacity and inhibitory effects against key enzymes related to metabolic syndrome were assessed. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS and reducing power assays. In addition, the total phenolic content and total flavonoids content were quantificated and analyzed. Aqueous extract, having higher phenolic content (10.20 mg GAE/g DW) and flavonoid content (4.02 mg QE/g DW), showed better antioxidant and inhibitory effects against lipase and angiotensin‐converting enzyme (ACE); as for α‐glucosidase, the extract made by methanol showed better ability. In general, the aqueous extract of A. mongolicum Regel has the potential to be used as a functional food or nutraceutical in prevention and treatment of obesity and hypertension due to the high antioxidant and sound inhibitory potential against vital enzymes relevant to obesity and hypertension.

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“…Kondisi obesitas dapat menyebabkan terjadinya kelainan metabolisme lipid yang ditandai dengan kelainan profil lipid dalam plasma seperti kadar kolesterol total yang tinggi, kadar trigliserida yang tinggi, dan kadar kolesterol highdensity lipoprotein (HDL) yang rendah. Absorpsi asam lemak dalam tubuh sebagai langkah awal dalam metabolisme lipid dapat diturunkan dengan menghambat aktivitas enzim lipase pankreas sebagai target antiobesitas (Maqsood et al, 2017;Nomura and Casida, 2016). Kondisi hiperkolesterolemia tentunya akan membaik ketika metabolisme lipid dalam tubuh kembali normal.…”

Section: Pendahuluanunclassified

Antiobesity and antihypercholesterolemic effects of white tea (Camellia sinensis) infusion on high-fat diet induced obese rats

Shiyan

Herlina²,

Bella³

2017

Pharmaciana

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ABSTRAKKondisi obesitas dapat menyebabkan metabolime lipid terganggu sehingga menjadi faktor resiko hiperkolesterolemia. Katekin dan epigallocatechin gallate dalam white tea berpotensi sebagai penghambat aktivitas enzim lipase. Senyawa kafein dan derivat katekin memiliki peran sebagai antihiperkolesterolemia. Penelitian ini bertujuan untuk melihat efek antiobesitas dan antihiperkolesterolemia dari seduhan white tea terhadap kadar lipase serum serta kolesterol total serum pada tikus yang diberi diet lemak tinggi. Tikus dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif yang diberi air suling, kelompok kontrol positif yang diberi orlistat dosis 14,2 mg/kgBB, dan kelompok seduhan white tea dengan dosis per hari yang diberikan masing-masing yaitu 125, 250 dan 500 mg/kgBB. Pakan diet lemak tinggi diberikan selama 50 hari untuk menginduksi obesitas pada semua kelompok. Parameter yang diukur meliputi kadar lipase serum dan kadar kolesterol total serum yang diukur sebelum maupun setelah pemberian diet lemak tinggi dan setelah pemberian perlakuan. Berat badan dihitung setiap 5 hari sekali selama masa perlakuan dan asupan pakan dihitung setiap hari selama perlakuan. Seduhan white tea dosis 500 mg/kgBB dapat menurunkan kolesterol total serum sebesar 37,16±11 mg/dL, kadar lipase serum sebesar 23,70±0,64 U/L, berat badan hingga 3,53±1,21 g/hari dan menurunkan asupan pakan sebesar 12,71±1,76 g/hari. Seduhan white tea dapat menurunkan kadar kolesterol total, kadar lipase serum, berat badan dan asupan pakan. Kesimpulan dari penelitian ini bahwa seduhan white tea memiliki efek antiobesitas dan antihiperkolesterolemia pada tikus yang diberi diet lemak tinggi.Kata kunci: white tea, antiobesitas, antihiperkolesterolemia, diet lemak tinggi, kolesterol total, lipase ABSTRACT Obesity may cause the lipid metabolisms disorder so that a risk factor for hypercholesterolemic. Catechin and epigallocatechin gallate in white tea potentially inhibit lipase activity. Caffeine compounds and catechin derivatives have a role as antihypercholesterolemic. The objective of this study was to explore antiobesity and antihypercholesterolemic activity from white tea infusions to lipase and total cholesterol in rats model fed a high-fat-diet. Twenty-five rats were divided into five groups. Negative control group was administered with distilled water. Shiyan et al.,) Antiobesitas dan antihiperkolesterolemia … ( 279The positive control group was administered with orlistat dose 14.2 mg/kgBW. Group 3 rd , 4 th , and 5 th were treated with white tea infussion doses of 125, 250 and 500 mg/kgBW/day, respectivelly. period and feed intake was calculated daily during the treatment. White tea doses of 500 mg/kgBW decrease the total cholesterol by 37.16±11 mg/dL, lipase level of 23.70±0.64 U/L, weight up to 3.53±1.21 g/day and decrease feed intake by 12.71±1.76 g/day. The infusion of white tea can decrease total cholesterol level, lipase level, body weight and feed intake. This study concluded that infusion of white tea has antiobesity and antihypercholesterole...

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Lipase inhibitory activity of Lagenaria siceraria fruit as a strategy to treat obesity

Cited by 54 publications

References 14 publications

Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats

Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats

Phenolic compounds and bioactivity evaluation of aqueous and methanol extracts ofAllium mongolicumRegel

Antiobesity and antihypercholesterolemic effects of white tea (Camellia sinensis) infusion on high-fat diet induced obese rats

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