Lipid accumulation, oxidative stress and immune-related molecules affected by tributyltin exposure in muscle tissues of rare minnow ( Gobiocypris rarus )

Zhang, Jiliang; Zhang, Chunnuan; Ma, Dongdong; Liu, Min; Huang, Shuntao

doi:10.1016/j.fsi.2017.09.066

Cited by 20 publications

(16 citation statements)

References 66 publications

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“…The use of TBT in antifouling paints has directed a large number of studies on TBT exposure in aquatic species. Most TBT studies carried out in fish involved environmentally relevant doses (range: ~1–100 ng/l), and have demonstrated that TBT increases body weight, adipose tissue mass, triglycerides, and cholesterol [30–34]. The vulnerability of these species to TBT is further supported by the diversity of exposure windows (post fertilization days 5–15, pre-hatch to 9 months, and adult), all of which resulted in obesogenic effects [30–34].…”

Section: Obesogenic Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps

Veiga-López¹,

Pu²,

Gingrich³

et al. 2018

Trends in Endocrinology & Metabolism

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Endocrine disrupting chemicals (EDCs) are compounds that are part of everyday consumer products and industrial manufacturing processes. EDCs can interfere with the endocrine system, including the adipose tissue. Accumulating evidence from epidemiological, animal, and in vitro studies demonstrates that EDCs can alter body weight, adipose tissue expansion, circulating lipid profile, and adipogenesis, with some resulting in transgenerational effects. These outcomes appear to be mediated through multiple mechanisms, from nuclear receptor binding to epigenetic modifications. A better understanding of the signaling pathways via which these EDCs contribute to an obesogenic phenotype, the interaction amongst complex mixtures of obesogenic EDCs, and the risks they pose relative to the obesity epidemic are still needed for risk assessment and development of prevention strategies.

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Section: Obesogenic Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps

Veiga-López¹,

Pu²,

Gingrich³

et al. 2018

Trends in Endocrinology & Metabolism

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“…Also, tributyltin induced lipid accumulation and an increase in total cholesterol and triglycerides in muscle of rare minnows. 34 Accordingly to these observations, the muscle lipidome of B. meridionalis and S. laietanus collected in sites affected by urban and industrial wastewater outflows, was enriched in CEs. This increment of CEs is often accompanied by an induction of the synthesis of TGs.…”

Section: Methodsmentioning

confidence: 71%

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

Marqueño

Blanco

Maceda‐Veiga

et al. 2019

Environ. Sci. Technol.

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This work applies ultra-high performance liquid chromatography coupled to highresolution mass spectrometry (UPLC-HRMS) to characterize for the first time the lipidome of the skeletal muscle of two fish species (Barbus meridionalis, Squalius laietanus) collected in a Mediterranean River affected by urban and industrial wastewater outflows. The untargeted analysis allowed a clear separation of the lipidome of fish from polluted and reference sites; phosphatidylcholines (PCs), phosphatidylethanolamines (PEs) and their lyso and ether-linked forms were among the distinctive features. The targeted analysis consistently detected a decrease in PC

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“…However, previous studies on fish showed different effects of TBT on antioxidant enzyme functionality, related to different doses or animal species (Zhang et al 2017a, b). Indeed, reduction of SOD, CAT and GPx levels has been described in zebrafish liver exposed to 10-100 ng/L TBTC (Zhang et al 2017a) whereas in the muscle of rare minnow exposed to 1-10 ng/L TBT, enzyme activity was found higher than in control group (Zhang et al 2017b). Our results on rainbow trout may suggest that both organotin molecules prompted an overload of the two harmful species such as superoxide anion and hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 95%

“…Increased doses of tributyltin chloride (TBTC) were correlated with a higher malondialdehyde (MDA) concentration, a toxic byproduct of lipid peroxidation and a decreased activity of the main antioxidant enzymes, lysozyme and the content of immunoglobulin M in the liver of D. rerio (Zhang et al 2017a). Changes of lipid accumulation, oxidative stress and immunetoxic effects were also confirmed by Zhang et al (2017b) in the muscle of rare minnow Gobiocypris rarus, concluding that TBT may affect growth and health status of fish. Despite these studies, to our best knowledge, there are no studies on the effects of different tributyl compounds on the levels of oxidative stress biomarkers in rainbow trout Oncorhynchus mykiss.…”

Section: Introductionmentioning

confidence: 99%

Metal load and oxidative stress driven by organotin compounds on rainbow trout

Magara

Elia

Dörr

et al. 2021

Environ Sci Pollut Res

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Tributyltin-based (TBT) antifouling paints, widely used for the treatment of flooded surfaces, have been banned in 2008 for their high environmental persistence and bioaccumulation in aquatic organisms. Although it is still present in aquatic ecosystems, oxidative stress driven by TBT has been still poorly investigated in fish. The aim of the study was to examine the time-course stress responses in liver of rainbow trout that received a single intraperitoneal injection of tributyltin chloride (TBTC) or tributyltin ethoxide (TBTE), both at a dose of 0.05 and 0.5 mg/kg. Levels of metallothioneins, total glutathione, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase were evaluated at 3 and 6 days post-injection. Tin load was measured in the muscle of the same fish. Differences were observed in the time-course accumulation of tin with a clear dose-response relationship. Although individual oxidative stress biomarkers varied, the biomarker profile indicated different stress mechanisms caused by both TBTC and TBTE. The weak induction of metal-trapping metallothioneins and the changes of oxidative stress biomarkers suggested a stress-pressure in both TBT-treated trout, advising for an ecotoxicological risk for freshwater ecosystems.

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Lipid accumulation, oxidative stress and immune-related molecules affected by tributyltin exposure in muscle tissues of rare minnow ( Gobiocypris rarus )

Cited by 20 publications

References 66 publications

Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps

Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps

Skeletal Muscle Lipidomics as a New Tool to Determine Altered Lipid Homeostasis in Fish Exposed to Urban and Industrial Wastewaters

Metal load and oxidative stress driven by organotin compounds on rainbow trout

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