Lipid and apoprotein modifications in body builders during and after self-administration of anabolic steroids

Baldo-Enzi, Goretta; Giada, Franco; Zuliani, Giovanni; Baroni, Luciana; Vitale, E.; Enzi, Giuliano; Magnanini, Patrizia; Fellin, Renato

doi:10.1016/0026-0495(90)90076-o

Cited by 46 publications

(12 citation statements)

References 25 publications

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“…The depressed apolipoprotein Al and Al /B values confirm data reported in previous studies (Baldo-Enzi et al, 1990;Cohen, Faber, Benade, & Noakes, 1986;Lenders et al, 1988). Baldo-Enzi & Stolley (1977) reported depressed Al/B levels in a group of weight trainers who had taken anabolic steroids for at least 2 months as compared to a similar group of nonusers.…”

Section: Roes: March 1997supporting

confidence: 89%

Serum Lipoprotein Patterns in Long-Term Anabolic Steroid Users

Sachtleben

Berg²,

Cheatham³

et al. 1997

Research Quarterly for Exercise and Sport

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Section: Roes: March 1997supporting

confidence: 89%

Serum Lipoprotein Patterns in Long-Term Anabolic Steroid Users

Sachtleben

Berg²,

Cheatham³

et al. 1997

Research Quarterly for Exercise and Sport

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“…Several studies suggest that AAS abuse in athletes increase low-density lipoprotein (LDL) levels by >20% 14,36–38 and decrease high-density lipoprotein (HDL) levels by 20% to 70%. 13,14,37,39–44 More generally, steroid hormones alter serum lipoprotein levels via the lipolytic degradation of lipoproteins and their removal by receptors through modification of apolipoprotein A-I and B synthesis. Although some studies have shown an association between AAS and elevated LDL, no definitive mechanism has been established.…”

Section: Resultsmentioning

confidence: 99%

Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm

Achar

Rostamian

Narayan

2010

The American Journal of Cardiology

231

180

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Recent surveys and reports suggest that many athletes and bodybuilders abuse anabolic-androgenic steroids (AAS). However, scientific data on the cardiac and metabolic complications of AAS abuse are divergent and often conflicting. A total of 49 studies describing 1,467 athletes were reviewed to investigate the cardiovascular effects of the abuse of AAS. Although studies were typically small and retrospective, some associated AAS abuse with unfavorable effects. Otherwise healthy young athletes abusing AAS may show elevated levels of low-density lipoprotein and low levels of high-density lipoprotein. Although data are conflicting, AAS have also been linked with elevated systolic and diastolic blood pressure and with left ventricular hypertrophy that may persist after AAS cessation. Finally, in small case studies, AAS abuse has been linked with acute myocardial infarction and fatal ventricular arrhythmias. In conclusion, recognition of these adverse effects may improve the education of athletes and increase vigilance when evaluating young athletes with cardiovascular abnormalities.

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“…Nontherapeutic AAS use has been related to increased serum levels of hepatic enzymes (Schwingel et al, 2011) and low-density lipoprotein (LDL-C) (Baldo-Enzi et al, 1990;Evans, 2004), along with decreased levels of highdensity lipoprotein (HDL-C) (Baldo-Enzi et al, 1990;Schwingel et al, 2011). Similar changes have been observed in subjects who smoke over 10 cigarettes per day or engage in heavy alcohol 1 intake (Whitehead, Robinson, & Allaway, 1996).…”

Section: Introductionmentioning

confidence: 79%

“…AAS use alone leads to a Data are presented as mean ± SD, or number of subjects (%). -Enzi et al, 1990;Hartgens, Rietjens, Keizer, Kuipers, Wolffenbuttel, 2004;Schwingel et al, 2011). Furthermore, lipid-lipoprotein imbalance has been demonstrated to be dose dependent and influenced by time of use as well (McGrath, McRobb, & Heather, 2008).…”

Section: Discussionmentioning

confidence: 96%

The Influence of Concomitant Use of Alcohol, Tobacco, Cocaine, and Anabolic Steroids on Lipid Profiles of Brazilian Recreational Bodybuilders

Schwingel¹,

Zoppi

Cotrim

2014

Substance Use & Misuse

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Anabolic-androgenic steroids (AAS) are used to enhance physical performance and/or appearance. The aim of this study was to evaluate the influence of the concomitant use of alcohol, tobacco, cocaine, and AAS on blood lipid profiles of 145 asymptomatic male bodybuilders from the Northeast region of Brazil. Interviews, clinical exams, and serological evaluations were performed on all participants between 2007 and 2009. All subjects' self-reported use of testosterone or its derivatives, 118 individuals reported alcohol intake, 27-reported cigarette smoking, and 33 confirmed cocaine use. Four subjects were users of all drugs at the same time. Higher levels of total cholesterol and LDL-cholesterol were observed among concomitant users of alcohol, tobacco, cocaine, and AAS. The study's limitations are noted.

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Lipid and apoprotein modifications in body builders during and after self-administration of anabolic steroids

Cited by 46 publications

References 25 publications

Serum Lipoprotein Patterns in Long-Term Anabolic Steroid Users

Serum Lipoprotein Patterns in Long-Term Anabolic Steroid Users

Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm

The Influence of Concomitant Use of Alcohol, Tobacco, Cocaine, and Anabolic Steroids on Lipid Profiles of Brazilian Recreational Bodybuilders

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