Lipid-based carriers for food ingredients delivery

Barroso, Lívia Alves; Viegas, Cláudia Marina; Vieira, João; Ferreira-Pêgo, Cíntia; Costa, Joyce Maria Gomes da; Fonte, Pedro

doi:10.1016/j.jfoodeng.2020.110451

Cited by 58 publications

(28 citation statements)

References 132 publications

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“…This technology offers a broad scope of applications in business sectors as varied as pharmaceuticals, cosmetics, agrochemicals and food industries. Probiotics, antioxidants, minerals, flavoring agents, sweeteners, and nutrients are among the ingredients that have already been encapsulated for food applications [1,2]. In this case, encapsulation has been developed to protect the ingredient from moisture, heat, or other extreme conditions, as well as to impede its interactions with the food matrix and to improve the food organoleptic properties (odor, taste, etc.).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of ε-Viniferin into Multi-Lamellar Liposomes: Development of a Rapid, Easy and Cost-Efficient Separation Method to Determine the Encapsulation Efficiency

et al. 2021

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Onion-type multi-lamellar liposomes (MLLs), composed of a mixture of phosphatidylcholine and Tween 80, were analyzed for their ability to encapsulate ε-Viniferin (εVin), a resveratrol dimer. Their encapsulation efficiency (EE) was measured by UV-VIS spectroscopy using three different separation methods—ultracentrifugation, size exclusion chromatography, and a more original and advantageous one, based on adsorption filtration. The adsorption filtration method consists indeed of using syringe filters to retain the molecule of interest, and not the liposomes as usually performed. The process is rapid (less than 10 min), easy to handle, and inexpensive in terms of sample amount (around 2 mg of liposomes) and equipment (one syringe filter is required). Whatever the separation method, a similar EE value was determined, validating the proposed method. A total of 80% ± 4% of εVin was found to be encapsulated leading to a 6.1% payload, roughly twice those reported for resveratrol-loaded liposomes. Finally, the release kinetics of εVin from MLLs was followed for a 77 day period, demonstrating a slow release of the polyphenol.

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Section: Introductionmentioning

confidence: 99%

Encapsulation of ε-Viniferin into Multi-Lamellar Liposomes: Development of a Rapid, Easy and Cost-Efficient Separation Method to Determine the Encapsulation Efficiency

et al. 2021

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“…Lipid-based delivery systems (LBDSs) involve delivery systems which are principally composed of physiological lipid analogs such as surfactants as stabilizers ( Figure 3A,B). LBDSs have been recognized for their promising biocompatibility, competency in GIT penetration, easy to scale-up and broad application [102,274]. LBDSs have been admired for their potential for drug delivery through various administration routes, particularly for the oral delivery of lipophilic drugs, because of their competence to mimic the food lipids during the digestive process [275,276].…”

Section: Lipid-based Delivery Systemsmentioning

confidence: 99%

“…With their properties, lipid-based delivery systems offer an array of advantages over polymer-based systems as shown in Table 2. Some of these advantages of lipid-based nanodelivery systems entail: (i) biocompatibility and use of nontoxic excipients [274,277]; (ii) high drug payload [143]; (iii) viability of incorporating both lipophilic and hydrophilic bioactives [274]; (iv) prospect of controlled release and drug targeting; (v) improved drug stability [278]; (vi) averting of organic solvents [279]; (vii) cost-effectiveness [280]; (viii) ease of scale-up during production and sterilization [95]. Over the course of time, a range of lipid-based delivery systems have been developed for encapsulating bioactive compounds such as micelles, micro-and nanoemulsions, liposomes, niosomes, solid lipid carriers, nanostructured lipid carriers, bilosomes, cubosomes, etc.…”

Section: Lipid-based Delivery Systemsmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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“…Lipid-based delivery systems (LBDSs) involve those delivery systems which are principally composed of physiological lipid analogs such as surfactants as stabilizers (Figure 1A and B). LBDSs have been recognized for their promising biocompatibility, competency in GIT penetration, easy to scale-up and broad application [102,170]. LBDS have been admired for their potential for drug delivery through various administration routes, particularly for the oral delivery of lipophilic drugs, because of their competence to mimic the food lipids during the digestive process [171,172].…”

Section: Lipid Based Delivery Systemsmentioning

confidence: 99%

“…With their properties, lipid-based delivery systems offer an array of advantages over polymer-based systems as shown in Table 2. Some of these advantages of lipid based nanodelivery systems entail (i) biocompatibility and use of nontoxic excipients [170,173]; (ii) high drug payload [174]; (iii) viability of incorporating both lipophilic and hydrophilic bioactives [170]; (iv) prospect of controlled release and drug targeting; (v) improved drug stability [175]; (vi) averting of organic solvents [176]; (vii) cost effectiveness [177]; as well as (viii) ease of scale-up during production and sterilization [95]. During the course of time, a range of lipid-based delivery systems have been developed for encapsulating bioactive compounds such as micelles, micro and nanoemulsions, liposomes, niosomes, solid lipid carriers, nanostructured lipid carriers, bilosomes, cubosomes etc.…”

Section: Lipid Based Delivery Systemsmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya¹,

Shakya²,

Aggarwal³

et al. 2021

Preprint

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Accruing evidence on the influence of β-carotene regarding the prevention of several chronic diseases - in addition to its well-acknowledged role in vision has been a strong driver for developing alternative delivery systems. Though oral delivery is accepted as the most fitting, mild and safe path for delivering bioactive agents, β-carotene delivery via food items poses challenges due to its lipophilic nature, poor water-solubility, high chemical/photochemical instability and poor oral bioavailability. Nanotechnology has opened new windows for delivering bioactive agents. Their physiochemical characteristics, i.e. small size, high surface area, unique composition, biocompatibility and biodegradability make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers inherit some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has been rapidly evolved, with a plethora of innovative nano-engineered materials, including micelles, nano/microemulsion, liposomes, niosomes, solid-lipid nanoparticles and nanostructured lipid carriers. These nano-delivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nano-delivery systems adopted for developing functional foods: depicting their classification, composition, preparation methods, challenges, release-and absorption of β-carotene in the GIT and possible risks and future prospects.

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Lipid-based carriers for food ingredients delivery

Cited by 58 publications

References 132 publications

Encapsulation of ε-Viniferin into Multi-Lamellar Liposomes: Development of a Rapid, Easy and Cost-Efficient Separation Method to Determine the Encapsulation Efficiency

Encapsulation of ε-Viniferin into Multi-Lamellar Liposomes: Development of a Rapid, Easy and Cost-Efficient Separation Method to Determine the Encapsulation Efficiency

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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