Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study

Koehl, Niklas J.; Shah, Sanket M.; Tenekam, Ingrid Djouka; Khamiakova, Tatsiana; Sauwen, Nicolas; Vingerhoets, Sien; Coppenolle, Hans; Holm, René

doi:10.1007/s11095-021-03088-8

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Lipid-based drug delivery systems such as self-microemulsifying drug delivery systems (SMEEDS) and self-nanoemulsifying drug delivery systems (SNEEDS) have attracted attention in pharmaceutical science in improving the oral bioavailability of drugs. , Prodrug 9 possessed a high c log P (8.11) and is a good candidate for evaluating the enhancement of prodrug absorption and parent drug bioavailability by lipid-based formulation. Consequently, several off-the-shelf lipid-based formulations were prepared as dosing vehicles for prodrug 9 for PK studies in mice (Table S6).…”

Section: Resultsmentioning

confidence: 99%

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Li²,

Kong³

et al. 2023

ACS Omega

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Effective oral therapies are urgently required to treat KRASG12D mutant cancers. Therefore, synthesis and screening were performed for 38 prodrugs of MRTX1133 to identify an oral prodrug of MRTX1133, a KRASG12D mutant protein-specific inhibitor. In vitro and in vivo evaluations revealed prodrug 9 as the first orally available KRASG12D inhibitor. Prodrug 9 exhibited improved pharmacokinetic properties for the parent compound in mice and was efficacious in a KRASG12D mutant xenograft mouse tumor model after oral administration.

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Section: Resultsmentioning

confidence: 99%

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Li²,

Kong³

et al. 2023

ACS Omega

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“…Preparation of Liquid Formulation F14 to be filled in Hard Gelatin Capsule 13,16,39,42 : Method: To a container PEG 400 (10%), propylene glycol (10%) and water (3%) were added under stirring and heating. The product temperature was maintained at 90°C.…”

Section: Preparation Of Liquid Filled Hard Gelatin Capsulementioning

confidence: 99%

“…Then we use our samples for analysis to measure the turbidity and the turbidity of our sample/s is measured as shown on nephelometer in NTU. 16 Correlations: The coefficient of correlation (r) was calculated with the help of computer-aided preprogrammed software. The 't' values fo 't-test of significance were also calculated.…”

Section: In-vitro Release Studymentioning

confidence: 99%

Untitled

2023

IJPSR

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Background Diclofenac Potassium is the potassium salt form of diclofenac, a benzene acetic acid derivate, and nonsteroidal antiinflammatory drug (NSAID) with analgesic, antipyretic and antiinflammatory activity. Aim: Therefore, the purpose of the present study was to formulate and evaluate liquid-filled hard gelatin capsules of diclofenac potassium. Methods: The liquid-filled soft gelatin capsules were prepared by using PEG 400, propylene glycol and water mixture under temp of 90 0 C followed by adding PVA, Cremophore EL, Labrasol and in last diclofenac potassium was finally added to the mixture under stirring. The final formulation was filled in a hard gelatin capsule, and the hand band seal was performed. Physico-Chemical Evaluation: A total fifteen liquid-filled hard gelatin capsule formulations were prepared (F-1 to F-15) and evaluated for weight variation test, lock length, drug content, nephelometric turbidity units (NTU) and in-vitro release study. Results: The drug content ranged from 92.76±0.12 to 99.25 ±0.19. The results indicated that the drug content was uniform in all the formulations. The disintegration time ranges from 130 sec to 232 sec. In-vitro dissolution study shows % cumulative drug release ranging from 84.10±1.76 to 99.57±0.653. Optimized formulation F14 at 40± 2⁰C, 75 ± 5% RH was found to be stable up to 30 days. Conclusion: Hence liquid filled hard gelatin capsule of diclofenac potassium can be a potential alternative to available traditional oral drug delivery systems of diclofenac potassium to improve its bioavailability.

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“…These groups provide various characteristics, including flexibility, hydration, gelation temperature, and LCST behavior. Moreover, in medical engineering, HPMC is mainly used as a material for encapsulating drugs [ 88 ] or as an ink tackifier in TE scaffolds [ 89 ] . Götz et al .…”

Section: Cellulose Derivatives For 3d Printingmentioning

confidence: 99%

Application of 3D-bioprinted nanocellulose and cellulose derivative-based bio-inks in bone and cartilage tissue engineering

Liu¹,

Jiang²,

Yang³

et al. 2022

IJB

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Three-dimensional (3D) printing is a modern, computer-aided, design-based technology that allows the layer-by-layer deposition of 3D structures. Bioprinting, a 3D printing technology, has attracted increasing attention because of its capacity to produce scaffolds for living cells with extreme precision. Along with the rapid development of 3D bioprinting technology, the innovation of bio-inks, which is recognized as the most challenging aspect of this technology, has demonstrated tremendous promise for tissue engineering and regenerative medicine. Cellulose is the most abundant polymer in nature. Various forms of cellulose, nanocellulose, and cellulose derivatives, including cellulose ethers and cellulose esters, are common bioprintable materials used to develop bio-inks in recent years, owing to their biocompatibility, biodegradability, low cost, and printability. Although various cellulose-based bio-inks have been investigated, the potential applications of nanocellulose and cellulose derivative-based bio-inks have not been fully explored. This review focuses on the physicochemical properties of nanocellulose and cellulose derivatives as well as the recent advances in bio-ink design for 3D bioprinting of bone and cartilage. In addition, the current advantages and disadvantages of these bioinks and their prospects in 3D printing-based tissue engineering are comprehensively discussed. We hope to offer helpful information for the logical design of innovative cellulose-based materials for use in this sector in the future.

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Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study

Cited by 7 publications

References 21 publications

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Untitled

Application of 3D-bioprinted nanocellulose and cellulose derivative-based bio-inks in bone and cartilage tissue engineering

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Lipid Based Formulations in Hard Gelatin and HPMC Capsules: a Physical Compatibility Study

Cited by 7 publications

References 21 publications

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRASG12D Mutation

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRASG12D Mutation

Untitled

Application of 3D-bioprinted nanocellulose and cellulose derivative-based bio-inks in bone and cartilage tissue engineering

Contact Info

Product

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Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation