Lipid-based nanoparticles for photosensitive drug delivery systems

Abstract

Background Numerous drug delivery strategies have been studied, but many hurdles exist in drug delivery rates to the target site. Recently, researchers have attempted to remotely control the in vivo behavior of drugs with light to overcome the shortcomings of conventional drug delivery systems. Photodynamic and photothermal systems are representative strategies wherein a photosensitive material is activated in response to a specific wavelength of light. Area covered Photosensitive materials generally exhibit poor solubility and low biocompatibility. Additionally, their low photostability negatively affects delivery performance. A formulation of lipid-based nanoparticles containing photosensitive substances can help achieve photosensitive drug delivery with improved biocompatibility. The lipid bilayer structure, which can be assembled and disassembled by modulating the surrounding conditions (temperature, pH, etc.), can also be crucial for controlled release of drugs. Expert opinion To the best of our knowledge, translation research on photoresponsive nanoparticles is scarce. However, as various drugs based on lipid nanoparticles have been clinically approved, the development potential of the lipid-based photoresponsive nanoparticles seems high. Thus, the identification of valid indications and development of optimum medical devices will increase the interest in photoresponsive material-based nanoparticles.

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Nanorod/nanodisk‐integrated liquid crystalline systems for starvation, chemodynamic, and photothermal therapy of cancer

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“…Recently, in addition to conventional chemotherapy, various approaches such as chemodynamic therapy (CDT), immunotherapy, photodynamic therapy, photothermal therapy (PTT), and sonotherapy have been attempted with diverse pharmaceutical formulations and drug delivery systems for combating cancers 1–15 . Among these emerging therapeutic techniques, the combination of CDT and phototherapy has been widely investigated for their reactive oxygen species (ROS)‐mediated anticancer mechanisms 16 .…”

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