Lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma

Abstract

Epidemiological data show that there is a close relation of high fat diet and obesity to the raising incidence rate of colorectal tumor [1, 2] . Some studies suggest that high blood lipid is a higher colorectal adenoma and colorectal cancer risk factors [3] , but there are also some studies have reported high cholesterol and the incidence of colorectal adenoma was no correlation [4] . The relationship between dyslipidemia and colorectal adenoma is still no consensus view. A large number of studies have shown that lipid peroxidation is closely related to the occurrence of colorectal cancer. This study explored the plasma lipid levels and lipid peroxidation levels change and the relationship between colorectal adenoma, aimed to further clarify dyslipidemia and plasma lipid peroxidation levels and the relationship between colorectal adenoma. Materials and methods ObjectsA total of 150 individuals, non-related were studied. Cases diagnosed with colonoscopy of 100 patients with colorectal adenomas (all were confirmed with pathologic diagnosis), 52 cases were males, 48 females, average age was (56.6 ± 7.1) years old. The control case for the whole colonoscopy did not find lesions in 50 patients, 26 cases were males and 24 females, average age with (54.1 ± 6.9) years old. The groups were matched by age and gender. The cases that had a history of colon operation, colon malignant tumor, diabetes, hyperlipoidemia and the recent use of drugs that affect blood lipids, non-steroidal anti-inflammatory drugs and contraceptives were rejected. The histological categories of colorectal adenomas were tubular adenoma, tubulovillous adenoma that also was named as mixed adenoma and villous adenoma. All objects were Chinese people. The anus to the splenic flexure of the colon was defined as the distal colon, cecum to the splenic flexure of the colon was defined as the proximal colon. Fifty-one cases were distal colorectal adenomas, 44 cases were proximal colorectal adenomas and 5 cases were distal and proximal colorectal adenomas. The cases having Abstract Objective: The aim of this study was to investigate lipid disorders and lipid peroxidation associated with the malignant transformation of colorectal adenoma. Methods: Analyses were based on data from 100 subjects with histologically confirmed adenomas (cases) and 50 adenoma-free control subjects, all of whom had colonoscopy. The subjects were divided into two groups: those with no adenoma and those with adenoma. According to subsite of adenomas the subjects with adenoma were divided into group of distal adenoma and group of proximal adenoma. According to histology of adenomas the subjects with adenoma were divided into group of villiform adenoma and group of tubular + tubulo-villous adenoma. Among the groups, the serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and lipid peroxidation product malondialdehyde (MDA) were compared in all the patients. Results: Plasma total cholesterol...

Potential effects of miR‑146 expression in relation to malondialdehyde as a biomarker for oxidative damage in patients with breast cancer

“…For a more in-depth understanding of oxidative stress, the present study measured the MDA levels in patients with breast cancer and compare these to those of healthy women. Increased levels of MDA have been reported in breast, ovary, gastric and lung cancers, as well as in colorectal adenomas (38)(39)(40)(41)(42)(43). The reaction between polyunsaturated fatty acids and free radicals can produce MDA, a low-molecular-weight aldehyde.…”