2022
DOI: 10.3390/ijms232012584
|View full text |Cite
|
Sign up to set email alerts
|

Lipid Droplets and Their Participation in Zika Virus Infection

Abstract: Lipid droplets (LDs) are highly conserved and dynamic intracellular organelles. Their functions are not limited to serving as neutral lipid reservoirs; they also participate in non-energy storage functions, such as cell lipid metabolism, protection from cell stresses, maintaining protein homeostasis, and regulating nuclear function. During a Zika virus (ZIKV) infection, the viruses hijack the LDs to provide energy and lipid sources for viral replication. The co-localization of ZIKV capsid (C) protein with LDs … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(8 citation statements)
references
References 152 publications
0
8
0
Order By: Relevance
“…Wolbachia- mediated disruption of host cholesterol metabolic processes impacts lipid droplets, which are vital for viral particle assembly, formation, and trafficking to the ER, which has implications for replication complex formation ( 25 ). We determined how Wolbachia alters cholesterol storage by investigating cholesterol esterase activity.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…Wolbachia- mediated disruption of host cholesterol metabolic processes impacts lipid droplets, which are vital for viral particle assembly, formation, and trafficking to the ER, which has implications for replication complex formation ( 25 ). We determined how Wolbachia alters cholesterol storage by investigating cholesterol esterase activity.…”
Section: Discussionmentioning
confidence: 99%
“…This means that in Wolbachia -positive cells, there is no substrate available for cholesterol esterases to work on and, therefore, the expression of cholesterol esterase genes is not upregulated. ZikV is reliant on lipid droplets for the formation of its capsid protein and uses resources from lipid droplets while synthesizing replication complexes ( 25 ). Since lipid droplet depletion in Wolbachia- infected cells decreases sources of cholesterol, ZikV is unable to use these resources to the same extent as in Wolbachia- free cells, therefore decreasing viral replication.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…An increase in LDs has been observed in the early stages of infection, suggesting that these viruses promote LDs biogenesis to facilitate their replication and assembly. However, in the later stages of infection, the amount of LDs decreases, which is attributed to their selective autophagy [ 89 , 90 , 91 ].…”
Section: Role Of Lipid Droplets In the Viral Infection Cycle And Huma...mentioning
confidence: 99%