Lipid-hydrogel films for sustained drug release

Kulkarni, Chandrashekhar V.; Moinuddin, Zeinab; Patil-Sen, Yogita; Littlefield, Rowan; Hood, Mitesh

doi:10.1016/j.ijpharm.2015.01.013

Cited by 30 publications

(29 citation statements)

References 25 publications

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“…Similar efforts were also made by other researchers who managed to stabilize O/W nanostructured emulsions using silica nanoparticles [72] and laponite or montmorillonite clay platelets [80,130,131]. As mentioned earlier, we were also able to construct lipid-hydrogel hybrid systems and demonstrate their potential for loading and release of functional molecules in a sustained manner [128] (Figure 8). These novel nanocomposite systems appear to be highly promising for future cosmetic applications as they could benefit from the special characteristics of both "lipid nanostructures" and the "other component, i.e., CNT, C60, silica nanoparticle, clay platelet or hydrogel".…”

Section: Nano-hybrid Systems Based On Lipid Nanostructuressupporting

confidence: 76%

Section: Modulating Structure and Properties Of Lipid Systemsmentioning

confidence: 99%

“…This mixed system can be subsequently dehydrated to obtain dry films where the lipid particles are fully immobilized [127] (Figure 6). These thermos-reversible hydrogel systems can be rehydrated and re-dispersed on demand, which is highly useful for their storage, transport and potential biotechnological applications [128]. The W/O nanostructured emulsions exist in a range of consistencies including fluid, gel and cream, and also offer a great tunability in terms of their apparent viscosity [68,101].…”

Section: Modulating Structure and Properties Of Lipid Systemsmentioning

confidence: 99%

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Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Kulkarni

2016

Cosmetics

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A majority of cosmetic products that we encounter on daily basis contain lipid constituents in solubilized or insolubilized forms. Due to their amphiphilic nature, the lipid molecules spontaneously self-assemble into a remarkable range of nanostructures when mixed with water. This review illustrates the formation and finely tunable properties of self-assembled lipid nanostructures and their hierarchically organized derivatives, as well as their relevance to the development of cosmetic formulations. These lipid systems can be modulated into various physical forms suitable for topical administration including fluids, gels, creams, pastes and dehydrated films. Moreover, they are capable of encapsulating hydrophilic, hydrophobic as well as amphiphilic active ingredients owing to their special morphological characters. Nano-hybrid materials with more elegant properties can be designed by combining nanostructured lipid systems with other nanomaterials including a hydrogelator, silica nanoparticles, clays and carbon nanomaterials. The smart materials reviewed here may well be the future of innovative cosmetic applications.

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Section: Nano-hybrid Systems Based On Lipid Nanostructuressupporting

confidence: 76%

Section: Modulating Structure and Properties Of Lipid Systemsmentioning

confidence: 99%

Section: Modulating Structure and Properties Of Lipid Systemsmentioning

confidence: 99%

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Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Kulkarni

2016

Cosmetics

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“…In this work, we have prepared oil‐in‐water (o/w) emulsions of butter oil using a tri‐block copolymer ‐ pluronic ® F127, which was not used previously for this purpose. This stabilizer has been quite successful for stabilizing a range of lipid based emulsions (Engelskirchen, Maurer, & Glatter, ; Nakano et al, ; Yaghmur, de Campo, Sagalowicz, Leser, & Glatter, ) and hybrid systems developed from them (Kulkarni and Glatter, ; Kulkarni, Moinuddin, Patil‐Sen, Littlefield, & Hood, ; Kulkarni, TomšIč, & Glatter, ). These systems have already demonstrated their potential as efficient drug carriers for poorly water soluble drugs (Chong, Mulet, Boyd, & Drummond, ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic processing of butter oil (ghee) into oil-in-water emulsions

Kulkarni

2016

Journal of Food Processing and Preservation

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Butter oil (ghee) derived from cow or buffalo milk is in semi-solid form at room temperature and contains >99% of lipids. Apparent high viscosity and water immiscibility -owing to the hydrophobic nature of lipid components hinder the applicability of butter oil for formulations.Here, we have employed ultrasonic processing technique to create oil-in-water emulsions of butter oil. We show that the butter oil is capable of self-stabilizing an emulsion at low concentration while higher concentrations could be kinetically stabilized using pluronic stabilizer. We were able to modulate water contents of emulsions in the range of 80-95% and maintain the particle size in submicron range. Reported butter oil emulsions retain hydrophobic properties of the original butter oil within cores of dispersed particles, overcome a problem of butter oil-water immissibility, display fluid consistency and are stable for several months. These properties are highly suitable for developing food, pharmaceutical and cosmetic formulations.

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“…Furthermore, the effect of nanoformulated CUR incorporated into the hydrogel matrix is of interest. Although drug-loaded polymer micelles incorporated into hydrogel matrices are readily found in the literature 17,28,29,65 , such systematic investigations of the viscoelastic properties of compound materials hydrogels are rare. In addition, to assess the potential as an injectable thermogelling drug depot, the CUR-loaded hydrogels were injected into a collagen matrix and CUR release quantified.…”

Section: Introductionmentioning

confidence: 99%

Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release

Lübtow¹,

Lorson²,

Finger³

et al. 2019

Preprint

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Hydrogel based drug depot formulations are of great interest for therapeutic applications. Here, the impact of incorporated drug, neat polymer micelles, and drug-loaded micelles on the viscoelastic properties of a cytocompatible hydrogel was investigated systematically. To challenge the hydrogel with regard to the desired application as injectable drug depot, curcumin (CUR) was chosen as a model compound due to its very low-water solubility and limited stability. CUR was either directly solubilized by the hydrogel or pre-incorporated into polymer micelles. Drug-release from a collagen matrix was studied in a trans-well setup and extended drug release over 10 weeks.<br>

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Lipid-hydrogel films for sustained drug release

Cited by 30 publications

References 25 publications

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Ultrasonic processing of butter oil (ghee) into oil-in-water emulsions

Combining Ultra-High Drug Loaded Micelles and Shear Thinning, Injectable Hydrogel Drug Depots for Prolonged Drug Release

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