Lipid levels in anorexia nervosa

Mehler, Philip S.; Lezotte, Dennis; Eckel, Robert H.

doi:10.1002/(sici)1098-108x(199809)24:2<217::aid-eat11>3.0.co;2-w

Cited by 32 publications

(27 citation statements)

References 10 publications

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“…The higher concentrations were based on higher LDL-Chol levels, as also described in previous studies (Mordasini et al 1978), but not confirmed by others (Arden et al 1990;Mehler et al 1998). The mean difference between CO and AN in our present study was rather small, in contrast to markedly elevated Chol levels found in reasonably large cohorts in early reports in the literature (Klinefelter, 1965; Crisp et al 1968;Mehler et al 1998;Mordasini et al 1978). A high degree of selection of patients of certain subgroups in these studies could be the reason.…”

Section: Discussionsupporting

confidence: 63%

Lipoprotein metabolism in patients with anorexia nervosa: a case–control study investigating the mechanisms leading to hypercholesterolaemia

et al. 2004

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Hypercholesterolaemia is a common finding in patients with anorexia nervosa (AN). To investigate the type, frequency and pathophysiological mechanisms of changes in lipoprotein metabolism in AN we performed a cross-sectional study in fifty-eight female patients (mean age 24·2 years, BMI 15·3 (SD 1·5) kg/m 2 ) and fifty-eight healthy age-matched controls (CO; BMI 22·2 (SD 1·7) kg/m 2 ). Total cholesterol and LDL-cholesterol were higher in AN (5·5 (SD 1·3) v. 5·0 (SD 0·8) mmol/l, P¼0·023; 3·6 (SD 1·1) v. 3·2 (SD 0·7) mmol/l, P¼0·025 respectively). LDL particles were significantly more enriched in cholesterol and triacylglycerol in AN. In multiple regression analysis with LDL-cholesterol as the dependent and BMI, total body fat ( %), lathosterol:cholesterol ratio (endogenous cholesterol synthesis), 7a-hydroxy-4-cholesten-3-one (bile acid synthesis), non-esterified glycerol, free triiodothyronine and free thyroxine as independent variables, BMI was the only significant predictor in CO (R 2 0·36, overall P¼0·001). In AN the variability of LDL-cholesterol was significantly predicted by total body fat, free thyroxine, BMI, free triiodothyronine and non-esterified glycerol (R 2 0·55, overall P,0·001). Subgroup analysis between restricting (AN-R) and binge-eating -purging patients (AN-B) indicated that in AN-R changes in lipoproteins, BMI and total body fat were more pronounced. AN-R patients had lower bile acid synthesis than AN-B (P¼0·02). We conclude that elevated cholesterol concentrations in AN are generally due to an increase in LDL-cholesterol, which is mostly determined by the severe loss of body fat and the resulting changes in thyroid hormones, increased lipolysis and decreased endogenous cholesterol synthesis with resulting decrease in LDL removal. The clinical subtype of AN plays a major role in the mechanisms leading to hypercholesterolaemia.Anorexia nervosa: Lipoprotein metabolism: Hypercholesterolaemia

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Section: Discussionsupporting

confidence: 63%

Lipoprotein metabolism in patients with anorexia nervosa: a case–control study investigating the mechanisms leading to hypercholesterolaemia

et al. 2004

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“…features [19,20]. The level was normalized by rhGH, indicating that this AN-specific metabolism of HDLcholesterol is partly related to the insufficient action of GH in this syndrome.…”

Section: Discussionmentioning

confidence: 87%

“…It is well documented that hypercholesterolemia is present in patients with AN [19,20]. Administration of rhGH decreased total cholesterol level.…”

Section: Discussionmentioning

confidence: 98%

Administration of Recombinant Human Growth Hormone Normalizes GH-IGF1 Axis and Improves Malnutrition-related Disorders in Patients with Anorexia Nervosa

Hashizume

Suzuki

et al. 2007

Endocr J

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“…However, the serum total cholesterol values in patients with AN in previously published papers were widely distributed (10,11,(17)(18)(19)(20)(21). Although the frequency of cardiac events in patients with BN is not clear, the serum cholesterol values in patients with BN were also widely distributed (22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 93%

“…The implications of the long-term elevation of cholesterol influencing the morbidity in eating disorders must not be neglected. Given the chronicity of this condition, the development of elevated concentrations of cholesterol at an early age may increase the risk of atheroma formation and ischemic heart disease (20,31).…”

Section: Discussionmentioning

confidence: 99%

Serum Lipid Levels in Patients with Eating Disorders

Nakai¹,

Noma

Fukusima

et al. 2016

Intern. Med.

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Objective To evaluate some risk factors for cardiovascular diseases in feeding and eating disorders, the degree of lipid abnormalities was investigated in a large Japanese cohort of different groups of feeding and eating disorders, according to the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012 (JAS Guidelines 2012). Methods Participants in the current study included 732 women divided into four groups of feeding and eating disorders: anorexia nervosa, restricting type (AN-R); anorexia nervosa, binge-eating/purging type; bulimia nervosa (BN); and binge-eating disorder (BED). We measured the serum levels of total cholesterol, highdensity-lipoprotein (HDL) cholesterol, and triglyceride in these participants. Low-density-lipoprotein (LDL) cholesterol and non-HDL cholesterol levels were also calculated. Results The concentrations of LDL cholesterol and non-HDL cholesterol were widely distributed in all groups. When the LDL cholesterol risk was defined as ! 120 mg/dL and the non-HDL cholesterol risk as ! 150 mg/dL, according to the JAS Guidelines 2012, the proportion of LDL cholesterol risk ranged from 29.6% (BN) to 38.6% (AN-R), and the proportion of non-HDL cholesterol risk ranged from 17.8% (BN) to 30.1% (BED). Conclusion The present findings suggest the existence of LDL cholesterol risk and non-HDL cholesterol risk in all groups of eating disorders. Given the chronicity of this condition, the development of elevated concentrations of LDL cholesterol and non-HDL cholesterol at an early age may increase the risk of cardiovascular diseases.

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Lipid levels in anorexia nervosa

Cited by 32 publications

References 10 publications

Lipoprotein metabolism in patients with anorexia nervosa: a case–control study investigating the mechanisms leading to hypercholesterolaemia

Lipoprotein metabolism in patients with anorexia nervosa: a case–control study investigating the mechanisms leading to hypercholesterolaemia

Administration of Recombinant Human Growth Hormone Normalizes GH-IGF1 Axis and Improves Malnutrition-related Disorders in Patients with Anorexia Nervosa

Serum Lipid Levels in Patients with Eating Disorders

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